Factors associated with no apparent coronary artery disease in patients with type 2 diabetes mellitus for more than 10years of duration: A case control study

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Type 2 diabetes mellitus is an important risk factor in the development of coronary artery disease (CAD) and is often associated with severe disease. However, this risk is not uniform, some patients remain free of CAD even after many years of treatment for diabetes. The present study was aimed to identify the factors that are associated with a favorable CAD profile. Methods: A case-control study of 76 patients with type 2 diabetes mellitus who were on treatment for more than 10years duration and undergoing a coronary angiogram for the evaluation of clinically suspected CAD at a tertiary care hospital were recruited for the study. The presence and absence of significant CAD was determined after a coronary angiogram. Clinical history, and anthropometric and biochemical parameters were analyzed. Insulin resistance was determined by the Homeostasis Model Assessment. Multiple logistic regressions were done to find out the factors associated for a favorable CAD profile. Results: The difference in HOMA-IR (2.37±0.69 VS 3.77±1.64, p<0.001) and urine microalbumin (24.15±32.16 VS 82.72±117.70, p=0.004) were found to be statistically significant among those who did not have CAD when compared to those who had CAD. The difference in lipid profile, HbA1C, fasting blood sugar, BMI, waist hip ratio, waist and hip circumference was not significant. The adjusted odds ratio for insulin resistance less than 2.5 (OR 9.09, 95% CI 1.91-41.83, p=0.005), females (OR 7.91, 95% CI 1.55-40.38, p=0.013) and microalbumin <20mg/l (OR 4.57, 95% CI 1.17-17.85, p=0.029) were independently associated with normal coronaries. The adjusted odds ratio for lipid profile, BMI, blood pressure and HbA1C were not significant. Conclusions: HOMA-IR less than 2.5, microalbuminuria less than 20mg/l and females are the factors appear to be associated with no apparent CAD.

Original languageEnglish
Article number146
JournalCardiovascular Diabetology
Volume14
Issue number1
DOIs
Publication statusPublished - 31-10-2015

Fingerprint

Type 2 Diabetes Mellitus
Case-Control Studies
Coronary Artery Disease
Insulin Resistance
Angiography
Odds Ratio
Lipids
Waist-Hip Ratio
Waist Circumference
Tertiary Healthcare
Tertiary Care Centers
Blood Glucose
Hip
Fasting
Homeostasis
Logistic Models
Urine
Blood Pressure
Therapeutics

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine

Cite this

@article{690abde92dcb4d329f7025a6ab2162fe,
title = "Factors associated with no apparent coronary artery disease in patients with type 2 diabetes mellitus for more than 10years of duration: A case control study",
abstract = "Background: Type 2 diabetes mellitus is an important risk factor in the development of coronary artery disease (CAD) and is often associated with severe disease. However, this risk is not uniform, some patients remain free of CAD even after many years of treatment for diabetes. The present study was aimed to identify the factors that are associated with a favorable CAD profile. Methods: A case-control study of 76 patients with type 2 diabetes mellitus who were on treatment for more than 10years duration and undergoing a coronary angiogram for the evaluation of clinically suspected CAD at a tertiary care hospital were recruited for the study. The presence and absence of significant CAD was determined after a coronary angiogram. Clinical history, and anthropometric and biochemical parameters were analyzed. Insulin resistance was determined by the Homeostasis Model Assessment. Multiple logistic regressions were done to find out the factors associated for a favorable CAD profile. Results: The difference in HOMA-IR (2.37±0.69 VS 3.77±1.64, p<0.001) and urine microalbumin (24.15±32.16 VS 82.72±117.70, p=0.004) were found to be statistically significant among those who did not have CAD when compared to those who had CAD. The difference in lipid profile, HbA1C, fasting blood sugar, BMI, waist hip ratio, waist and hip circumference was not significant. The adjusted odds ratio for insulin resistance less than 2.5 (OR 9.09, 95{\%} CI 1.91-41.83, p=0.005), females (OR 7.91, 95{\%} CI 1.55-40.38, p=0.013) and microalbumin <20mg/l (OR 4.57, 95{\%} CI 1.17-17.85, p=0.029) were independently associated with normal coronaries. The adjusted odds ratio for lipid profile, BMI, blood pressure and HbA1C were not significant. Conclusions: HOMA-IR less than 2.5, microalbuminuria less than 20mg/l and females are the factors appear to be associated with no apparent CAD.",
author = "Srinivasan, {Mukund P.} and Kamath, {Padmanabh K.} and Bhat, {Narayan M.} and Pai, {Narasimha D.} and Manjrekar, {Poornima A.} and Chakrapani Mahabala",
year = "2015",
month = "10",
day = "31",
doi = "10.1186/s12933-015-0307-z",
language = "English",
volume = "14",
journal = "Cardiovascular Diabetology",
issn = "1475-2840",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Factors associated with no apparent coronary artery disease in patients with type 2 diabetes mellitus for more than 10years of duration

T2 - A case control study

AU - Srinivasan, Mukund P.

