Exposure to Enriched Environment Improves Spatial Learning Performances and Enhances Cell Density but Not Choline Acetyltransferase Activity in the Hippocampus of Ventral Subicular-Lesioned Rats

Anandh Dhanushkodi, B. Bindu, T. R. Raju, Bindu M. Kutty

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The authors demonstrated the efficacy of enriched housing conditions in promoting the behavioral recovery and neuronal survival following subicular lesion in rats. Chemical lesioning of the ventral subiculum impaired the spatial learning performances in rats. The lesion also induced a significant degree of neurodegeneration in the CA1 and CA3 areas of the hippocampus and entorhinal cortex. Exposure to enriched housing conditions improved the behavioral performance and partially attenuated the neurodegeneration in the hippocampus. The choline acetyl transferase (ChAT) activity in the hippocampus remained unchanged following ventral subicular lesion and also following exposure to an enriched environment. The study implicates the effectiveness of activity-dependent neuronal plasticity induced by environmental enrichment in adulthood following brain insult.

Original languageEnglish
Pages (from-to)491-500
Number of pages10
JournalBehavioral Neuroscience
Volume121
Issue number3
DOIs
Publication statusPublished - 06-2007

Fingerprint

Choline O-Acetyltransferase
Hippocampus
Cell Count
Entorhinal Cortex
Neuronal Plasticity
Transferases
Choline
Spatial Learning
Brain

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience
  • Clinical Psychology

Cite this

@article{8195928477734613821de7f4ff0b7f2d,
title = "Exposure to Enriched Environment Improves Spatial Learning Performances and Enhances Cell Density but Not Choline Acetyltransferase Activity in the Hippocampus of Ventral Subicular-Lesioned Rats",
abstract = "The authors demonstrated the efficacy of enriched housing conditions in promoting the behavioral recovery and neuronal survival following subicular lesion in rats. Chemical lesioning of the ventral subiculum impaired the spatial learning performances in rats. The lesion also induced a significant degree of neurodegeneration in the CA1 and CA3 areas of the hippocampus and entorhinal cortex. Exposure to enriched housing conditions improved the behavioral performance and partially attenuated the neurodegeneration in the hippocampus. The choline acetyl transferase (ChAT) activity in the hippocampus remained unchanged following ventral subicular lesion and also following exposure to an enriched environment. The study implicates the effectiveness of activity-dependent neuronal plasticity induced by environmental enrichment in adulthood following brain insult.",
author = "Anandh Dhanushkodi and B. Bindu and Raju, {T. R.} and Kutty, {Bindu M.}",
year = "2007",
month = "6",
doi = "10.1037/0735-7044.121.3.491",
language = "English",
volume = "121",
pages = "491--500",
journal = "Behavioral Neuroscience",
issn = "0735-7044",
publisher = "American Psychological Association Inc.",
number = "3",

}

TY - JOUR

T1 - Exposure to Enriched Environment Improves Spatial Learning Performances and Enhances Cell Density but Not Choline Acetyltransferase Activity in the Hippocampus of Ventral Subicular-Lesioned Rats

AU - Dhanushkodi, Anandh

AU - Bindu, B.

AU - Raju, T. R.

AU - Kutty, Bindu M.

PY - 2007/6

Y1 - 2007/6

N2 - The authors demonstrated the efficacy of enriched housing conditions in promoting the behavioral recovery and neuronal survival following subicular lesion in rats. Chemical lesioning of the ventral subiculum impaired the spatial learning performances in rats. The lesion also induced a significant degree of neurodegeneration in the CA1 and CA3 areas of the hippocampus and entorhinal cortex. Exposure to enriched housing conditions improved the behavioral performance and partially attenuated the neurodegeneration in the hippocampus. The choline acetyl transferase (ChAT) activity in the hippocampus remained unchanged following ventral subicular lesion and also following exposure to an enriched environment. The study implicates the effectiveness of activity-dependent neuronal plasticity induced by environmental enrichment in adulthood following brain insult.

AB - The authors demonstrated the efficacy of enriched housing conditions in promoting the behavioral recovery and neuronal survival following subicular lesion in rats. Chemical lesioning of the ventral subiculum impaired the spatial learning performances in rats. The lesion also induced a significant degree of neurodegeneration in the CA1 and CA3 areas of the hippocampus and entorhinal cortex. Exposure to enriched housing conditions improved the behavioral performance and partially attenuated the neurodegeneration in the hippocampus. The choline acetyl transferase (ChAT) activity in the hippocampus remained unchanged following ventral subicular lesion and also following exposure to an enriched environment. The study implicates the effectiveness of activity-dependent neuronal plasticity induced by environmental enrichment in adulthood following brain insult.

UR - http://www.scopus.com/inward/record.url?scp=34548819394&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34548819394&partnerID=8YFLogxK

U2 - 10.1037/0735-7044.121.3.491

DO - 10.1037/0735-7044.121.3.491

M3 - Article

VL - 121

SP - 491

EP - 500

JO - Behavioral Neuroscience

JF - Behavioral Neuroscience

SN - 0735-7044

IS - 3

ER -