Introduction: The presence of pulpal fluid can influence dentin bonding. This study aimed to evaluate the shear bond strength of universal dental adhesives under simulated intrapulpal pressure. Materials and Methods: Forty intact maxillary premolars were distributed into four groups (Group 1 - 3M ESPE Adper Single Bond 2 total etch adhesive, Group 2 - 3M ESPE Single Bond Universal, Group 3 - Prime and Bond universal adhesive, and Group 4 - Ivoclar Tetric N Bond Universal). Adhesive restorative procedures were carried under intrapulpal pressure simulation following which it was subjected to a shear load of 0.5 mm/min. Fracture mode analysis was performed using a stereomicroscope. The data obtained were subjected to ANOVA and Tukey post hoc test with a P < 0.05. Results: Highest bond strength was exhibited by Group 3 (7.01 ± 2.02 MPa) and least by Group 1 (5.36 ± 3.03 MPa). However, there were no statistical differences among the groups. Group 1 and 2 showed mostly cohesive failure, whereas Group 3 and 4 showed mixed failure. Conclusion: The results demonstrated that the experimental universal adhesive agents exhibited comparative shear bond strength when subjected to pulpal pressure. Pulpal pressure has a significant effect on bond strength.
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