Objective: To assess fear potentiated poststartle activity in adult rats administered clomipramine during neonatal period ('CLI rats'). Methods: Rat pups were treated twice daily from postnatal day 5 to 21 with clomipramine (15 mg/kg, S.C). At three months of age CLI rats were given twenty trials per day, for two days. In each trial an unconditioned stimulus (US), namely footshock (0.8 mA) was presented during the last 0.5 sec of the 1.0 sec conditioned stimulus (CS), namely light. Twenty-four hours after the last conditioning trial, rats were presented with twenty alternated sequence of light-tone (98 dB) and tone-alone trials. Results: CLI rats showed an enhanced potentiated poststartle activity and increased activity in open field as compared to control rats. Conclusion: The present data suggest an increased expression of fear/anxiety in CLI rats.
|Number of pages||3|
|Journal||Indian Journal of Pharmacology|
|Publication status||Published - 01-06-1997|
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