Fertility preservation in men and prepubertal boys

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Managing the fertility potential has emerged as a major concern for young men who receive gonadotoxic therapy for various malignant and nonmalignant conditions. One of the major causes of non-accidental mortality worldwide is cancer. Over the past few decades, due to the development of reasonably effective cancer treatment regimens, survival rate among childhood cancer patients has increased. A recent estimate suggests that ~1 in 530 young adults between the ages of 20 and 39 years is a childhood cancer survivor. Unfortunately, the different cancer regimens like radiotherapy and/or chemotherapy employed to cure cancer also damage other healthy rapidly dividing cells such as the spermatogonial stem cells. Thus, cancer treatments become gonadotoxic and render patients to suffer subfertility or infertility. Infertility or subfertility due to cancer treatment may be reversible in some cases, whereas persistent infertility may occur in 50-95 % of malignancies. Hence, maintaining reproductive health or the ability to father a normal biological child post-cancer treatment becomes of paramount concern in cancer survivors. To tackle these issues the area of fertility preservation has emerged as an option to maintain reproductive potential to all those who receive gonadotoxic treatments.

Original languageEnglish
Title of host publicationMale Infertility
Subtitle of host publicationA Clinical Approach
PublisherSpringer India
Pages221-230
Number of pages10
ISBN (Electronic)9788132236047
ISBN (Print)9788132236023
DOIs
Publication statusPublished - 01-01-2016

Fingerprint

Fertility Preservation
Infertility
Neoplasms
Survivors
Therapeutics
Aptitude
Reproductive Health
Fathers
Fertility
Young Adult
Radiotherapy
Stem Cells
Survival Rate

All Science Journal Classification (ASJC) codes

  • Health Professions(all)
  • Medicine(all)

Cite this

Uppangala, Shubhashree ; Kalthur, Guruprasad ; Adiga, Satish Kumar. / Fertility preservation in men and prepubertal boys. Male Infertility: A Clinical Approach. Springer India, 2016. pp. 221-230
@inbook{0eaafcb4e4a34da680919294fa4230f4,
title = "Fertility preservation in men and prepubertal boys",
abstract = "Managing the fertility potential has emerged as a major concern for young men who receive gonadotoxic therapy for various malignant and nonmalignant conditions. One of the major causes of non-accidental mortality worldwide is cancer. Over the past few decades, due to the development of reasonably effective cancer treatment regimens, survival rate among childhood cancer patients has increased. A recent estimate suggests that ~1 in 530 young adults between the ages of 20 and 39 years is a childhood cancer survivor. Unfortunately, the different cancer regimens like radiotherapy and/or chemotherapy employed to cure cancer also damage other healthy rapidly dividing cells such as the spermatogonial stem cells. Thus, cancer treatments become gonadotoxic and render patients to suffer subfertility or infertility. Infertility or subfertility due to cancer treatment may be reversible in some cases, whereas persistent infertility may occur in 50-95 {\%} of malignancies. Hence, maintaining reproductive health or the ability to father a normal biological child post-cancer treatment becomes of paramount concern in cancer survivors. To tackle these issues the area of fertility preservation has emerged as an option to maintain reproductive potential to all those who receive gonadotoxic treatments.",
author = "Shubhashree Uppangala and Guruprasad Kalthur and Adiga, {Satish Kumar}",
year = "2016",
month = "1",
day = "1",
doi = "10.1007/978-81-322-3604-7_15",
language = "English",
isbn = "9788132236023",
pages = "221--230",
booktitle = "Male Infertility",
publisher = "Springer India",
address = "India",

}

Fertility preservation in men and prepubertal boys. / Uppangala, Shubhashree; Kalthur, Guruprasad; Adiga, Satish Kumar.

Male Infertility: A Clinical Approach. Springer India, 2016. p. 221-230.

Research output: Chapter in Book/Report/Conference proceedingChapter

TY - CHAP

T1 - Fertility preservation in men and prepubertal boys

AU - Uppangala, Shubhashree

AU - Kalthur, Guruprasad

AU - Adiga, Satish Kumar

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Managing the fertility potential has emerged as a major concern for young men who receive gonadotoxic therapy for various malignant and nonmalignant conditions. One of the major causes of non-accidental mortality worldwide is cancer. Over the past few decades, due to the development of reasonably effective cancer treatment regimens, survival rate among childhood cancer patients has increased. A recent estimate suggests that ~1 in 530 young adults between the ages of 20 and 39 years is a childhood cancer survivor. Unfortunately, the different cancer regimens like radiotherapy and/or chemotherapy employed to cure cancer also damage other healthy rapidly dividing cells such as the spermatogonial stem cells. Thus, cancer treatments become gonadotoxic and render patients to suffer subfertility or infertility. Infertility or subfertility due to cancer treatment may be reversible in some cases, whereas persistent infertility may occur in 50-95 % of malignancies. Hence, maintaining reproductive health or the ability to father a normal biological child post-cancer treatment becomes of paramount concern in cancer survivors. To tackle these issues the area of fertility preservation has emerged as an option to maintain reproductive potential to all those who receive gonadotoxic treatments.

AB - Managing the fertility potential has emerged as a major concern for young men who receive gonadotoxic therapy for various malignant and nonmalignant conditions. One of the major causes of non-accidental mortality worldwide is cancer. Over the past few decades, due to the development of reasonably effective cancer treatment regimens, survival rate among childhood cancer patients has increased. A recent estimate suggests that ~1 in 530 young adults between the ages of 20 and 39 years is a childhood cancer survivor. Unfortunately, the different cancer regimens like radiotherapy and/or chemotherapy employed to cure cancer also damage other healthy rapidly dividing cells such as the spermatogonial stem cells. Thus, cancer treatments become gonadotoxic and render patients to suffer subfertility or infertility. Infertility or subfertility due to cancer treatment may be reversible in some cases, whereas persistent infertility may occur in 50-95 % of malignancies. Hence, maintaining reproductive health or the ability to father a normal biological child post-cancer treatment becomes of paramount concern in cancer survivors. To tackle these issues the area of fertility preservation has emerged as an option to maintain reproductive potential to all those who receive gonadotoxic treatments.

UR - http://www.scopus.com/inward/record.url?scp=85018590516&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85018590516&partnerID=8YFLogxK

U2 - 10.1007/978-81-322-3604-7_15

DO - 10.1007/978-81-322-3604-7_15

M3 - Chapter

AN - SCOPUS:85018590516

SN - 9788132236023

SP - 221

EP - 230

BT - Male Infertility

PB - Springer India

ER -