Evaluation of oxidative stress, antioxidants and prolactin in infertile women

Veena Bhaskar S, Sharmila Upadhya, Satish Kumar Adiga, Pratap Kumar N

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The objective of the study was to estimate the serum concentrations of oxidative stress markers- lipid hydroperoxide (MDA-Malondialdehyde), lactate dehydrogenase (LDH), nitrite; and ferric reducing antioxidant power (FRAP) - a measure of total antioxidant capacity in serum. Serum nitrite levels were high in fertile women than in infertile women (p<0.001), whereas MDA was high in infertile women than in fertile group (p<0.018). On classifying the entire group of women with infertility based on the etiology, serum MDA and LDH levels were higher in women with infertility due to unexplained factor than in women with other causes contributing to infertility compared to controls (p<0.001, p<0.02). A positive correlation among serum prolactin and nitrite suggested that hyperprolactinemia could contribute to infertility by inducing oxidative damage. Serum FRAP levels showed no significant difference in the groups studied. Lipid peroxidation was high in women with unexplained infertility which may be due to hyperprolactinemia.

Original languageEnglish
Pages (from-to)186-190
Number of pages5
JournalIndian Journal of Clinical Biochemistry
Volume23
Issue number2
DOIs
Publication statusPublished - 2008

Fingerprint

Oxidative stress
Nitrites
Prolactin
Oxidative Stress
Antioxidants
Infertility
L-Lactate Dehydrogenase
Serum
Lipid Peroxides
Hyperprolactinemia
Malondialdehyde
Lipids
Lipid Peroxidation

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

Bhaskar S, Veena ; Upadhya, Sharmila ; Adiga, Satish Kumar ; Kumar N, Pratap. / Evaluation of oxidative stress, antioxidants and prolactin in infertile women. In: Indian Journal of Clinical Biochemistry. 2008 ; Vol. 23, No. 2. pp. 186-190.
@article{4fad84b38a9f47a3b763f608b5f1e734,
title = "Evaluation of oxidative stress, antioxidants and prolactin in infertile women",
abstract = "The objective of the study was to estimate the serum concentrations of oxidative stress markers- lipid hydroperoxide (MDA-Malondialdehyde), lactate dehydrogenase (LDH), nitrite; and ferric reducing antioxidant power (FRAP) - a measure of total antioxidant capacity in serum. Serum nitrite levels were high in fertile women than in infertile women (p<0.001), whereas MDA was high in infertile women than in fertile group (p<0.018). On classifying the entire group of women with infertility based on the etiology, serum MDA and LDH levels were higher in women with infertility due to unexplained factor than in women with other causes contributing to infertility compared to controls (p<0.001, p<0.02). A positive correlation among serum prolactin and nitrite suggested that hyperprolactinemia could contribute to infertility by inducing oxidative damage. Serum FRAP levels showed no significant difference in the groups studied. Lipid peroxidation was high in women with unexplained infertility which may be due to hyperprolactinemia.",
author = "{Bhaskar S}, Veena and Sharmila Upadhya and Adiga, {Satish Kumar} and {Kumar N}, Pratap",
year = "2008",
doi = "10.1007/s12291-008-0041-3",
language = "English",
volume = "23",
pages = "186--190",
journal = "Indian Journal of Clinical Biochemistry",
issn = "0970-1915",
publisher = "Springer India",
number = "2",

}

Evaluation of oxidative stress, antioxidants and prolactin in infertile women. / Bhaskar S, Veena; Upadhya, Sharmila; Adiga, Satish Kumar; Kumar N, Pratap.

In: Indian Journal of Clinical Biochemistry, Vol. 23, No. 2, 2008, p. 186-190.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Evaluation of oxidative stress, antioxidants and prolactin in infertile women

AU - Bhaskar S, Veena

AU - Upadhya, Sharmila

AU - Adiga, Satish Kumar

AU - Kumar N, Pratap

PY - 2008

Y1 - 2008

N2 - The objective of the study was to estimate the serum concentrations of oxidative stress markers- lipid hydroperoxide (MDA-Malondialdehyde), lactate dehydrogenase (LDH), nitrite; and ferric reducing antioxidant power (FRAP) - a measure of total antioxidant capacity in serum. Serum nitrite levels were high in fertile women than in infertile women (p<0.001), whereas MDA was high in infertile women than in fertile group (p<0.018). On classifying the entire group of women with infertility based on the etiology, serum MDA and LDH levels were higher in women with infertility due to unexplained factor than in women with other causes contributing to infertility compared to controls (p<0.001, p<0.02). A positive correlation among serum prolactin and nitrite suggested that hyperprolactinemia could contribute to infertility by inducing oxidative damage. Serum FRAP levels showed no significant difference in the groups studied. Lipid peroxidation was high in women with unexplained infertility which may be due to hyperprolactinemia.

AB - The objective of the study was to estimate the serum concentrations of oxidative stress markers- lipid hydroperoxide (MDA-Malondialdehyde), lactate dehydrogenase (LDH), nitrite; and ferric reducing antioxidant power (FRAP) - a measure of total antioxidant capacity in serum. Serum nitrite levels were high in fertile women than in infertile women (p<0.001), whereas MDA was high in infertile women than in fertile group (p<0.018). On classifying the entire group of women with infertility based on the etiology, serum MDA and LDH levels were higher in women with infertility due to unexplained factor than in women with other causes contributing to infertility compared to controls (p<0.001, p<0.02). A positive correlation among serum prolactin and nitrite suggested that hyperprolactinemia could contribute to infertility by inducing oxidative damage. Serum FRAP levels showed no significant difference in the groups studied. Lipid peroxidation was high in women with unexplained infertility which may be due to hyperprolactinemia.

UR - http://www.scopus.com/inward/record.url?scp=51349086743&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=51349086743&partnerID=8YFLogxK

U2 - 10.1007/s12291-008-0041-3

DO - 10.1007/s12291-008-0041-3

M3 - Article

VL - 23

SP - 186

EP - 190

JO - Indian Journal of Clinical Biochemistry

JF - Indian Journal of Clinical Biochemistry

SN - 0970-1915

IS - 2

ER -