Evaluation of the antioxidant potential of NR-ANX-C (a polyherbal formulation) and its individual constituents in reversing haloperidol-induced catalepsy in mice

Albina Arjuman, Vinod Nair, H. N. Gopalakrishna, M. Nandini

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective: To evaluate the possible role of the antioxidant activity of the polyherbal formulation, NR-ANX-C and its individual components in reversing haloperidol-induced catalepsy in Swiss albino mice. Materials and Methods: Catalepsy was induced with haloperidol (1 mg/kg i.p) in 13 groups of male albino mice (n = 6/group). Three groups received NR-ANX-C (10, 25, 50 mg/kg), three groups received Withania somnifera (1.7, 4.25, 8.5 mg/kg), another three groups Ocimum sanctum (1.7, 4.25, 8.5 mg/kg), three other groups Camellia sinensis (3.4, 8.5, 17 mg/kg) and one group received the vehicle (1% Gum acacia) orally, 30 minutes prior to haloperidol administration, for a duration of seven days. Animals were sacrificed on the seventh day and superoxide dismutase (SOD) activity was estimated in the brain. Results: A significant (P < 0.01) reduction in the cataleptic scores was observed in all the drug-treated groups as compared to the control, with maximum reduction in the NR-ANX-C 25 mg/kg group. Similarly, a reduction in SOD activity was observed in the NR-ANX-C-, O. sanctum- and the W. somnifera-treated groups. An increase in SOD activity was observed in the C. sinensis-treated groups. Conclusion: With the exception of C. sinensis, the antioxidant potential of NR-ANX-C and its individual constituents has contributed to the reduction in the oxidative stress and the catalepsy induced by haloperidol administration.

Original languageEnglish
Pages (from-to)151-154
Number of pages4
JournalIndian Journal of Pharmacology
Volume39
Issue number3
Publication statusPublished - 01-05-2007

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Catalepsy
Haloperidol
Camellia sinensis
Antioxidants
Withania
Superoxide Dismutase
Gum Arabic
Oxidative Stress
NR-ANX-C
Brain
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)

Cite this

@article{12fac185050d4967917dceab1faefd67,
title = "Evaluation of the antioxidant potential of NR-ANX-C (a polyherbal formulation) and its individual constituents in reversing haloperidol-induced catalepsy in mice",
abstract = "Objective: To evaluate the possible role of the antioxidant activity of the polyherbal formulation, NR-ANX-C and its individual components in reversing haloperidol-induced catalepsy in Swiss albino mice. Materials and Methods: Catalepsy was induced with haloperidol (1 mg/kg i.p) in 13 groups of male albino mice (n = 6/group). Three groups received NR-ANX-C (10, 25, 50 mg/kg), three groups received Withania somnifera (1.7, 4.25, 8.5 mg/kg), another three groups Ocimum sanctum (1.7, 4.25, 8.5 mg/kg), three other groups Camellia sinensis (3.4, 8.5, 17 mg/kg) and one group received the vehicle (1{\%} Gum acacia) orally, 30 minutes prior to haloperidol administration, for a duration of seven days. Animals were sacrificed on the seventh day and superoxide dismutase (SOD) activity was estimated in the brain. Results: A significant (P < 0.01) reduction in the cataleptic scores was observed in all the drug-treated groups as compared to the control, with maximum reduction in the NR-ANX-C 25 mg/kg group. Similarly, a reduction in SOD activity was observed in the NR-ANX-C-, O. sanctum- and the W. somnifera-treated groups. An increase in SOD activity was observed in the C. sinensis-treated groups. Conclusion: With the exception of C. sinensis, the antioxidant potential of NR-ANX-C and its individual constituents has contributed to the reduction in the oxidative stress and the catalepsy induced by haloperidol administration.",
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Evaluation of the antioxidant potential of NR-ANX-C (a polyherbal formulation) and its individual constituents in reversing haloperidol-induced catalepsy in mice. / Arjuman, Albina; Nair, Vinod; Gopalakrishna, H. N.; Nandini, M.

In: Indian Journal of Pharmacology, Vol. 39, No. 3, 01.05.2007, p. 151-154.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Evaluation of the antioxidant potential of NR-ANX-C (a polyherbal formulation) and its individual constituents in reversing haloperidol-induced catalepsy in mice

AU - Arjuman, Albina

AU - Nair, Vinod

AU - Gopalakrishna, H. N.

AU - Nandini, M.

PY - 2007/5/1

Y1 - 2007/5/1

N2 - Objective: To evaluate the possible role of the antioxidant activity of the polyherbal formulation, NR-ANX-C and its individual components in reversing haloperidol-induced catalepsy in Swiss albino mice. Materials and Methods: Catalepsy was induced with haloperidol (1 mg/kg i.p) in 13 groups of male albino mice (n = 6/group). Three groups received NR-ANX-C (10, 25, 50 mg/kg), three groups received Withania somnifera (1.7, 4.25, 8.5 mg/kg), another three groups Ocimum sanctum (1.7, 4.25, 8.5 mg/kg), three other groups Camellia sinensis (3.4, 8.5, 17 mg/kg) and one group received the vehicle (1% Gum acacia) orally, 30 minutes prior to haloperidol administration, for a duration of seven days. Animals were sacrificed on the seventh day and superoxide dismutase (SOD) activity was estimated in the brain. Results: A significant (P < 0.01) reduction in the cataleptic scores was observed in all the drug-treated groups as compared to the control, with maximum reduction in the NR-ANX-C 25 mg/kg group. Similarly, a reduction in SOD activity was observed in the NR-ANX-C-, O. sanctum- and the W. somnifera-treated groups. An increase in SOD activity was observed in the C. sinensis-treated groups. Conclusion: With the exception of C. sinensis, the antioxidant potential of NR-ANX-C and its individual constituents has contributed to the reduction in the oxidative stress and the catalepsy induced by haloperidol administration.

AB - Objective: To evaluate the possible role of the antioxidant activity of the polyherbal formulation, NR-ANX-C and its individual components in reversing haloperidol-induced catalepsy in Swiss albino mice. Materials and Methods: Catalepsy was induced with haloperidol (1 mg/kg i.p) in 13 groups of male albino mice (n = 6/group). Three groups received NR-ANX-C (10, 25, 50 mg/kg), three groups received Withania somnifera (1.7, 4.25, 8.5 mg/kg), another three groups Ocimum sanctum (1.7, 4.25, 8.5 mg/kg), three other groups Camellia sinensis (3.4, 8.5, 17 mg/kg) and one group received the vehicle (1% Gum acacia) orally, 30 minutes prior to haloperidol administration, for a duration of seven days. Animals were sacrificed on the seventh day and superoxide dismutase (SOD) activity was estimated in the brain. Results: A significant (P < 0.01) reduction in the cataleptic scores was observed in all the drug-treated groups as compared to the control, with maximum reduction in the NR-ANX-C 25 mg/kg group. Similarly, a reduction in SOD activity was observed in the NR-ANX-C-, O. sanctum- and the W. somnifera-treated groups. An increase in SOD activity was observed in the C. sinensis-treated groups. Conclusion: With the exception of C. sinensis, the antioxidant potential of NR-ANX-C and its individual constituents has contributed to the reduction in the oxidative stress and the catalepsy induced by haloperidol administration.

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