Evaluation of the radioprotective effect of the leaf extract of Syzygium cumini (Jamun) in mice exposed to a lethal dose of γ-irradiation

Ganesh Chandra Jagetia, Manjeshwar Shrinath Baliga

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

The effects of various concentrations (5, 10, 20, 30, 40, 50, 60, and 80 mg/kg body weight (b.wt.) of the leaf extracts of Syzygium cumini Linn, and Eugenia cumini (SCE, black plum, Jamun, family Myrtaceae) on the radiation-induced sickness and mortality in mice exposed to 10 Gy γ-irradiation were studied. The treatment of mice with different doses of SCE, consecutively for five days before irradation, delayed the onset of mortality and reduced the symptoms of radiation sickness when compared with the nondrug-treated irradiated controls. All doses of SCE provied protection against the gastrointestinal death increasing the survival by 66.66% after treatment with 20, 30, and 40 mg/kg SCE versus a 12% survival in the irradiated control group (oil + irradiation). Similarly, SCE provided protection against the radiation-induced bone marrow death in mice treated with 10-60 mg/kg b.wt. of SCE. However, the best protection was obtained for 30 mg/kg b.wt. SCE, where the number of survivors after 30 days post-irradiation was highest (41.66%) when compared with the other doses of SCE.

Original languageEnglish
Pages (from-to)181-185
Number of pages5
JournalNahrung - Food
Volume47
Issue number3
DOIs
Publication statusPublished - 01-06-2003
Externally publishedYes

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Syzygium cumini
Syzygium
lethal dose
leaf extracts
Radiation Injuries
irradiation
Body Weight
body weight
mice
dosage
Myrtaceae
death
radiation injury
Radiation Protection
Survival
Mortality
plums
bone marrow
signs and symptoms (animals and humans)
Survivors

All Science Journal Classification (ASJC) codes

  • Food Science

Cite this

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title = "Evaluation of the radioprotective effect of the leaf extract of Syzygium cumini (Jamun) in mice exposed to a lethal dose of γ-irradiation",
abstract = "The effects of various concentrations (5, 10, 20, 30, 40, 50, 60, and 80 mg/kg body weight (b.wt.) of the leaf extracts of Syzygium cumini Linn, and Eugenia cumini (SCE, black plum, Jamun, family Myrtaceae) on the radiation-induced sickness and mortality in mice exposed to 10 Gy γ-irradiation were studied. The treatment of mice with different doses of SCE, consecutively for five days before irradation, delayed the onset of mortality and reduced the symptoms of radiation sickness when compared with the nondrug-treated irradiated controls. All doses of SCE provied protection against the gastrointestinal death increasing the survival by 66.66{\%} after treatment with 20, 30, and 40 mg/kg SCE versus a 12{\%} survival in the irradiated control group (oil + irradiation). Similarly, SCE provided protection against the radiation-induced bone marrow death in mice treated with 10-60 mg/kg b.wt. of SCE. However, the best protection was obtained for 30 mg/kg b.wt. SCE, where the number of survivors after 30 days post-irradiation was highest (41.66{\%}) when compared with the other doses of SCE.",
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Evaluation of the radioprotective effect of the leaf extract of Syzygium cumini (Jamun) in mice exposed to a lethal dose of γ-irradiation. / Jagetia, Ganesh Chandra; Baliga, Manjeshwar Shrinath.

In: Nahrung - Food, Vol. 47, No. 3, 01.06.2003, p. 181-185.

Research output: Contribution to journalArticle

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