Abstract
Aim: To evaluate the expression of laminin in various grades of oral squamous cell carcinoma (OSCC) in order to determine whether this protein can be used as a marker for early detection and elucidation of oral cancer. Materials and methods: Immunohistochemical staining for laminin was done on 60 selected archival blocks of histopathologically diagnosed cases of primary OSCC and the laminin expression was compared between the different histopathological grades of primary OSCC. The statistical analysis was performed by using Chi-square (χ square) test and Gaussiantest with a probability of p < 0.05 was considered as significant. Results: It was observed that laminin expression decreased with tumor progression which may be correlated to the tumor aggressiveness. Conclusion: There was a gradual decrease of laminin staining with decreasing cellular differentiation, with differentiated lesions showing a more conspicuous staining of basement membrane glycoprotein than less differentiated lesions. Clinical significance: An understanding of how the extracellular matrix influences tumor development and invasion is fundamental in the development of new prognostic indicators and treatment strategies for oral squamous cell carcinoma.
| Original language | English |
|---|---|
| Pages (from-to) | 194-200 |
| Number of pages | 7 |
| Journal | Journal of Contemporary Dental Practice |
| Volume | 13 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 01-01-2012 |
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All Science Journal Classification (ASJC) codes
- Dentistry(all)
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Expression of extracellular matrix-laminin in oral squamous : Cell carcinoma: An immunohistochemical study. / Koshy, Ajit V.; Rao, Nirmala N.; Kamat, Sushant S.; Kiswani, Kamal; Kapse, Sonam C.; Shaikh, Nahid A.
In: Journal of Contemporary Dental Practice, Vol. 13, No. 2, 01.01.2012, p. 194-200.Research output: Contribution to journal › Article
TY - JOUR
T1 - Expression of extracellular matrix-laminin in oral squamous
T2 - Cell carcinoma: An immunohistochemical study
AU - Koshy, Ajit V.
AU - Rao, Nirmala N.
AU - Kamat, Sushant S.
AU - Kiswani, Kamal
AU - Kapse, Sonam C.
AU - Shaikh, Nahid A.
PY - 2012/1/1
Y1 - 2012/1/1
N2 - Aim: To evaluate the expression of laminin in various grades of oral squamous cell carcinoma (OSCC) in order to determine whether this protein can be used as a marker for early detection and elucidation of oral cancer. Materials and methods: Immunohistochemical staining for laminin was done on 60 selected archival blocks of histopathologically diagnosed cases of primary OSCC and the laminin expression was compared between the different histopathological grades of primary OSCC. The statistical analysis was performed by using Chi-square (χ square) test and Gaussiantest with a probability of p < 0.05 was considered as significant. Results: It was observed that laminin expression decreased with tumor progression which may be correlated to the tumor aggressiveness. Conclusion: There was a gradual decrease of laminin staining with decreasing cellular differentiation, with differentiated lesions showing a more conspicuous staining of basement membrane glycoprotein than less differentiated lesions. Clinical significance: An understanding of how the extracellular matrix influences tumor development and invasion is fundamental in the development of new prognostic indicators and treatment strategies for oral squamous cell carcinoma.
AB - Aim: To evaluate the expression of laminin in various grades of oral squamous cell carcinoma (OSCC) in order to determine whether this protein can be used as a marker for early detection and elucidation of oral cancer. Materials and methods: Immunohistochemical staining for laminin was done on 60 selected archival blocks of histopathologically diagnosed cases of primary OSCC and the laminin expression was compared between the different histopathological grades of primary OSCC. The statistical analysis was performed by using Chi-square (χ square) test and Gaussiantest with a probability of p < 0.05 was considered as significant. Results: It was observed that laminin expression decreased with tumor progression which may be correlated to the tumor aggressiveness. Conclusion: There was a gradual decrease of laminin staining with decreasing cellular differentiation, with differentiated lesions showing a more conspicuous staining of basement membrane glycoprotein than less differentiated lesions. Clinical significance: An understanding of how the extracellular matrix influences tumor development and invasion is fundamental in the development of new prognostic indicators and treatment strategies for oral squamous cell carcinoma.
UR - http://www.scopus.com/inward/record.url?scp=84860736068&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84860736068&partnerID=8YFLogxK
U2 - 10.5005/jp-journals-10024-1120
DO - 10.5005/jp-journals-10024-1120
M3 - Article
VL - 13
SP - 194
EP - 200
JO - Journal of Contemporary Dental Practice
JF - Journal of Contemporary Dental Practice
SN - 1526-3711
IS - 2
ER -