Reaction of active methylene compound with an aldehyde and thiourea under Biginelli conditions reported to yield dihydropyrimidine derivatives in good yield. Herein we report a special case wherein the isolated product was propanenitrile derivative resulting from Knoevenagel condensation of malononitrile with the aldehyde. The structure of the product was confirmed by single crystal X-ray diffraction studies.
|Number of pages||6|
|Journal||Research Journal of Pharmaceutical, Biological and Chemical Sciences|
|Publication status||Published - 01-01-2015|
All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)