Experimental data of fabricated co-crystals of doxorubicin HCl with flavonoids

Prasanna Laxmi, Abhishek Varma, Aravind Pai, Muddukrishna Badamane Sathyanarayana

Research output: Contribution to journalArticle

Abstract

Objectives: This current research work aimed for improvement of the solubility and permeability of poorly permeable Doxorubicin HCl through generating co-crystals. The main goal for the preparation of oral drugs is to decrease the overall cost of healthcare and route of administration is made easy. Methodology: In this study co-crystals of Doxorubicin HCl with Quercetin hydrate and Naringin has been prepared based on ease of hydrogen bond formation. The co-crystal batches of Doxorubicin HCl-Quercetin hydrate in ratio 1:1, 1:2, 2:1 and Doxorubicin HCl-Naringin in ratio 1:1 are prepared by slow solvent evaporation technique. Results and Discussion: The formation of co-crystal was confirmed by PXRD, DSC and FTIR. Doxorubicin HCl with Naringen crystal batch show improved solubility. The dynamic solubility of Doxorubicin HCl-Naringin co-crystal in the ratios 1:1 increased by approximately 9.2-fold as compared to pure drug and Doxorubicin HCl -Quercetin hydrate cocrystal batches.

Original languageEnglish
Pages (from-to)S225-S230
JournalIndian Journal of Pharmaceutical Education and Research
Volume53
Issue number3
DOIs
Publication statusPublished - 01-07-2019

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Flavonoids
Doxorubicin
Quercetin
Solubility
Drug Compounding
Fourier Transform Infrared Spectroscopy
Health Care Costs
Hydrogen
Permeability
Research
Pharmaceutical Preparations
naringin

All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

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Experimental data of fabricated co-crystals of doxorubicin HCl with flavonoids. / Laxmi, Prasanna; Varma, Abhishek; Pai, Aravind; Sathyanarayana, Muddukrishna Badamane.

In: Indian Journal of Pharmaceutical Education and Research, Vol. 53, No. 3, 01.07.2019, p. S225-S230.

Research output: Contribution to journalArticle

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