Background: Insulin resistance (IR) is the major underlying mechanism responsible for metabolic syndrome and HOMA-IR2 is a validated marker of IR. Fasting lipid profile, including triglyceride (TG) and high-density lipoprotein (HDL) cholesterol routinely feature in the outpatient investigation list. Utility of TG/HDL ratio as a surrogate marker for IR was thus studied in healthy young males. Materials and Methods: This cross-sectional study involved 71 young males aged 18-35 years who came for a routine health check in a fasting state. Height, weight, waist circumference were recorded. Fasting plasma glucose (FPG) and lipid profile reports were collected from the laboratory database. Fasting insulin (FI) was estimated by enzyme-linked immunosorbent assay. Body mass index (kg/m2), TG/HDL, TC/HDL, and HOMA-IR2 were calculated. Results: Mean TG/HDL ratio was 3.73 ± 2.03 and HOMA IR2 was above the standard cut off of ≥2.5 units. Subjects were further divided into two groups based on FPG values. TG, low-density lipoprotein, total cholesterol, TG/HDL, TC/HDL, FI and HOMA-IR2 were found to be higher in the pre-diabetes with impaired fasting glycemic subjects. Overall, a statistically significant positive correlation was seen (P = 0.01, r = 0.284) between TG/HDL and HOMA-IR2. Conclusion: TG/HDL ratio was significantly associated with IR and it could be used as an indicator of IR especially in prediabetic subjects having impaired fasting glucose.
All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)