Formulation and evaluation of oral sustained release of Diltiazem Hydrochloride using rosin as matrix forming material

S. Lakshmana Prabu, A. Shirwaikar, A. Shirwaikar, G. Ravikumar, A. Kumar, A. Jacob

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Rosin, a natural resin, was used as a hydrophobic matrix material for the controlled release, using diltiazem HCl as model drug. Matrix tablets were prepared by direct compression method using rosin as matrix forming material in different proportions and with different diluent combinations. The tablets prepared were flat faced, retained their shape throughout. The method of preparation of matrix system and its concentration were found to have pronounced effect on the release of diltiazem HCl. The release was found to follow both the first order kinetics and fickian diffusion. The drug delivery was analyzed using the paddle method according to USP XXIII. All the studies were done in phosphate buffer pH 7.4. The matrix tablets were evaluated for its thickness, hardness, friability, weight variation, drug content and invitro release studies. The results suggest that the rosin is useful in developing sustained release matrix tablets, prolong release of water soluble drug for up to 24h. Rosin thus promises considerable utility in the development of oral sustained release drug delivery systems.
Original languageEnglish
Pages (from-to)32-42
Number of pages11
JournalArs Pharmaceutica
Volume50
Issue number1
Publication statusPublished - 2009
Externally publishedYes

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Diltiazem
Tablets
Pharmaceutical Preparations
Hardness
Drug Delivery Systems
Buffers
Phosphates
Weights and Measures
rosin
Evaluation
Water
Drugs

