Fabrication of low-cost composite polymer-based micro needle patch for transdermal drug delivery

Eshwari Dathathri, Satyapriya Lal, Mohit Mittal, Goutam Thakur, Shounak De

Research output: Contribution to journalArticle

Abstract

Microneedle delivery patches are an emerging technology to attain painless and sustained delivery through the epidermis of the skin. This study is unique in its attempt to develop polymeric microneedles embedded with drug. Special polymer chitosan with hydrogel forming capability is cross-linked with PVA, a water-soluble polymer with excellent film strengthening ability and loaded with model drug diclofenac sodium. The microneedle patch was fabricated by pouring the chitosan-PVA solution (ratio 1:6) on negative replica of master mold, which upon drying was peeled off to result in the composite film. The film of chitosan-PVA in the ratio 1:6 when tested for mechanical behavior exhibited improved mechanical strength owing to use of PVA, the presence of effective cross-linking of PVA with chitosan was further verified with FTIR. The release from drug-loaded needles was promising, as cross-linking with PVA enabled a sustained drug release of 20.17% at the end of 30 h. The release followed the Higuchi model with Fickian diffusion, indicating a swelling-dependent release. The microneedle prepared using a composite of chitosan-PVA showed promising results indicating its potential to be used as a drug eluting transdermal patch.

Original languageEnglish
JournalApplied Nanoscience (Switzerland)
DOIs
Publication statusAccepted/In press - 01-01-2019

Fingerprint

Transdermal Patch
Chitosan
Drug delivery
needles
Needles
delivery
Polymers
drugs
Costs and Cost Analysis
Fabrication
fabrication
composite materials
Composite materials
polymers
Pharmaceutical Preparations
Costs
Diclofenac
Hydrogel
Composite films
Fourier Transform Infrared Spectroscopy

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Atomic and Molecular Physics, and Optics
  • Materials Science (miscellaneous)
  • Physical and Theoretical Chemistry
  • Cell Biology
  • Electrical and Electronic Engineering

Cite this

@article{8170088762fe4ea8b1720f388562ab0a,
title = "Fabrication of low-cost composite polymer-based micro needle patch for transdermal drug delivery",
abstract = "Microneedle delivery patches are an emerging technology to attain painless and sustained delivery through the epidermis of the skin. This study is unique in its attempt to develop polymeric microneedles embedded with drug. Special polymer chitosan with hydrogel forming capability is cross-linked with PVA, a water-soluble polymer with excellent film strengthening ability and loaded with model drug diclofenac sodium. The microneedle patch was fabricated by pouring the chitosan-PVA solution (ratio 1:6) on negative replica of master mold, which upon drying was peeled off to result in the composite film. The film of chitosan-PVA in the ratio 1:6 when tested for mechanical behavior exhibited improved mechanical strength owing to use of PVA, the presence of effective cross-linking of PVA with chitosan was further verified with FTIR. The release from drug-loaded needles was promising, as cross-linking with PVA enabled a sustained drug release of 20.17{\%} at the end of 30 h. The release followed the Higuchi model with Fickian diffusion, indicating a swelling-dependent release. The microneedle prepared using a composite of chitosan-PVA showed promising results indicating its potential to be used as a drug eluting transdermal patch.",
author = "Eshwari Dathathri and Satyapriya Lal and Mohit Mittal and Goutam Thakur and Shounak De",
year = "2019",
month = "1",
day = "1",
doi = "10.1007/s13204-019-01190-3",
language = "English",
journal = "Applied Nanoscience (Switzerland)",
issn = "2190-5509",
publisher = "Springer Nature",

}

Fabrication of low-cost composite polymer-based micro needle patch for transdermal drug delivery. / Dathathri, Eshwari; Lal, Satyapriya; Mittal, Mohit; Thakur, Goutam; De, Shounak.

In: Applied Nanoscience (Switzerland), 01.01.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Fabrication of low-cost composite polymer-based micro needle patch for transdermal drug delivery

AU - Dathathri, Eshwari

AU - Lal, Satyapriya

AU - Mittal, Mohit

AU - Thakur, Goutam

AU - De, Shounak

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Microneedle delivery patches are an emerging technology to attain painless and sustained delivery through the epidermis of the skin. This study is unique in its attempt to develop polymeric microneedles embedded with drug. Special polymer chitosan with hydrogel forming capability is cross-linked with PVA, a water-soluble polymer with excellent film strengthening ability and loaded with model drug diclofenac sodium. The microneedle patch was fabricated by pouring the chitosan-PVA solution (ratio 1:6) on negative replica of master mold, which upon drying was peeled off to result in the composite film. The film of chitosan-PVA in the ratio 1:6 when tested for mechanical behavior exhibited improved mechanical strength owing to use of PVA, the presence of effective cross-linking of PVA with chitosan was further verified with FTIR. The release from drug-loaded needles was promising, as cross-linking with PVA enabled a sustained drug release of 20.17% at the end of 30 h. The release followed the Higuchi model with Fickian diffusion, indicating a swelling-dependent release. The microneedle prepared using a composite of chitosan-PVA showed promising results indicating its potential to be used as a drug eluting transdermal patch.

AB - Microneedle delivery patches are an emerging technology to attain painless and sustained delivery through the epidermis of the skin. This study is unique in its attempt to develop polymeric microneedles embedded with drug. Special polymer chitosan with hydrogel forming capability is cross-linked with PVA, a water-soluble polymer with excellent film strengthening ability and loaded with model drug diclofenac sodium. The microneedle patch was fabricated by pouring the chitosan-PVA solution (ratio 1:6) on negative replica of master mold, which upon drying was peeled off to result in the composite film. The film of chitosan-PVA in the ratio 1:6 when tested for mechanical behavior exhibited improved mechanical strength owing to use of PVA, the presence of effective cross-linking of PVA with chitosan was further verified with FTIR. The release from drug-loaded needles was promising, as cross-linking with PVA enabled a sustained drug release of 20.17% at the end of 30 h. The release followed the Higuchi model with Fickian diffusion, indicating a swelling-dependent release. The microneedle prepared using a composite of chitosan-PVA showed promising results indicating its potential to be used as a drug eluting transdermal patch.

UR - http://www.scopus.com/inward/record.url?scp=85074663218&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85074663218&partnerID=8YFLogxK

U2 - 10.1007/s13204-019-01190-3

DO - 10.1007/s13204-019-01190-3

M3 - Article

AN - SCOPUS:85074663218

JO - Applied Nanoscience (Switzerland)

JF - Applied Nanoscience (Switzerland)

SN - 2190-5509

ER -