Evaluation of hypolipidemic effects of Lyciumbarbarum (Goji berry) in a murine model

Preethi G. Pai, Habeeba P. Umma, Sheetal Ullal, P. Ahsan Shoeb, M. S. Pradeepti, Ramya

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Lycium barbarum L. Solanaceae a traditional medicinal plant of China has been accorded a very high safety value. It has been known to possess various benefi cial effects like reducti on of blood glucose and serum lipids in alloxan-induced diabetes models, anti-ageing, immuno-modulating, anti-cancer, anti-fatigue, and male fertility-facilitatory actions. The present study is an attempt to explore the hypolipidemic effects of powdered L. barbarum in high fat diet-induced model of hyperlipidemia. Powdered L. barbarum fruit extract (250mg/kg and 500mg/kg) was administered to Wistar albino rats fed on a cholesterol-rich high-fat diet for 45 days. The effects were compared with the standard drug atorvastatin (10 mg/kg/day, oral). After 30 days of treatment, the lipid profile of the blood samples of the experimental rodents was evaluated. The data presented as mean±SEM were analysed using one-way ANOVA followed by Tukey's post hoc test. P<0.05 was considered as statistically significant. In the present study, L. barbarum powdered extract showed a significant reduction in the total cholesterol, triglycerides and very low density lipoprotein-cholesterol levels at both the doses employed (p<0.05). However, reduction in low density lipoprotein-cholesterol levels was significant (p<0.05) only at the dose of 500 mg/kg when compared to the standard drug group. The increase in high-density lipoprotein levels was significant only at 250 mg/kg. The data thus suggests the positive anti-hyperlipidemic activity of L. barbarum in high fat diet-induced hyperlipidemia in rats.

Original languageEnglish
Pages (from-to)4-8
Number of pages5
JournalJournal of Natural Remedies
Volume13
Issue number1
Publication statusPublished - 01-01-2013

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Lycium
High Fat Diet
Hyperlipidemias
Cholesterol
Solanaceae
Lipids
VLDL Cholesterol
Experimental Diabetes Mellitus
HDL Lipoproteins
Medicinal Plants
Pharmaceutical Preparations
LDL Cholesterol
Fatigue
Fertility
Blood Glucose
Wistar Rats
Rodentia
Fruit
China
Analysis of Variance

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Pai, Preethi G. ; Umma, Habeeba P. ; Ullal, Sheetal ; Ahsan Shoeb, P. ; Pradeepti, M. S. ; Ramya. / Evaluation of hypolipidemic effects of Lyciumbarbarum (Goji berry) in a murine model. In: Journal of Natural Remedies. 2013 ; Vol. 13, No. 1. pp. 4-8.
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Pai, PG, Umma, HP, Ullal, S, Ahsan Shoeb, P, Pradeepti, MS & Ramya 2013, 'Evaluation of hypolipidemic effects of Lyciumbarbarum (Goji berry) in a murine model', Journal of Natural Remedies, vol. 13, no. 1, pp. 4-8.

Evaluation of hypolipidemic effects of Lyciumbarbarum (Goji berry) in a murine model. / Pai, Preethi G.; Umma, Habeeba P.; Ullal, Sheetal; Ahsan Shoeb, P.; Pradeepti, M. S.; Ramya.

In: Journal of Natural Remedies, Vol. 13, No. 1, 01.01.2013, p. 4-8.

Research output: Contribution to journalArticle

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