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Lakshmana Prabu, S., Shirwaikar, A., Shirwaikar, A., Ravikumar, G., Kumar, A., & Jacob, A. (2009). Formulation and evaluation of oral sustained release of Diltiazem Hydrochloride using rosin as matrix forming material. Ars Pharmaceutica, 50(1), 32-42.
Lakshmana Prabu, S. ; Shirwaikar, A. ; Shirwaikar, A. ; Ravikumar, G. ; Kumar, A. ; Jacob, A. / Formulation and evaluation of oral sustained release of Diltiazem Hydrochloride using rosin as matrix forming material. In: Ars Pharmaceutica. 2009 ; Vol. 50, No. 1. pp. 32-42.
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abstract = "Rosin, a natural resin, was used as a hydrophobic matrix material for the controlled release, using diltiazem HCl as model drug. Matrix tablets were prepared by direct compression method using rosin as matrix forming material in different proportions and with different diluent combinations. The tablets prepared were flat faced, retained their shape throughout. The method of preparation of matrix system and its concentration were found to have pronounced effect on the release of diltiazem HCl. The release was found to follow both the first order kinetics and fickian diffusion. The drug delivery was analyzed using the paddle method according to USP XXIII. All the studies were done in phosphate buffer pH 7.4. The matrix tablets were evaluated for its thickness, hardness, friability, weight variation, drug content and invitro release studies. The results suggest that the rosin is useful in developing sustained release matrix tablets, prolong release of water soluble drug for up to 24h. Rosin thus promises considerable utility in the development of oral sustained release drug delivery systems.",
author = "{Lakshmana Prabu}, S. and A. Shirwaikar and A. Shirwaikar and G. Ravikumar and A. Kumar and A. Jacob",
note = "Cited By :25 Export Date: 10 November 2017 Correspondence Address: Lakshmana Prabu, S.; Dept. of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal University, Madhav Nagar, Manipal - 576 104, Karnataka, India; email: slaxmanvel@gmail.com Chemicals/CAS: diltiazem, 33286-22-5, 42399-41-7; rosin, 8050-09-7 References: Lordi, N.G., Sustained release dosage forms (1986) The Theory and Practice of Industrial Pharmacy, 3rd Ed., pp. 430-456. , Lachman L, Liberman HA, Joseph LK Varghese Publishing House, Bombay; Thomas, W.Y.L., Joseph, R.R., Controlled release drug delivery systems (2000) Remington: The Science and Practice of Pharmacy, pp. 903-906. , Gennaro AR Lippincott Williams and Wilkins, Philadelphia; Baveja, S.K., Ranga Rao, K.V., Arora, J., Examination of natural gums and mucilages as sustaining materials in tablet dosage forms - Part II (1989) Indian Journal of Pharmaceutical Sciences, 51 (4), pp. 115-118; Kakkar, A.P., Singh, M., Medirrata, A., Formulation optimization of diltiazem Hydrochloride matrix tablets containing modified isphagula husk using factorial design (1997) Drug Dev Ind Pharm, 23 (11), pp. 1055-1061; Sheorey, D.S., Dorle, A.K., Effect of solvents on the characteristics of rosin walled microcapsules prepared by a solvent evaporation technique (1991) J Microencapsul, 8 (1), pp. 71-78; Sheorey, D.S., Dorle, A.K., Rosin coacervate microcapsules: Effect of solvent on phase separation of rosin (1993) J Microencapsul, 10 (2), pp. 209-214; Shirwaikar, A.A., Reddy, N., Rosin, a polymer for micro encapsulation of Diltiazem Hydrochloride for sustained release by emulsion solvent evaporation technique (2000) Ind J Pharm Sci, 62 (4), pp. 308-310; Pathak, Y.V., Dorle, A.K., Rosin and rosin derivatives as hydrophobic matrix materials for controlled release of drugs (1990) Drug Dev Ind Pharm, 6 (3), pp. 223-227; Ramani, C.C., Puranik, P.K., Dorle, A.K., Study of maleoabietic acid as matrix forming material (1996) Int J Pharm, 1, pp. 344-352; Satturwar, P.M., Fulzele, S.V., Mandaogade, P.M., Mundhada, D.R., Gogte, B.B., Dorle, A.K., Evaluation of new rosin derivative for pharmaceutical coating (2004) Int J Pharm, 270 (1-2), pp. 27-36; Fulzele, S.V., Satturwar, P.M., Dorle, A.K., Polymerized rosin: Novel film forming polymer for drug delivery (2002) International Journal of Pharmaceutics, 249 (1-2), pp. 175-184. , DOI 10.1016/S0378-5173(02)00529-X, PII S037851730200529X; Satturwar, P.M., Fulzele, S.V., Dorle, A.K., Evaluation of polymerized rosin for the formulationand evelopment of transdermal drug delivery system. A technical note (2005) AAPSPharmSciTech, 6 (4). , article 81; Fulzele, S.V., Satturwar, P.M., Dorle, A.K., Study of the biodegradation and in vivo bio compatibility of novel biomaterials (2003) Eur J Pharm Sci, 20 (1), pp. 53-61; Satturwar, P.M., Fulzele, S.V., Dorle, A.K., Biodegradation studies of rosin based polymer (2003) Drug Dev Ind Pharm, 29 (6), pp. 669-677; Chaffman, M., Brogden, R.N., Diltiazem. a Review of its pharmacological properties and therapeutic efficacy (1985) Drugs, 29 (5), pp. 387-454; Kim, H., Fassihi, R., New ternary polymeric matrix system for control drug delivery of highly soluble drugs (1997) Pharm Res, 14, pp. 1415-1421; Logannathan, V., Senthil Kumar, K., Siva Prasada Reddy, M.V., Sreekanth, N., Senthil Kumar, B., Studies on preformulation compatibility between lomefloxacin and tablet excipients through DSC and X-ray diffraction analysis (2003) Int Journal of Pharmaceutical Excipients, pp. 38-49. , April-June; (1996) British Pharmacopoeia Addendum 1996, p. 658. , Bristish Pharmacopoeia Commission London, UK: British Pharmacopoeia Commission; Banker, G.S., Anderson, (1987) The Theory and Practice of Industrial Pharmacy, 3rd Ed., p. 383. , Lachman L, Liberman HA, Kanig JL. Varghese publishing house, Mumbai",
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}

Lakshmana Prabu, S, Shirwaikar, A, Shirwaikar, A, Ravikumar, G, Kumar, A & Jacob, A 2009, 'Formulation and evaluation of oral sustained release of Diltiazem Hydrochloride using rosin as matrix forming material', Ars Pharmaceutica, vol. 50, no. 1, pp. 32-42.

