Exposure to Enriched Environment Improves Spatial Learning Performances and Enhances Cell Density but Not Choline Acetyltransferase Activity in the Hippocampus of Ventral Subicular-Lesioned Rats

Anandh Dhanushkodi, B. Bindu, T. R. Raju, Bindu M. Kutty

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The authors demonstrated the efficacy of enriched housing conditions in promoting the behavioral recovery and neuronal survival following subicular lesion in rats. Chemical lesioning of the ventral subiculum impaired the spatial learning performances in rats. The lesion also induced a significant degree of neurodegeneration in the CA1 and CA3 areas of the hippocampus and entorhinal cortex. Exposure to enriched housing conditions improved the behavioral performance and partially attenuated the neurodegeneration in the hippocampus. The choline acetyl transferase (ChAT) activity in the hippocampus remained unchanged following ventral subicular lesion and also following exposure to an enriched environment. The study implicates the effectiveness of activity-dependent neuronal plasticity induced by environmental enrichment in adulthood following brain insult.

Original languageEnglish
Pages (from-to)491-500
Number of pages10
JournalBehavioral Neuroscience
Volume121
Issue number3
DOIs
Publication statusPublished - 06-2007

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience
  • Clinical Psychology

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