Formation of substituted propanenitrile during biginelli type reaction of tosyloxy benzaldehyde with malononitrile: Synthesis and crystal structure determination

Shubhalaxmi, C. S. Chidan Kumar, Hoong Kun Fun, K. Subrahmanya Bhat

Research output: Contribution to journalArticle


Reaction of active methylene compound with an aldehyde and thiourea under Biginelli conditions reported to yield dihydropyrimidine derivatives in good yield. Herein we report a special case wherein the isolated product was propanenitrile derivative resulting from Knoevenagel condensation of malononitrile with the aldehyde. The structure of the product was confirmed by single crystal X-ray diffraction studies.

Original languageEnglish
Pages (from-to)1228-1233
Number of pages6
JournalResearch Journal of Pharmaceutical, Biological and Chemical Sciences
Issue number3
Publication statusPublished - 01-01-2015


All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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