Formulation and evaluation of oral sustained release of Diltiazem Hydrochloride using rosin as matrix forming material. / Lakshmana Prabu, S.; Shirwaikar, A.; Shirwaikar, A.; Ravikumar, G.; Kumar, A.; Jacob, A.

In: Ars Pharmaceutica, Vol. 50, No. 1, 2009, p. 32-42.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Formulation and evaluation of oral sustained release of Diltiazem Hydrochloride using rosin as matrix forming material

AU - Lakshmana Prabu, S.

AU - Shirwaikar, A.

AU - Shirwaikar, A.

AU - Ravikumar, G.

AU - Kumar, A.

AU - Jacob, A.

N1 - Cited By :25 Export Date: 10 November 2017 Correspondence Address: Lakshmana Prabu, S.; Dept. of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal University, Madhav Nagar, Manipal - 576 104, Karnataka, India; email: slaxmanvel@gmail.com Chemicals/CAS: diltiazem, 33286-22-5, 42399-41-7; rosin, 8050-09-7 References: Lordi, N.G., Sustained release dosage forms (1986) The Theory and Practice of Industrial Pharmacy, 3rd Ed., pp. 430-456. , Lachman L, Liberman HA, Joseph LK Varghese Publishing House, Bombay; Thomas, W.Y.L., Joseph, R.R., Controlled release drug delivery systems (2000) Remington: The Science and Practice of Pharmacy, pp. 903-906. , Gennaro AR Lippincott Williams and Wilkins, Philadelphia; Baveja, S.K., Ranga Rao, K.V., Arora, J., Examination of natural gums and mucilages as sustaining materials in tablet dosage forms - Part II (1989) Indian Journal of Pharmaceutical Sciences, 51 (4), pp. 115-118; Kakkar, A.P., Singh, M., Medirrata, A., Formulation optimization of diltiazem Hydrochloride matrix tablets containing modified isphagula husk using factorial design (1997) Drug Dev Ind Pharm, 23 (11), pp. 1055-1061; Sheorey, D.S., Dorle, A.K., Effect of solvents on the characteristics of rosin walled microcapsules prepared by a solvent evaporation technique (1991) J Microencapsul, 8 (1), pp. 71-78; Sheorey, D.S., Dorle, A.K., Rosin coacervate microcapsules: Effect of solvent on phase separation of rosin (1993) J Microencapsul, 10 (2), pp. 209-214; Shirwaikar, A.A., Reddy, N., Rosin, a polymer for micro encapsulation of Diltiazem Hydrochloride for sustained release by emulsion solvent evaporation technique (2000) Ind J Pharm Sci, 62 (4), pp. 308-310; Pathak, Y.V., Dorle, A.K., Rosin and rosin derivatives as hydrophobic matrix materials for controlled release of drugs (1990) Drug Dev Ind Pharm, 6 (3), pp. 223-227; Ramani, C.C., Puranik, P.K., Dorle, A.K., Study of maleoabietic acid as matrix forming material (1996) Int J Pharm, 1, pp. 344-352; Satturwar, P.M., Fulzele, S.V., Mandaogade, P.M., Mundhada, D.R., Gogte, B.B., Dorle, A.K., Evaluation of new rosin derivative for pharmaceutical coating (2004) Int J Pharm, 270 (1-2), pp. 27-36; Fulzele, S.V., Satturwar, P.M., Dorle, A.K., Polymerized rosin: Novel film forming polymer for drug delivery (2002) International Journal of Pharmaceutics, 249 (1-2), pp. 175-184. , DOI 10.1016/S0378-5173(02)00529-X, PII S037851730200529X; Satturwar, P.M., Fulzele, S.V., Dorle, A.K., Evaluation of polymerized rosin for the formulationand evelopment of transdermal drug delivery system. A technical note (2005) AAPSPharmSciTech, 6 (4). , article 81; Fulzele, S.V., Satturwar, P.M., Dorle, A.K., Study of the biodegradation and in vivo bio compatibility of novel biomaterials (2003) Eur J Pharm Sci, 20 (1), pp. 53-61; Satturwar, P.M., Fulzele, S.V., Dorle, A.K., Biodegradation studies of rosin based polymer (2003) Drug Dev Ind Pharm, 29 (6), pp. 669-677; Chaffman, M., Brogden, R.N., Diltiazem. a Review of its pharmacological properties and therapeutic efficacy (1985) Drugs, 29 (5), pp. 387-454; Kim, H., Fassihi, R., New ternary polymeric matrix system for control drug delivery of highly soluble drugs (1997) Pharm Res, 14, pp. 1415-1421; Logannathan, V., Senthil Kumar, K., Siva Prasada Reddy, M.V., Sreekanth, N., Senthil Kumar, B., Studies on preformulation compatibility between lomefloxacin and tablet excipients through DSC and X-ray diffraction analysis (2003) Int Journal of Pharmaceutical Excipients, pp. 38-49. , April-June; (1996) British Pharmacopoeia Addendum 1996, p. 658. , Bristish Pharmacopoeia Commission London, UK: British Pharmacopoeia Commission; Banker, G.S., Anderson, (1987) The Theory and Practice of Industrial Pharmacy, 3rd Ed., p. 383. , Lachman L, Liberman HA, Kanig JL. Varghese publishing house, Mumbai

