Evaluation of methyl cellulose as controlled release matrix material.

K. S. Aithal, A. R. Aroor, Y. V. Pathak, J. Uchil

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The formulation for the controlled release of NaF from matrix tablets using Methyl cellulose to prepare chewable NaF tablets for the prevention of dental caries is developed. Various micromeritic studies of granules and tablets containing different concentrations of matrix were studied. Dissolution studies were also carried out in distilled water at 37 +/- 1 degrees C. Significant variations in granule and tablet characteristics were observed depending upon the concentration of the Methyl cellulose used observed. The in vitro drug release reveals that, T 80% values for 30% concentration of matrix is greatest, which seems to be ideal concentration. The drug dissolution is diffusion controlled and follows the Higuchi equation. The fraction of the drug release is proportional to time 1/2 Clinical study is in progress and is encouraging.

Original languageEnglish
Pages (from-to)174-181
Number of pages8
JournalIndian journal of dental research : official publication of Indian Society for Dental Research
Volume2
Issue number2-3
Publication statusPublished - 01-04-1990

Fingerprint

Methylcellulose
Tablets
Dental Caries
Water
Drug Liberation

All Science Journal Classification (ASJC) codes

  • Dentistry(all)

Cite this

@article{c68108bdc2cd488196ba18a24a7c7706,
title = "Evaluation of methyl cellulose as controlled release matrix material.",
abstract = "The formulation for the controlled release of NaF from matrix tablets using Methyl cellulose to prepare chewable NaF tablets for the prevention of dental caries is developed. Various micromeritic studies of granules and tablets containing different concentrations of matrix were studied. Dissolution studies were also carried out in distilled water at 37 +/- 1 degrees C. Significant variations in granule and tablet characteristics were observed depending upon the concentration of the Methyl cellulose used observed. The in vitro drug release reveals that, T 80{\%} values for 30{\%} concentration of matrix is greatest, which seems to be ideal concentration. The drug dissolution is diffusion controlled and follows the Higuchi equation. The fraction of the drug release is proportional to time 1/2 Clinical study is in progress and is encouraging.",
author = "Aithal, {K. S.} and Aroor, {A. R.} and Pathak, {Y. V.} and J. Uchil",
year = "1990",
month = "4",
day = "1",
language = "English",
volume = "2",
pages = "174--181",
journal = "Indian Journal of Dental Research",
issn = "0970-9290",
publisher = "Medknow Publications and Media Pvt. Ltd",
number = "2-3",

}

Evaluation of methyl cellulose as controlled release matrix material. / Aithal, K. S.; Aroor, A. R.; Pathak, Y. V.; Uchil, J.

In: Indian journal of dental research : official publication of Indian Society for Dental Research, Vol. 2, No. 2-3, 01.04.1990, p. 174-181.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Evaluation of methyl cellulose as controlled release matrix material.

AU - Aithal, K. S.

AU - Aroor, A. R.

AU - Pathak, Y. V.

AU - Uchil, J.

PY - 1990/4/1

Y1 - 1990/4/1

N2 - The formulation for the controlled release of NaF from matrix tablets using Methyl cellulose to prepare chewable NaF tablets for the prevention of dental caries is developed. Various micromeritic studies of granules and tablets containing different concentrations of matrix were studied. Dissolution studies were also carried out in distilled water at 37 +/- 1 degrees C. Significant variations in granule and tablet characteristics were observed depending upon the concentration of the Methyl cellulose used observed. The in vitro drug release reveals that, T 80% values for 30% concentration of matrix is greatest, which seems to be ideal concentration. The drug dissolution is diffusion controlled and follows the Higuchi equation. The fraction of the drug release is proportional to time 1/2 Clinical study is in progress and is encouraging.

AB - The formulation for the controlled release of NaF from matrix tablets using Methyl cellulose to prepare chewable NaF tablets for the prevention of dental caries is developed. Various micromeritic studies of granules and tablets containing different concentrations of matrix were studied. Dissolution studies were also carried out in distilled water at 37 +/- 1 degrees C. Significant variations in granule and tablet characteristics were observed depending upon the concentration of the Methyl cellulose used observed. The in vitro drug release reveals that, T 80% values for 30% concentration of matrix is greatest, which seems to be ideal concentration. The drug dissolution is diffusion controlled and follows the Higuchi equation. The fraction of the drug release is proportional to time 1/2 Clinical study is in progress and is encouraging.

UR - http://www.scopus.com/inward/record.url?scp=0025415494&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025415494&partnerID=8YFLogxK

M3 - Article

VL - 2

SP - 174

EP - 181

JO - Indian Journal of Dental Research

JF - Indian Journal of Dental Research

SN - 0970-9290

IS - 2-3

ER -