Evaluation of methyl cellulose as controlled release matrix material.

K. S. Aithal, A. R. Aroor, Y. V. Pathak, J. Uchil

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Abstract

The formulation for the controlled release of NaF from matrix tablets using Methyl cellulose to prepare chewable NaF tablets for the prevention of dental caries is developed. Various micromeritic studies of granules and tablets containing different concentrations of matrix were studied. Dissolution studies were also carried out in distilled water at 37 +/- 1 degrees C. Significant variations in granule and tablet characteristics were observed depending upon the concentration of the Methyl cellulose used observed. The in vitro drug release reveals that, T 80% values for 30% concentration of matrix is greatest, which seems to be ideal concentration. The drug dissolution is diffusion controlled and follows the Higuchi equation. The fraction of the drug release is proportional to time 1/2 Clinical study is in progress and is encouraging.

Original languageEnglish
Pages (from-to)174-181
Number of pages8
JournalIndian journal of dental research : official publication of Indian Society for Dental Research
Volume2
Issue number2-3
Publication statusPublished - 01-04-1990

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All Science Journal Classification (ASJC) codes

  • Dentistry(all)

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