Factors associated with adverse outcome in pediatric febrile neutropenia: Results from a tertiary care hospital

Srujana Gurlinka, B. Nalini, Pushpa Kini, A. Shrikiran, Suneel C. Mundkur

Research output: Contribution to journalArticle

Abstract

Background Febrile neutropenia with childhood cancer alters the outcome significantly. To study the clinical and laboratory parameters, which predict the outcome among cancer patients with febrile neutropenia this study was undertaken. Materials and Methods The study included children less than 18 years with febrile neutropenia episodes. Clinical and hematological / laboratory parameters were recorded during each episode. Hemoglobin, total leucocyte count, platelet count, absolute neutrophil count, absolute monocyte count and serum C- reactive protein (CRP) levels at the onset of febrile neutropenia episode were analyzed as predictors of outcome of febrile neutropenia. The outcome was measured in terms of mortality, duration of fever and need for Intensive care unit (ICU) stay. Results The study consisted of 88 episodes in 40 children with a median (IQR) age of 5.9 (3.79, 10) years. In 67.5% of Children's Leukaemia was the underlying disease. Mean (±SD) hemoglobin concentration was 8.8 ± 1.71 g/dl. Profound neutropenia was seen in 32(36.5%) episodes. Most common infection was lower respiratory infection (30.7%). Absolute monocyte count < 100 cells/cu.mm was found to predict a duration of fever > 7 days (p=0.030).Thrombocytopenia (< 50,000) and CRP (>90 mg/L) were found to be significant predictors of mortality (p <0.001 and 0.017, respectively), and the need for prolonged ICU stay (p =0.027 and p=0.048, respectively). Conclusion Thrombocytopenia and elevated CRP are significant predictors of mortality and the need for prolonged ICU stay, whereas low hemoglobin level, leukopenia and low absolute neutrophil count (ANC) were not associated with of adverse outcome in febrile neutropenia episodes.

Original languageEnglish
Pages (from-to)6447-6455
Number of pages9
JournalInternational Journal of Pediatrics
Volume5
Issue number12
DOIs
Publication statusPublished - 01-12-2017

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Febrile Neutropenia
Tertiary Healthcare
Tertiary Care Centers
Pediatrics
Intensive Care Units
Hemoglobins
Thrombocytopenia
C-Reactive Protein
Mortality
Monocytes
Neutrophils
Leukopenia
Neutropenia
Platelet Count
Leukocyte Count
Respiratory Tract Infections
Blood Proteins
Neoplasms
Leukemia
Fever

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

@article{255f0ad5aeca4d26b043cfe440126817,
title = "Factors associated with adverse outcome in pediatric febrile neutropenia: Results from a tertiary care hospital",
abstract = "Background Febrile neutropenia with childhood cancer alters the outcome significantly. To study the clinical and laboratory parameters, which predict the outcome among cancer patients with febrile neutropenia this study was undertaken. Materials and Methods The study included children less than 18 years with febrile neutropenia episodes. Clinical and hematological / laboratory parameters were recorded during each episode. Hemoglobin, total leucocyte count, platelet count, absolute neutrophil count, absolute monocyte count and serum C- reactive protein (CRP) levels at the onset of febrile neutropenia episode were analyzed as predictors of outcome of febrile neutropenia. The outcome was measured in terms of mortality, duration of fever and need for Intensive care unit (ICU) stay. Results The study consisted of 88 episodes in 40 children with a median (IQR) age of 5.9 (3.79, 10) years. In 67.5{\%} of Children's Leukaemia was the underlying disease. Mean (±SD) hemoglobin concentration was 8.8 ± 1.71 g/dl. Profound neutropenia was seen in 32(36.5{\%}) episodes. Most common infection was lower respiratory infection (30.7{\%}). Absolute monocyte count < 100 cells/cu.mm was found to predict a duration of fever > 7 days (p=0.030).Thrombocytopenia (< 50,000) and CRP (>90 mg/L) were found to be significant predictors of mortality (p <0.001 and 0.017, respectively), and the need for prolonged ICU stay (p =0.027 and p=0.048, respectively). Conclusion Thrombocytopenia and elevated CRP are significant predictors of mortality and the need for prolonged ICU stay, whereas low hemoglobin level, leukopenia and low absolute neutrophil count (ANC) were not associated with of adverse outcome in febrile neutropenia episodes.",
author = "Srujana Gurlinka and B. Nalini and Pushpa Kini and A. Shrikiran and Mundkur, {Suneel C.}",
year = "2017",
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Factors associated with adverse outcome in pediatric febrile neutropenia : Results from a tertiary care hospital. / Gurlinka, Srujana; Nalini, B.; Kini, Pushpa; Shrikiran, A.; Mundkur, Suneel C.

