Evaluation of placenta in foetal demise and foetal growth restriction

Ujwala Ch, Shyamala Guruvare, Sudha S. Bhat, Lavanya Rai, Sugandhi Rao

Research output: Contribution to journalArticle

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Abstract

Aim: The study objective was to evaluate the pathological changes of the placenta in foetal death and foetal growth restriction and to find correlation of the findings with clinical causes. Setting and Design: Prospective study at a tertiary care hospital. Material and Methods: Gross and histopathological examinations of the placentae were carried out in pregnancies with foetal demise (IUD) and Foetal Growth Restriction (FGR). Statistical analysis: SPSS, version 11.5. Results: Placentae of twenty seven women with foetal demise and of equal number of women with foetal growth restriction were studied. Placental weight was less than 10th percentile in 61.5% women in IUD group and in 93% women in the FGR group. Gross examination of placentae showed abnormalities in 12 (44%) women of IUD group and in 16 (59%) women of FGR group. Histopathological abnormalities were observed in 74.1% women of the IUD group and in 66.7% women of FGR group. Placental histopathology correlated with clinical risk factors in 60% women of IUD group and in 40% women of FGR group. Among the women with no clinically explainable cause for IUD and FGR, 86% and 57% had placental histopathological abnormalities respectively. Conclusion: The histopathological abnormalities of the placenta can be used to document the clinical causes of foetal demise and growth restriction; it may explain the causes in cases of clinically unexplained foetal demise and foetal growth restriction.

Original languageEnglish
Pages (from-to)2530-2533
Number of pages4
JournalJournal of Clinical and Diagnostic Research
Volume7
Issue number11
DOIs
Publication statusPublished - 10-11-2013

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Fetal Death
Fetal Development
Placenta
Tertiary Healthcare
Tertiary Care Centers
Statistical methods
Prospective Studies

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

Ch, Ujwala ; Guruvare, Shyamala ; Bhat, Sudha S. ; Rai, Lavanya ; Rao, Sugandhi. / Evaluation of placenta in foetal demise and foetal growth restriction. In: Journal of Clinical and Diagnostic Research. 2013 ; Vol. 7, No. 11. pp. 2530-2533.
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abstract = "Aim: The study objective was to evaluate the pathological changes of the placenta in foetal death and foetal growth restriction and to find correlation of the findings with clinical causes. Setting and Design: Prospective study at a tertiary care hospital. Material and Methods: Gross and histopathological examinations of the placentae were carried out in pregnancies with foetal demise (IUD) and Foetal Growth Restriction (FGR). Statistical analysis: SPSS, version 11.5. Results: Placentae of twenty seven women with foetal demise and of equal number of women with foetal growth restriction were studied. Placental weight was less than 10th percentile in 61.5{\%} women in IUD group and in 93{\%} women in the FGR group. Gross examination of placentae showed abnormalities in 12 (44{\%}) women of IUD group and in 16 (59{\%}) women of FGR group. Histopathological abnormalities were observed in 74.1{\%} women of the IUD group and in 66.7{\%} women of FGR group. Placental histopathology correlated with clinical risk factors in 60{\%} women of IUD group and in 40{\%} women of FGR group. Among the women with no clinically explainable cause for IUD and FGR, 86{\%} and 57{\%} had placental histopathological abnormalities respectively. Conclusion: The histopathological abnormalities of the placenta can be used to document the clinical causes of foetal demise and growth restriction; it may explain the causes in cases of clinically unexplained foetal demise and foetal growth restriction.",
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Evaluation of placenta in foetal demise and foetal growth restriction. / Ch, Ujwala; Guruvare, Shyamala; Bhat, Sudha S.; Rai, Lavanya; Rao, Sugandhi.

In: Journal of Clinical and Diagnostic Research, Vol. 7, No. 11, 10.11.2013, p. 2530-2533.

Research output: Contribution to journalArticle

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AU - Ch, Ujwala

AU - Guruvare, Shyamala

AU - Bhat, Sudha S.

AU - Rai, Lavanya

AU - Rao, Sugandhi

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AB - Aim: The study objective was to evaluate the pathological changes of the placenta in foetal death and foetal growth restriction and to find correlation of the findings with clinical causes. Setting and Design: Prospective study at a tertiary care hospital. Material and Methods: Gross and histopathological examinations of the placentae were carried out in pregnancies with foetal demise (IUD) and Foetal Growth Restriction (FGR). Statistical analysis: SPSS, version 11.5. Results: Placentae of twenty seven women with foetal demise and of equal number of women with foetal growth restriction were studied. Placental weight was less than 10th percentile in 61.5% women in IUD group and in 93% women in the FGR group. Gross examination of placentae showed abnormalities in 12 (44%) women of IUD group and in 16 (59%) women of FGR group. Histopathological abnormalities were observed in 74.1% women of the IUD group and in 66.7% women of FGR group. Placental histopathology correlated with clinical risk factors in 60% women of IUD group and in 40% women of FGR group. Among the women with no clinically explainable cause for IUD and FGR, 86% and 57% had placental histopathological abnormalities respectively. Conclusion: The histopathological abnormalities of the placenta can be used to document the clinical causes of foetal demise and growth restriction; it may explain the causes in cases of clinically unexplained foetal demise and foetal growth restriction.

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