Formation of substituted propanenitrile during biginelli type reaction of tosyloxy benzaldehyde with malononitrile

Synthesis and crystal structure determination

Shubhalaxmi, C. S. Chidan Kumar, Hoong Kun Fun, K. Subrahmanya Bhat

Research output: Contribution to journalArticle

Abstract

Reaction of active methylene compound with an aldehyde and thiourea under Biginelli conditions reported to yield dihydropyrimidine derivatives in good yield. Herein we report a special case wherein the isolated product was propanenitrile derivative resulting from Knoevenagel condensation of malononitrile with the aldehyde. The structure of the product was confirmed by single crystal X-ray diffraction studies.

Original languageEnglish
Pages (from-to)1228-1233
Number of pages6
JournalResearch Journal of Pharmaceutical, Biological and Chemical Sciences
Volume6
Issue number3
Publication statusPublished - 01-01-2015

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Aldehydes
Crystal structure
Derivatives
Thiourea
X-Ray Diffraction
Condensation
Single crystals
X ray diffraction
dicyanmethane
benzaldehyde

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

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abstract = "Reaction of active methylene compound with an aldehyde and thiourea under Biginelli conditions reported to yield dihydropyrimidine derivatives in good yield. Herein we report a special case wherein the isolated product was propanenitrile derivative resulting from Knoevenagel condensation of malononitrile with the aldehyde. The structure of the product was confirmed by single crystal X-ray diffraction studies.",
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AU - Fun, Hoong Kun

AU - Subrahmanya Bhat, K.

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