Evaluation of in vitro antiurolithiatic potential of Bridelia retusa spreng. Bark

Himanshu Trikambhai Makwana, Raviraj Anand Devkar, Manganahalli Manjunath Setty

Research output: Contribution to journalArticle

Abstract

Urolithisis is a very complex disease which is characterized by the formation of renal calculi in urinary track/kidney. Several physic chemical events like super saturation, nucleation, growth, aggregation and retention of dietary minerals of urine in the kidney leads to the formation of kidney stone; for this a essential need to develop a formulation which is made up of medicinal pant belong to the class of Pasanabheda plant according to ancient literature available in Ayurveda, which facilitate the repair mechanism in a natural way towards the organ. Bridelia retusa, is a well know plant of Western Ghats. Present study deals with the inhibitory effect of different fraction of methanol extract of Bridelia retusa. Nucleation of calcium oxalate crystals was estimated by the spectrophotometric assay and whereas crystal dissolution was determine by titrimetry/egg shell permeation method, hence the extract fractions exhibited inhibitory action in both of nucleation and aggregation assays to significant level.

Original languageEnglish
Pages (from-to)1789-1791
Number of pages3
JournalAdvanced Science Letters
Volume23
Issue number3
DOIs
Publication statusPublished - 01-03-2017

All Science Journal Classification (ASJC) codes

  • Health(social science)
  • Computer Science(all)
  • Education
  • Mathematics(all)
  • Environmental Science(all)
  • Engineering(all)
  • Energy(all)

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