AU - Kamath, Padmanabh K.

AU - Bhat, Narayan M.

AU - Pai, Narasimha D.

AU - Manjrekar, Poornima A.

AU - Mahabala, Chakrapani

PY - 2015/10/31

Y1 - 2015/10/31

N2 - Background: Type 2 diabetes mellitus is an important risk factor in the development of coronary artery disease (CAD) and is often associated with severe disease. However, this risk is not uniform, some patients remain free of CAD even after many years of treatment for diabetes. The present study was aimed to identify the factors that are associated with a favorable CAD profile. Methods: A case-control study of 76 patients with type 2 diabetes mellitus who were on treatment for more than 10years duration and undergoing a coronary angiogram for the evaluation of clinically suspected CAD at a tertiary care hospital were recruited for the study. The presence and absence of significant CAD was determined after a coronary angiogram. Clinical history, and anthropometric and biochemical parameters were analyzed. Insulin resistance was determined by the Homeostasis Model Assessment. Multiple logistic regressions were done to find out the factors associated for a favorable CAD profile. Results: The difference in HOMA-IR (2.37±0.69 VS 3.77±1.64, p<0.001) and urine microalbumin (24.15±32.16 VS 82.72±117.70, p=0.004) were found to be statistically significant among those who did not have CAD when compared to those who had CAD. The difference in lipid profile, HbA1C, fasting blood sugar, BMI, waist hip ratio, waist and hip circumference was not significant. The adjusted odds ratio for insulin resistance less than 2.5 (OR 9.09, 95% CI 1.91-41.83, p=0.005), females (OR 7.91, 95% CI 1.55-40.38, p=0.013) and microalbumin <20mg/l (OR 4.57, 95% CI 1.17-17.85, p=0.029) were independently associated with normal coronaries. The adjusted odds ratio for lipid profile, BMI, blood pressure and HbA1C were not significant. Conclusions: HOMA-IR less than 2.5, microalbuminuria less than 20mg/l and females are the factors appear to be associated with no apparent CAD.

AB - Background: Type 2 diabetes mellitus is an important risk factor in the development of coronary artery disease (CAD) and is often associated with severe disease. However, this risk is not uniform, some patients remain free of CAD even after many years of treatment for diabetes. The present study was aimed to identify the factors that are associated with a favorable CAD profile. Methods: A case-control study of 76 patients with type 2 diabetes mellitus who were on treatment for more than 10years duration and undergoing a coronary angiogram for the evaluation of clinically suspected CAD at a tertiary care hospital were recruited for the study. The presence and absence of significant CAD was determined after a coronary angiogram. Clinical history, and anthropometric and biochemical parameters were analyzed. Insulin resistance was determined by the Homeostasis Model Assessment. Multiple logistic regressions were done to find out the factors associated for a favorable CAD profile. Results: The difference in HOMA-IR (2.37±0.69 VS 3.77±1.64, p<0.001) and urine microalbumin (24.15±32.16 VS 82.72±117.70, p=0.004) were found to be statistically significant among those who did not have CAD when compared to those who had CAD. The difference in lipid profile, HbA1C, fasting blood sugar, BMI, waist hip ratio, waist and hip circumference was not significant. The adjusted odds ratio for insulin resistance less than 2.5 (OR 9.09, 95% CI 1.91-41.83, p=0.005), females (OR 7.91, 95% CI 1.55-40.38, p=0.013) and microalbumin <20mg/l (OR 4.57, 95% CI 1.17-17.85, p=0.029) were independently associated with normal coronaries. The adjusted odds ratio for lipid profile, BMI, blood pressure and HbA1C were not significant. Conclusions: HOMA-IR less than 2.5, microalbuminuria less than 20mg/l and females are the factors appear to be associated with no apparent CAD.

UR - http://www.scopus.com/inward/record.url?scp=84946493955&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84946493955&partnerID=8YFLogxK

U2 - 10.1186/s12933-015-0307-z

DO - 10.1186/s12933-015-0307-z

M3 - Article

C2 - 26521236

AN - SCOPUS:84946493955

VL - 14

JO - Cardiovascular Diabetology

JF - Cardiovascular Diabetology

SN - 1475-2840

IS - 1

M1 - 146

ER -