PY - 2009

Y1 - 2009

N2 - Rosin, a natural resin, was used as a hydrophobic matrix material for the controlled release, using diltiazem HCl as model drug. Matrix tablets were prepared by direct compression method using rosin as matrix forming material in different proportions and with different diluent combinations. The tablets prepared were flat faced, retained their shape throughout. The method of preparation of matrix system and its concentration were found to have pronounced effect on the release of diltiazem HCl. The release was found to follow both the first order kinetics and fickian diffusion. The drug delivery was analyzed using the paddle method according to USP XXIII. All the studies were done in phosphate buffer pH 7.4. The matrix tablets were evaluated for its thickness, hardness, friability, weight variation, drug content and invitro release studies. The results suggest that the rosin is useful in developing sustained release matrix tablets, prolong release of water soluble drug for up to 24h. Rosin thus promises considerable utility in the development of oral sustained release drug delivery systems.

AB - Rosin, a natural resin, was used as a hydrophobic matrix material for the controlled release, using diltiazem HCl as model drug. Matrix tablets were prepared by direct compression method using rosin as matrix forming material in different proportions and with different diluent combinations. The tablets prepared were flat faced, retained their shape throughout. The method of preparation of matrix system and its concentration were found to have pronounced effect on the release of diltiazem HCl. The release was found to follow both the first order kinetics and fickian diffusion. The drug delivery was analyzed using the paddle method according to USP XXIII. All the studies were done in phosphate buffer pH 7.4. The matrix tablets were evaluated for its thickness, hardness, friability, weight variation, drug content and invitro release studies. The results suggest that the rosin is useful in developing sustained release matrix tablets, prolong release of water soluble drug for up to 24h. Rosin thus promises considerable utility in the development of oral sustained release drug delivery systems.

M3 - Article

VL - 50

SP - 32

EP - 42

JO - Ars Pharmaceutica

JF - Ars Pharmaceutica

SN - 0004-2927

IS - 1

ER -

Lakshmana Prabu S, Shirwaikar A, Shirwaikar A, Ravikumar G, Kumar A, Jacob A. Formulation and evaluation of oral sustained release of Diltiazem Hydrochloride using rosin as matrix forming material. Ars Pharmaceutica. 2009;50(1):32-42.