Evaluation of the effect of Glycyrrhiza glabra linn root extract on spatial learning and passive avoidance response in rats

V. Ravichandra, Ahalya Devi, S. Adiga, K. S. Rai

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The roots and rhizomes of Glycyrrhiza glabra (Leguminosae) have been used in the traditional system of medicine for their antiinflammatory, antiulcer, expectorant and antimicrobial activities.They are also reported to have anxiolytic and antidepressant properties in mice.The present study was under taken to investigate the effect of Glycyrrhiza glabra on learning and memory in rats.Spatial learning T-maze and passive avoidance paradigm were employed to test learning and memory.Three doses of(100,200,300mg/ kg p.o) of the aqueous extract of Glycyrrhiza glabra were administered for 15 days in separate group of animals. The aqueous extract significantly improved spatial learning performance and retention of memory in rats. Furthermore 300mg/kg p.o of this extract significantly reversed the amnesia induced by scopalamine(0.5mg/kg i.p.)Anti oxidant property of Glycyrrhiza glabra may be contributing favourably to the memory enhancement effect.Since scopolamine induced amnesia was reversed by Glycyrrhiza glabra, it is possible that the beneficial effect on learning and memory was due to facilitation of cholinergic.

Original languageEnglish
Pages (from-to)214-219
Number of pages6
JournalIndian Drugs
Volume44
Issue number3
Publication statusPublished - 01-03-2007

Fingerprint

Glycyrrhiza
Amnesia
Learning
Expectorants
Rhizome
Scopolamine Hydrobromide
Anti-Anxiety Agents
Traditional Medicine
Systems Analysis
Oxidants
Fabaceae
Cholinergic Agents
Antidepressive Agents
Anti-Inflammatory Agents
Spatial Learning

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery

Cite this

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Evaluation of the effect of Glycyrrhiza glabra linn root extract on spatial learning and passive avoidance response in rats. / Ravichandra, V.; Devi, Ahalya; Adiga, S.; Rai, K. S.

In: Indian Drugs, Vol. 44, No. 3, 01.03.2007, p. 214-219.

Research output: Contribution to journalArticle

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