In: International Journal of Pediatrics, Vol. 5, No. 12, 01.12.2017, p. 6447-6455.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Factors associated with adverse outcome in pediatric febrile neutropenia

T2 - Results from a tertiary care hospital

AU - Gurlinka, Srujana

AU - Nalini, B.

AU - Kini, Pushpa

AU - Shrikiran, A.

AU - Mundkur, Suneel C.

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Background Febrile neutropenia with childhood cancer alters the outcome significantly. To study the clinical and laboratory parameters, which predict the outcome among cancer patients with febrile neutropenia this study was undertaken. Materials and Methods The study included children less than 18 years with febrile neutropenia episodes. Clinical and hematological / laboratory parameters were recorded during each episode. Hemoglobin, total leucocyte count, platelet count, absolute neutrophil count, absolute monocyte count and serum C- reactive protein (CRP) levels at the onset of febrile neutropenia episode were analyzed as predictors of outcome of febrile neutropenia. The outcome was measured in terms of mortality, duration of fever and need for Intensive care unit (ICU) stay. Results The study consisted of 88 episodes in 40 children with a median (IQR) age of 5.9 (3.79, 10) years. In 67.5% of Children's Leukaemia was the underlying disease. Mean (±SD) hemoglobin concentration was 8.8 ± 1.71 g/dl. Profound neutropenia was seen in 32(36.5%) episodes. Most common infection was lower respiratory infection (30.7%). Absolute monocyte count < 100 cells/cu.mm was found to predict a duration of fever > 7 days (p=0.030).Thrombocytopenia (< 50,000) and CRP (>90 mg/L) were found to be significant predictors of mortality (p <0.001 and 0.017, respectively), and the need for prolonged ICU stay (p =0.027 and p=0.048, respectively). Conclusion Thrombocytopenia and elevated CRP are significant predictors of mortality and the need for prolonged ICU stay, whereas low hemoglobin level, leukopenia and low absolute neutrophil count (ANC) were not associated with of adverse outcome in febrile neutropenia episodes.

AB - Background Febrile neutropenia with childhood cancer alters the outcome significantly. To study the clinical and laboratory parameters, which predict the outcome among cancer patients with febrile neutropenia this study was undertaken. Materials and Methods The study included children less than 18 years with febrile neutropenia episodes. Clinical and hematological / laboratory parameters were recorded during each episode. Hemoglobin, total leucocyte count, platelet count, absolute neutrophil count, absolute monocyte count and serum C- reactive protein (CRP) levels at the onset of febrile neutropenia episode were analyzed as predictors of outcome of febrile neutropenia. The outcome was measured in terms of mortality, duration of fever and need for Intensive care unit (ICU) stay. Results The study consisted of 88 episodes in 40 children with a median (IQR) age of 5.9 (3.79, 10) years. In 67.5% of Children's Leukaemia was the underlying disease. Mean (±SD) hemoglobin concentration was 8.8 ± 1.71 g/dl. Profound neutropenia was seen in 32(36.5%) episodes. Most common infection was lower respiratory infection (30.7%). Absolute monocyte count < 100 cells/cu.mm was found to predict a duration of fever > 7 days (p=0.030).Thrombocytopenia (< 50,000) and CRP (>90 mg/L) were found to be significant predictors of mortality (p <0.001 and 0.017, respectively), and the need for prolonged ICU stay (p =0.027 and p=0.048, respectively). Conclusion Thrombocytopenia and elevated CRP are significant predictors of mortality and the need for prolonged ICU stay, whereas low hemoglobin level, leukopenia and low absolute neutrophil count (ANC) were not associated with of adverse outcome in febrile neutropenia episodes.

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