Evaluation of micronuclei frequency in the cultured peripheral blood lymphocytes of cancer patients before and after radiation treatment

Ganesh Chandra Jagetia, Amrita Jayakrishnan, Donald Fernandes, M. S. Vidyasagar

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

The frequency of micronucleated binucleate lymphocyte (MNBNC) was determined in the peripheral blood lymphocytes of patients suffering from various types of cancer before the onset of radiation treatment, middle (mid-) of the treatment and after completion of the treatment (post-treatment). The frequency of micronuclei increased significantly in the pretreatment sample of cancer patients when compared with the normal untreated healthy volunteers. During the middle of the radiotherapy an approximate two or >two-fold increase was observed in the micronuclei frequency in most of the patients when compared with the concurrent pretreatment samples. Immediately after the completion of treatment, the frequency of micronuclei further increased, and this increase was significantly higher than that of pretreatment and mid-treatment samples. Out of 27 patients analyzed, only nine patients did not have any history of smoking, tobacco chewing or alcohol consumption, while the remaining 18 patients had a history of either smoking, tobacco chewing or alcohol consumption or combination of two or all habits at the time of blood collection.

Original languageEnglish
Pages (from-to)9-16
Number of pages8
JournalMutation Research - Genetic Toxicology and Environmental Mutagenesis
Volume491
Issue number1-2
DOIs
Publication statusPublished - 05-04-2001

Fingerprint

Tobacco Use
Lymphocytes
Radiation
Neoplasms
Alcohol Drinking
Therapeutics
Smoking
Habits
Healthy Volunteers
Radiotherapy

All Science Journal Classification (ASJC) codes

  • Genetics
  • Health, Toxicology and Mutagenesis

Cite this

@article{14dfb6f733b54ba688636d98dc5cb02e,
title = "Evaluation of micronuclei frequency in the cultured peripheral blood lymphocytes of cancer patients before and after radiation treatment",
abstract = "The frequency of micronucleated binucleate lymphocyte (MNBNC) was determined in the peripheral blood lymphocytes of patients suffering from various types of cancer before the onset of radiation treatment, middle (mid-) of the treatment and after completion of the treatment (post-treatment). The frequency of micronuclei increased significantly in the pretreatment sample of cancer patients when compared with the normal untreated healthy volunteers. During the middle of the radiotherapy an approximate two or >two-fold increase was observed in the micronuclei frequency in most of the patients when compared with the concurrent pretreatment samples. Immediately after the completion of treatment, the frequency of micronuclei further increased, and this increase was significantly higher than that of pretreatment and mid-treatment samples. Out of 27 patients analyzed, only nine patients did not have any history of smoking, tobacco chewing or alcohol consumption, while the remaining 18 patients had a history of either smoking, tobacco chewing or alcohol consumption or combination of two or all habits at the time of blood collection.",
author = "Jagetia, {Ganesh Chandra} and Amrita Jayakrishnan and Donald Fernandes and Vidyasagar, {M. S.}",
year = "2001",
month = "4",
day = "5",
doi = "10.1016/S1383-5718(00)00132-7",
language = "English",
volume = "491",
pages = "9--16",
journal = "Mutation Research - Genetic Toxicology and Environmental Mutagenesis",
issn = "1383-5718",
publisher = "Elsevier",
number = "1-2",

}

Evaluation of micronuclei frequency in the cultured peripheral blood lymphocytes of cancer patients before and after radiation treatment. / Jagetia, Ganesh Chandra; Jayakrishnan, Amrita; Fernandes, Donald; Vidyasagar, M. S.

In: Mutation Research - Genetic Toxicology and Environmental Mutagenesis, Vol. 491, No. 1-2, 05.04.2001, p. 9-16.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Evaluation of micronuclei frequency in the cultured peripheral blood lymphocytes of cancer patients before and after radiation treatment

AU - Jagetia, Ganesh Chandra

AU - Jayakrishnan, Amrita

AU - Fernandes, Donald

AU - Vidyasagar, M. S.

PY - 2001/4/5

Y1 - 2001/4/5

N2 - The frequency of micronucleated binucleate lymphocyte (MNBNC) was determined in the peripheral blood lymphocytes of patients suffering from various types of cancer before the onset of radiation treatment, middle (mid-) of the treatment and after completion of the treatment (post-treatment). The frequency of micronuclei increased significantly in the pretreatment sample of cancer patients when compared with the normal untreated healthy volunteers. During the middle of the radiotherapy an approximate two or >two-fold increase was observed in the micronuclei frequency in most of the patients when compared with the concurrent pretreatment samples. Immediately after the completion of treatment, the frequency of micronuclei further increased, and this increase was significantly higher than that of pretreatment and mid-treatment samples. Out of 27 patients analyzed, only nine patients did not have any history of smoking, tobacco chewing or alcohol consumption, while the remaining 18 patients had a history of either smoking, tobacco chewing or alcohol consumption or combination of two or all habits at the time of blood collection.

AB - The frequency of micronucleated binucleate lymphocyte (MNBNC) was determined in the peripheral blood lymphocytes of patients suffering from various types of cancer before the onset of radiation treatment, middle (mid-) of the treatment and after completion of the treatment (post-treatment). The frequency of micronuclei increased significantly in the pretreatment sample of cancer patients when compared with the normal untreated healthy volunteers. During the middle of the radiotherapy an approximate two or >two-fold increase was observed in the micronuclei frequency in most of the patients when compared with the concurrent pretreatment samples. Immediately after the completion of treatment, the frequency of micronuclei further increased, and this increase was significantly higher than that of pretreatment and mid-treatment samples. Out of 27 patients analyzed, only nine patients did not have any history of smoking, tobacco chewing or alcohol consumption, while the remaining 18 patients had a history of either smoking, tobacco chewing or alcohol consumption or combination of two or all habits at the time of blood collection.

UR - http://www.scopus.com/inward/record.url?scp=0035810305&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035810305&partnerID=8YFLogxK

U2 - 10.1016/S1383-5718(00)00132-7

DO - 10.1016/S1383-5718(00)00132-7

M3 - Article

VL - 491

SP - 9

EP - 16

JO - Mutation Research - Genetic Toxicology and Environmental Mutagenesis

JF - Mutation Research - Genetic Toxicology and Environmental Mutagenesis

SN - 1383-5718

IS - 1-2

ER -