Evaluation of wound healing activity of leaf extract of Alstonia scholaris Linn. In rats

Y. L. Ramachandra, H. V. Sudeep, Padmalatha S. Rai, K. Ramadas

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Alstonia scholaris Linn. (Apocynaceae) is a medium sized tree known for its pharmacological activities like antimicrobial, antimalarial, anticholeric properties etc. The present study was aimed to assess the wound healing potential of crude methanol extract of A. scholaris (leaf) using three types of wound models in rats as incision wound, excision wound and dead space wound. The results were obtained with respect to the parameters such as wound contraction, epithelialization time, tensile strength, hydroxyproline content and granuloma weight. Enhanced wound contraction and decreased epithelialization time were observed in extract-treated animals in excision wound model. The tensile strength of the incision wound was significantly increased in comparison to control group. The granulation tissue weight and hydroxyproline content in the dead space wounds were also increased significantly in treated animals compared with control.

Original languageEnglish
Pages (from-to)390-393
Number of pages4
JournalInternational Journal of Pharmacy and Pharmaceutical Sciences
Volume4
Issue numberSUPPL.1
Publication statusPublished - 2012

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Alstonia
Wound Healing
Wounds and Injuries
Tensile Strength
Hydroxyproline
Apocynaceae
Re-Epithelialization
Weights and Measures
Granulation Tissue
Antimalarials
Granuloma
Complex Mixtures
Methanol
Pharmacology

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

Cite this

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Evaluation of wound healing activity of leaf extract of Alstonia scholaris Linn. In rats. / Ramachandra, Y. L.; Sudeep, H. V.; Rai, Padmalatha S.; Ramadas, K.

In: International Journal of Pharmacy and Pharmaceutical Sciences, Vol. 4, No. SUPPL.1, 2012, p. 390-393.

Research output: Contribution to journalArticle

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