Exploring potential formulation strategies for chemoprevention of breast cancer: A localized delivery perspective

Aswathi R. Hegde, Ruchira Raychaudhuri, Abhijeet Pandey, Guruprasad Kalthur, Srinivas Mutalik

Research output: Contribution to journalReview articlepeer-review

Abstract

This review focuses on the various formulation approaches that have been explored to achieve localized delivery in breast cancer. The rationale behind the necessity of localized drug delivery has been extensively reviewed. The review also emphasizes the various possible routes for achieving localized drug delivery. Particularly, different types of nanoplatforms like lipid-based drug carriers, polymeric particles, hydrogels, drug conjugates and other formulation strategies like microneedles and drug-eluting implants, which have been used to increase tumor retention and subsequently halt tumor progression, have been deliberated here. In addition, the significant challenges that may be encountered in the delivery of anticancer drugs and the aspects that require careful evaluation for effective localized delivery of chemotherapeutic agents have been discussed.

Original languageEnglish
Pages (from-to)1111-1132
Number of pages22
JournalNanomedicine
Volume16
Issue number13
DOIs
Publication statusPublished - 06-2021

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Materials Science(all)

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