Follicular thyroid carcinoma in a patient with myasthenia gravis and thymoma: A rare association

H. Ni, A. Htet

Research output: Contribution to journalArticle

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Abstract

Myasthenia gravis (MG) is an autoantibody-mediated disorder affecting the neuromuscular junction causing characteristic fatigable muscle weakness. Though it can be associated with tumours of the thymus as well as thyroid disorders, it is rare for both to coexist. The exact prevalence of thyroid carcinoma in MG with thymoma is not known but only about a dozen cases have been reported in the literature. We report a case of a 38-year-old Myanmar lady who presented with weakness and breathlessness due to MG with neck swelling. On examination, she had fatigable proximal muscle weakness and thyroid enlargement with no obvious features of hyperthyroidism. Mediastinal widening and an enlarged thyroid gland were noted on her chest X-ray and chest CT. A subtotal thyroidectomy and thymectomy were done. The histology showed follicular carcinoma of the thyroid and benign thymoma. The majority of the reported cases of thyroid carcinoma in association with MG were papillary carcinoma. Follicular carcinoma thyroid associated with MG has not yet been reported in the literature.

Original languageEnglish
Article number274
Journalecancermedicalscience
Volume6
Issue number1
DOIs
Publication statusPublished - 18-10-2012
Externally publishedYes

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Follicular Adenocarcinoma
Thymoma
Myasthenia Gravis
Thyroid Gland
Muscle Weakness
Thyroid Neoplasms
Thorax
Neuromuscular Junction Diseases
Myanmar
Thymus Neoplasms
Thymectomy
X Ray Computed Tomography
Papillary Carcinoma
Thyroidectomy
Hyperthyroidism
Dyspnea
Autoantibodies
Histology
Neck

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

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abstract = "Myasthenia gravis (MG) is an autoantibody-mediated disorder affecting the neuromuscular junction causing characteristic fatigable muscle weakness. Though it can be associated with tumours of the thymus as well as thyroid disorders, it is rare for both to coexist. The exact prevalence of thyroid carcinoma in MG with thymoma is not known but only about a dozen cases have been reported in the literature. We report a case of a 38-year-old Myanmar lady who presented with weakness and breathlessness due to MG with neck swelling. On examination, she had fatigable proximal muscle weakness and thyroid enlargement with no obvious features of hyperthyroidism. Mediastinal widening and an enlarged thyroid gland were noted on her chest X-ray and chest CT. A subtotal thyroidectomy and thymectomy were done. The histology showed follicular carcinoma of the thyroid and benign thymoma. The majority of the reported cases of thyroid carcinoma in association with MG were papillary carcinoma. Follicular carcinoma thyroid associated with MG has not yet been reported in the literature.",
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Follicular thyroid carcinoma in a patient with myasthenia gravis and thymoma : A rare association. / Ni, H.; Htet, A.

In: ecancermedicalscience, Vol. 6, No. 1, 274, 18.10.2012.

Research output: Contribution to journalArticle

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