Facile one-pot multicomponent synthesis of 1H-pyrazolo[3,4-b]quinolines using L-proline as a catalyst

Hemant Hegde, Nitinkumar S. Shetty

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

[Figure not available: see fulltext.] An efficient protocol for the synthesis of a new series of 1H-pyrazolo[3,4-b]quinolines has been described. The target compounds have been synthesized by one-pot multicomponent reaction of aniline, aromatic aldehydes, and 5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one using L-proline as an organocatalyst. Structural diversity and high yields of products, broad scope of aromatic aldehydes, simple operation, and short reaction times have been demonstrated as the advantages of the developed synthetic approach.

Original languageEnglish
Pages (from-to)883-886
Number of pages4
JournalChemistry of Heterocyclic Compounds
Volume53
Issue number8
DOIs
Publication statusPublished - 01-08-2017

Fingerprint

Proline
Aldehydes
Catalysts
1H-pyrazolo(3,4-b)quinoline
aniline
phenylmethylpyrazolone

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

Cite this

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Facile one-pot multicomponent synthesis of 1H-pyrazolo[3,4-b]quinolines using L-proline as a catalyst. / Hegde, Hemant; Shetty, Nitinkumar S.

In: Chemistry of Heterocyclic Compounds, Vol. 53, No. 8, 01.08.2017, p. 883-886.

Research output: Contribution to journalArticle

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AB - [Figure not available: see fulltext.] An efficient protocol for the synthesis of a new series of 1H-pyrazolo[3,4-b]quinolines has been described. The target compounds have been synthesized by one-pot multicomponent reaction of aniline, aromatic aldehydes, and 5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3-one using L-proline as an organocatalyst. Structural diversity and high yields of products, broad scope of aromatic aldehydes, simple operation, and short reaction times have been demonstrated as the advantages of the developed synthetic approach.

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