Evaluation of retinal thickness in neurodegenerative diseases using spectral domain optical coherence tomography

Bindu Madhavi Manapragada, Shobha G. Pai, Susan D. Souza, Madhurima K. Nayak

Research output: Contribution to journalArticle

Abstract

Introduction: Neurodegenerative diseases are characterised by axonal lesions throughout the central nervous system, including the eye with changes in macular thickness and Retinal Nerve Fiber Layer (RNFL) on histopathologic evaluation. Optical coherence tomography facilitates retina as a surrogate measure of neurodegenerative disease activity. Aim: To evaluate macular thickness and retinal nerve fiber layer thickness in patients with neurodegenerative diseases using spectral domain optical coherence tomography (SD-OCT). Materials and Methods: An analytical observational case control study was carried out over a period of two years. Cases consisted of patients (n=20) with neurodegenerative disorders and controls were age and sex matched healthy individuals. RNFL thickness was measured using the SD OCT. The visual functions tested included the Best Corrected Visual Acuity (BCVA) and colour vision. Fundus examination was done to look for any gross retinal pathologies. All these tests were carried out for cases and controls once during the study. Statistical data analysis was performed by using Mann-Whitney U tests. SPSS for windows, version 17.0 was used to do the analysis. p-values smaller than 0.05 were considered significant. Results: The study included 13 cases of central neurodegenerative diseases and 7 cases of peripheral neurodegenerative diseases. Mean duration of disease in cases was 37.85 months with 11 cases having more than 24 months duration and 9 cases having less than 24 months duration. The mean right eye average (RNFL) thickness in cases was 87.05 µm and that of control was 87.40 µm (p=0.932). The mean left eye average retinal nerve fiber layer thickness in cases was 86.47 µm and control was 89.26 µm (p=0.419). The mean macular cube average thickness of right eye was 271.05 µm in cases and 270.85 µm in controls. The mean macular cube average thickness of left eye was 266.63 µm in cases and 269.42 µm in controls. Conclusion: Retinal segmentation techniques extend the utility of OCT to neurodegenerative disorders, enabling the in vivo objective assessment of retinal neurons in addition to axonal integrity.

Original languageEnglish
Pages (from-to)NC05-NC08
JournalJournal of Clinical and Diagnostic Research
Volume12
Issue number8
DOIs
Publication statusPublished - 01-08-2018

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Neurodegenerative diseases
Optical tomography
Optical Coherence Tomography
Neurodegenerative Diseases
Nerve Fibers
Fibers
Color vision
Retinal Neurons
Color Vision
Statistical Data Interpretation
Neurology
Pathology
Nonparametric Statistics
Visual Acuity
Neurons
Retina
Case-Control Studies
Central Nervous System

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

Manapragada, Bindu Madhavi ; Pai, Shobha G. ; Souza, Susan D. ; Nayak, Madhurima K. / Evaluation of retinal thickness in neurodegenerative diseases using spectral domain optical coherence tomography. In: Journal of Clinical and Diagnostic Research. 2018 ; Vol. 12, No. 8. pp. NC05-NC08.
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Evaluation of retinal thickness in neurodegenerative diseases using spectral domain optical coherence tomography. / Manapragada, Bindu Madhavi; Pai, Shobha G.; Souza, Susan D.; Nayak, Madhurima K.

In: Journal of Clinical and Diagnostic Research, Vol. 12, No. 8, 01.08.2018, p. NC05-NC08.

Research output: Contribution to journalArticle

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