Evidence for genetic linkage between a polymorphism in the GNAS gene and malaria in South Indian population

Himanshu Gupta, Sanica C. Sakharwade, Arshia Angural, Ananthapadmanabha Kotambail, Gopal K. Bhat, Manjunath H. Hande, Sydney C. D'Souza, Purnima Rao, Veena Kumari, Abdul V. Saadi, Kapaettu Satyamoorthy

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The complex imprinted GNAS locus which encodes G-alpha subunit (Gαs) is involved in a number of G-protein coupled signaling pathways in eukaryotic cells. Erythrocyte invasion by Plasmodium falciparum parasites is significantly regulated by protein of GNAS gene. This study was designed to evaluate the association between single nucleotide polymorphisms (SNPs) present in GNAS locus and susceptibility to malaria. In this case control study, individuals affected by P. falciparum malaria (n= 230), Plasmodium vivax malaria (n= 230) and normal controls (n= 230) were tested for the association of eighteen (18) known SNPs to evaluate their role in the onset of the disease. There was no significant difference in genotype frequencies of all the SNPs tested between P. falciparum and P. vivax affected individuals. However, when Bonferroni correction for multiple comparisons were performed as a control, our results demonstrated alleles and genotypes of rs7121: C. >. T (NC_000020.10:g.57478807C. >. T), a silent polymorphism situated in the exon 5, were significantly (p<. 0.05) associated with susceptibility to malaria in the South Indians participants. Our results demonstrate that population specific polymorphisms that exist in GNAS gene may alter the risk of occurrence of malaria.

Original languageEnglish
Pages (from-to)571-577
Number of pages7
JournalActa Tropica
Volume128
Issue number3
DOIs
Publication statusPublished - 12-2013

Fingerprint

Genetic Linkage
malaria
Malaria
Single Nucleotide Polymorphism
linkage (genetics)
genetic polymorphism
Plasmodium falciparum
single nucleotide polymorphism
Plasmodium vivax
Genotype
Population
Vivax Malaria
Genes
genes
Falciparum Malaria
Eukaryotic Cells
GTP-Binding Proteins
Case-Control Studies
Exons
Parasites

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Infectious Diseases

Cite this

Gupta, Himanshu ; Sakharwade, Sanica C. ; Angural, Arshia ; Kotambail, Ananthapadmanabha ; Bhat, Gopal K. ; Hande, Manjunath H. ; D'Souza, Sydney C. ; Rao, Purnima ; Kumari, Veena ; Saadi, Abdul V. ; Satyamoorthy, Kapaettu. / Evidence for genetic linkage between a polymorphism in the GNAS gene and malaria in South Indian population. In: Acta Tropica. 2013 ; Vol. 128, No. 3. pp. 571-577.
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abstract = "The complex imprinted GNAS locus which encodes G-alpha subunit (Gαs) is involved in a number of G-protein coupled signaling pathways in eukaryotic cells. Erythrocyte invasion by Plasmodium falciparum parasites is significantly regulated by protein of GNAS gene. This study was designed to evaluate the association between single nucleotide polymorphisms (SNPs) present in GNAS locus and susceptibility to malaria. In this case control study, individuals affected by P. falciparum malaria (n= 230), Plasmodium vivax malaria (n= 230) and normal controls (n= 230) were tested for the association of eighteen (18) known SNPs to evaluate their role in the onset of the disease. There was no significant difference in genotype frequencies of all the SNPs tested between P. falciparum and P. vivax affected individuals. However, when Bonferroni correction for multiple comparisons were performed as a control, our results demonstrated alleles and genotypes of rs7121: C. >. T (NC_000020.10:g.57478807C. >. T), a silent polymorphism situated in the exon 5, were significantly (p<. 0.05) associated with susceptibility to malaria in the South Indians participants. Our results demonstrate that population specific polymorphisms that exist in GNAS gene may alter the risk of occurrence of malaria.",
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Gupta, H, Sakharwade, SC, Angural, A, Kotambail, A, Bhat, GK, Hande, MH, D'Souza, SC, Rao, P, Kumari, V, Saadi, AV & Satyamoorthy, K 2013, 'Evidence for genetic linkage between a polymorphism in the GNAS gene and malaria in South Indian population', Acta Tropica, vol. 128, no. 3, pp. 571-577. https://doi.org/10.1016/j.actatropica.2013.08.005

Evidence for genetic linkage between a polymorphism in the GNAS gene and malaria in South Indian population. / Gupta, Himanshu; Sakharwade, Sanica C.; Angural, Arshia; Kotambail, Ananthapadmanabha; Bhat, Gopal K.; Hande, Manjunath H.; D'Souza, Sydney C.; Rao, Purnima; Kumari, Veena; Saadi, Abdul V.; Satyamoorthy, Kapaettu.

In: Acta Tropica, Vol. 128, No. 3, 12.2013, p. 571-577.

Research output: Contribution to journalArticle

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T1 - Evidence for genetic linkage between a polymorphism in the GNAS gene and malaria in South Indian population

AU - Gupta, Himanshu

AU - Sakharwade, Sanica C.

AU - Angural, Arshia

AU - Kotambail, Ananthapadmanabha

AU - Bhat, Gopal K.

AU - Hande, Manjunath H.

AU - D'Souza, Sydney C.

AU - Rao, Purnima

AU - Kumari, Veena

AU - Saadi, Abdul V.

AU - Satyamoorthy, Kapaettu

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