Exploring the potential of laser capture microdissection technology in integrated oral biosciences

A. Thennavan, M. Sharma, C. Chandrashekar, K. Hunter, R. Radhakrishnan

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Laser capture microdissection (LCM) is a high-end research and diagnostic technology that helps in obtaining pure cell populations for the purpose of cell- or lesion-specific genomic and proteomic analysis. Literature search on the application of LCM in oral tissues was made through PubMed. There is ample evidence to substantiate the utility of LCM in understanding the underlying molecular mechanism involving an array of oral physiological and pathological processes, including odontogenesis, taste perception, eruptive tooth movement, oral microbes, and cancers of the mouth and jaw tumors. This review is aimed at exploring the potential application of LCM in oral tissues as a high-throughput tool for integrated oral sciences. The indispensable application of LCM in the construction of lesion-specific genomic libraries with emphasis on some of the novel molecular markers thus discovered is also highlighted.

Original languageEnglish
Pages (from-to)737-748
Number of pages12
JournalOral Diseases
Volume23
Issue number6
DOIs
Publication statusPublished - 01-09-2017

Fingerprint

Laser Capture Microdissection
Technology
Mouth Neoplasms
Jaw Neoplasms
Odontogenesis
Taste Perception
Physiological Phenomena
Tooth Movement Techniques
Genomic Library
Pathologic Processes
PubMed
Proteomics
Research
Population
Neoplasms

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology
  • Dentistry(all)

Cite this

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Exploring the potential of laser capture microdissection technology in integrated oral biosciences. / Thennavan, A.; Sharma, M.; Chandrashekar, C.; Hunter, K.; Radhakrishnan, R.

In: Oral Diseases, Vol. 23, No. 6, 01.09.2017, p. 737-748.

Research output: Contribution to journalReview article

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AU - Radhakrishnan, R.

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