Expression of E-cadherin in primary oral squamous cell carcinoma and metastatic lymph nodes

An immunohistochemical study

Gurkiran Kaur, Sunitha Carnelio, Nirmala Rao, Laxmi Rao

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Background: E-cadherin plays an important role in cell-to-cell adhesion and cell motility and its loss is associated with oral squamous cell carcinoma (OSCC) progression. The aim of this study was to determine the expression of E-cadherin in various grades of OSCC and to correlate changes in the expression between these various grades and metastatic lymph nodes. Materials and Methods: Immunohistochemistry (IHC) was used to detect E-cadherin expression in normal oral mucosa, primary OSCC ( n = 37), and metastatic lymph nodes ( n = 10). E-cadherin immunoreactivity was correlated with grades of differentiation and with clinicopathological features. Results: E-cadherin immunoreactivity was found to inversely correlate with the loss of cell differentiation. The expression of E-cadherin decreased significantly in advanced cases of OSCC. However, increase in E-cadherin immunoreactivity was seen in early lesions, that is, in well differentiated ( n = 9) and moderately differentiated OSCC ( n = 13). Furthermore, E-cadherin was negative in majority of metastatic lymph nodes (7/10). Conclusions: Loss of the cell adhesion and E-cadherin plays an important role in progression of OSCC, that is, down regulation of its expression is associated with de-differentiation and metastasis.

Original languageEnglish
Pages (from-to)71-76
Number of pages6
JournalIndian Journal of Dental Research
Volume20
Issue number1
DOIs
Publication statusPublished - 01-01-2009

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Cadherins
Squamous Cell Carcinoma
Lymph Nodes
Cell Adhesion
Mouth Mucosa
Cell Movement
Cell Differentiation
Down-Regulation
Immunohistochemistry
Neoplasm Metastasis

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Dentistry(all)

Cite this

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abstract = "Background: E-cadherin plays an important role in cell-to-cell adhesion and cell motility and its loss is associated with oral squamous cell carcinoma (OSCC) progression. The aim of this study was to determine the expression of E-cadherin in various grades of OSCC and to correlate changes in the expression between these various grades and metastatic lymph nodes. Materials and Methods: Immunohistochemistry (IHC) was used to detect E-cadherin expression in normal oral mucosa, primary OSCC ( n = 37), and metastatic lymph nodes ( n = 10). E-cadherin immunoreactivity was correlated with grades of differentiation and with clinicopathological features. Results: E-cadherin immunoreactivity was found to inversely correlate with the loss of cell differentiation. The expression of E-cadherin decreased significantly in advanced cases of OSCC. However, increase in E-cadherin immunoreactivity was seen in early lesions, that is, in well differentiated ( n = 9) and moderately differentiated OSCC ( n = 13). Furthermore, E-cadherin was negative in majority of metastatic lymph nodes (7/10). Conclusions: Loss of the cell adhesion and E-cadherin plays an important role in progression of OSCC, that is, down regulation of its expression is associated with de-differentiation and metastasis.",
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Expression of E-cadherin in primary oral squamous cell carcinoma and metastatic lymph nodes : An immunohistochemical study. / Kaur, Gurkiran; Carnelio, Sunitha; Rao, Nirmala; Rao, Laxmi.

In: Indian Journal of Dental Research, Vol. 20, No. 1, 01.01.2009, p. 71-76.

Research output: Contribution to journalArticle

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