Evaluation of the established non-MHC multiple sclerosis loci in an Indian population

Lekha Pandit, Maria Ban, Stephen Sawcer, Bhim Singhal, Shyam Nair, Kurupath Radhakrishnan, Rajesh Shetty, Z. Misri, Suresh Hegde, Irruvathur Gopalakrishna Bhat

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Abstract

Background: Multiple sclerosis (MS) is a chronic demyelinating neurodegenerative disorder with a strong genetic component. Objective: The prevalence of MS in India is low compared with white populations of Northern European descent. Methods: In order to ascertain whether disease susceptibility genes are the same across different populations, we completed the first investigation in the Indian MS population of 15 MS loci outside of the major histocompatibility (MHC) region that were previously identified and validated with MS susceptibility through genome-wide association and replication studies in white populations. Results: In total, 197 Indian patients and 197 unrelated controls were analyzed. The most associated single nucleotide polymorphism (SNP) within this study was rs6897932 in the IL7R gene, which showed a strong protective effect in this data set (rs 6897932, OR = 0.5543, 95% CI = 0.37-0.78, p = 0.0009727). Two other SNPs were nominally associated with MS in this dataset, namely CLEC16A rs 12708716 (p = 0.0082, OR = 1.478, 95% CI = 1.106-1.975) and CD226 rs763361 (p = 0.03971, OR = 1.353, CI = 1.014-1.805). For the majority of the remaining SNPs (7/14), the trend for association was in the same direction as in previous studies in the white population. Conclusions: Although the power of this study was limited, our preliminary data suggest that disease susceptibility genes in MS in the Indian population may be similar to those of western populations.

Original languageEnglish
Pages (from-to)139-143
Number of pages5
JournalMultiple Sclerosis Journal
Volume17
Issue number2
DOIs
Publication statusPublished - 01-01-2011

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Histocompatibility
Multiple Sclerosis
Population
Single Nucleotide Polymorphism
Disease Susceptibility
Genes
Genome-Wide Association Study
Demyelinating Diseases
Neurodegenerative Diseases
India

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Pandit, L., Ban, M., Sawcer, S., Singhal, B., Nair, S., Radhakrishnan, K., ... Bhat, I. G. (2011). Evaluation of the established non-MHC multiple sclerosis loci in an Indian population. Multiple Sclerosis Journal, 17(2), 139-143. https://doi.org/10.1177/1352458510384011
Pandit, Lekha ; Ban, Maria ; Sawcer, Stephen ; Singhal, Bhim ; Nair, Shyam ; Radhakrishnan, Kurupath ; Shetty, Rajesh ; Misri, Z. ; Hegde, Suresh ; Bhat, Irruvathur Gopalakrishna. / Evaluation of the established non-MHC multiple sclerosis loci in an Indian population. In: Multiple Sclerosis Journal. 2011 ; Vol. 17, No. 2. pp. 139-143.
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Pandit, L, Ban, M, Sawcer, S, Singhal, B, Nair, S, Radhakrishnan, K, Shetty, R, Misri, Z, Hegde, S & Bhat, IG 2011, 'Evaluation of the established non-MHC multiple sclerosis loci in an Indian population', Multiple Sclerosis Journal, vol. 17, no. 2, pp. 139-143. https://doi.org/10.1177/1352458510384011

Evaluation of the established non-MHC multiple sclerosis loci in an Indian population. / Pandit, Lekha; Ban, Maria; Sawcer, Stephen; Singhal, Bhim; Nair, Shyam; Radhakrishnan, Kurupath; Shetty, Rajesh; Misri, Z.; Hegde, Suresh; Bhat, Irruvathur Gopalakrishna.

In: Multiple Sclerosis Journal, Vol. 17, No. 2, 01.01.2011, p. 139-143.

Research output: Contribution to journalArticle

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T1 - Evaluation of the established non-MHC multiple sclerosis loci in an Indian population

AU - Pandit, Lekha

AU - Ban, Maria

AU - Sawcer, Stephen

AU - Singhal, Bhim

AU - Nair, Shyam

AU - Radhakrishnan, Kurupath

AU - Shetty, Rajesh

AU - Misri, Z.

AU - Hegde, Suresh

AU - Bhat, Irruvathur Gopalakrishna

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N2 - Background: Multiple sclerosis (MS) is a chronic demyelinating neurodegenerative disorder with a strong genetic component. Objective: The prevalence of MS in India is low compared with white populations of Northern European descent. Methods: In order to ascertain whether disease susceptibility genes are the same across different populations, we completed the first investigation in the Indian MS population of 15 MS loci outside of the major histocompatibility (MHC) region that were previously identified and validated with MS susceptibility through genome-wide association and replication studies in white populations. Results: In total, 197 Indian patients and 197 unrelated controls were analyzed. The most associated single nucleotide polymorphism (SNP) within this study was rs6897932 in the IL7R gene, which showed a strong protective effect in this data set (rs 6897932, OR = 0.5543, 95% CI = 0.37-0.78, p = 0.0009727). Two other SNPs were nominally associated with MS in this dataset, namely CLEC16A rs 12708716 (p = 0.0082, OR = 1.478, 95% CI = 1.106-1.975) and CD226 rs763361 (p = 0.03971, OR = 1.353, CI = 1.014-1.805). For the majority of the remaining SNPs (7/14), the trend for association was in the same direction as in previous studies in the white population. Conclusions: Although the power of this study was limited, our preliminary data suggest that disease susceptibility genes in MS in the Indian population may be similar to those of western populations.

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