Formulation and evaluation of methotrexate niosomes

N. Udupa, K. S. Chandraprakash, P. Umadevi, G. K. Pillai

Research output: Contribution to journalArticle

23 Citations (Scopus)


Methotrexate was encapsulated in niosomes prepared using Tweens and Spans. The size distribution, entrapment efficiency, pharmacokinetics and effect on tumour remission of mice transplanted with S-180 Sarcoma were evaluated. Niosomes prepared with Span 60 gave promising results.

Original languageEnglish
Pages (from-to)1331-1342
Number of pages12
JournalDrug Development and Industrial Pharmacy
Issue number11
Publication statusPublished - 01-01-1993


All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry

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