Fecal carriage of extended-spectrum beta-lactamase-producing enterobacteriaceae in intensive care unit patients

Shalini Shenoy Mulki, Kavya Ramamurthy, Sevitha Bhat

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background and Aims: Increasing and indiscriminate use of antibiotics has led the bacteria to develop resistance to most of the antibiotics. Beta-lactamase production is the mechanism of resistance to beta-lactams. Extended-spectrum beta-lactamases (ESBLs) have been found in the members of Enterobacteriaceae such as Escherichia coli and Klebsiella spp. which are the common health-care-associated pathogens. The aim was to study the rate of fecal carriage of ESBL-producing Enterobacteriaceae in patients admitted to the Intensive Care Unit (ICU) of tertiary care hospital and follow them subsequently for the development of infections. Materials and Methods: A hospital-based descriptive study was conducted in the department of microbiology of a tertiary care hospital for a period of 2 months from June 2016 to August 2016. Rectal swabs were collected from the patients admitted to the ICU after a period of 48 h. The swab was inoculated onto a special selective media (ChromID ESBL media). The results were noted according to the color of the colony produced. These patients are followed for the development of infection and the ESBL-producing organisms. Results: A total of 60 rectal swabs were cultured, 39 (65%) showed a positive result. Out of which, 22 (56%) were ESBL-producing E. coli and 17 (43%) Klebsiella spp. Twenty-three (38%) of the total patients screened were infected with ESBL-producing organisms. Conclusion: The study revealed high rates of carriage of ESBL producers in patients admitted to the ICU.

Original languageEnglish
Pages (from-to)525-527
Number of pages3
JournalIndian Journal of Critical Care Medicine
Volume21
Issue number8
DOIs
Publication statusPublished - 01-08-2017

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Enterobacteriaceae
beta-Lactamases
Intensive Care Units
Klebsiella
Tertiary Healthcare
Tertiary Care Centers
beta-Lactam Resistance
Escherichia coli
Anti-Bacterial Agents
Microbiology
Infection
Color
Bacteria
Delivery of Health Care

All Science Journal Classification (ASJC) codes

  • Critical Care and Intensive Care Medicine

Cite this

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title = "Fecal carriage of extended-spectrum beta-lactamase-producing enterobacteriaceae in intensive care unit patients",
abstract = "Background and Aims: Increasing and indiscriminate use of antibiotics has led the bacteria to develop resistance to most of the antibiotics. Beta-lactamase production is the mechanism of resistance to beta-lactams. Extended-spectrum beta-lactamases (ESBLs) have been found in the members of Enterobacteriaceae such as Escherichia coli and Klebsiella spp. which are the common health-care-associated pathogens. The aim was to study the rate of fecal carriage of ESBL-producing Enterobacteriaceae in patients admitted to the Intensive Care Unit (ICU) of tertiary care hospital and follow them subsequently for the development of infections. Materials and Methods: A hospital-based descriptive study was conducted in the department of microbiology of a tertiary care hospital for a period of 2 months from June 2016 to August 2016. Rectal swabs were collected from the patients admitted to the ICU after a period of 48 h. The swab was inoculated onto a special selective media (ChromID ESBL media). The results were noted according to the color of the colony produced. These patients are followed for the development of infection and the ESBL-producing organisms. Results: A total of 60 rectal swabs were cultured, 39 (65{\%}) showed a positive result. Out of which, 22 (56{\%}) were ESBL-producing E. coli and 17 (43{\%}) Klebsiella spp. Twenty-three (38{\%}) of the total patients screened were infected with ESBL-producing organisms. Conclusion: The study revealed high rates of carriage of ESBL producers in patients admitted to the ICU.",
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Fecal carriage of extended-spectrum beta-lactamase-producing enterobacteriaceae in intensive care unit patients. / Mulki, Shalini Shenoy; Ramamurthy, Kavya; Bhat, Sevitha.

In: Indian Journal of Critical Care Medicine, Vol. 21, No. 8, 01.08.2017, p. 525-527.

Research output: Contribution to journalArticle

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N2 - Background and Aims: Increasing and indiscriminate use of antibiotics has led the bacteria to develop resistance to most of the antibiotics. Beta-lactamase production is the mechanism of resistance to beta-lactams. Extended-spectrum beta-lactamases (ESBLs) have been found in the members of Enterobacteriaceae such as Escherichia coli and Klebsiella spp. which are the common health-care-associated pathogens. The aim was to study the rate of fecal carriage of ESBL-producing Enterobacteriaceae in patients admitted to the Intensive Care Unit (ICU) of tertiary care hospital and follow them subsequently for the development of infections. Materials and Methods: A hospital-based descriptive study was conducted in the department of microbiology of a tertiary care hospital for a period of 2 months from June 2016 to August 2016. Rectal swabs were collected from the patients admitted to the ICU after a period of 48 h. The swab was inoculated onto a special selective media (ChromID ESBL media). The results were noted according to the color of the colony produced. These patients are followed for the development of infection and the ESBL-producing organisms. Results: A total of 60 rectal swabs were cultured, 39 (65%) showed a positive result. Out of which, 22 (56%) were ESBL-producing E. coli and 17 (43%) Klebsiella spp. Twenty-three (38%) of the total patients screened were infected with ESBL-producing organisms. Conclusion: The study revealed high rates of carriage of ESBL producers in patients admitted to the ICU.

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