Formulation and evaluation of sustained release dosage form of theophylline using a combined hydrophobic and hydrophilic matrix

B.S.N. Venkatesh, D. Hiremath

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Combination of aliphatic alcohol (cetyl alcohol) and partially hydrated methylcellulose was investigated as a sustained release matrix. Theophylline is used as a model drug for evaluating the matrix system. Cetyl alcohol and methyl cellulose were used in different proportions i.e., 2:1, 3:1, and 4:1 along with usual tablet additives, lactose and talc. The matrix component was varied from 20, 25 and 30% w/w of total tablet weight. The in vitro release data showed that 30% w/w total matrix component gave extended release of theophylline for more than 8 h. Analysis of drug release rate from the matrix system indicated that the drug was released by anomalous diffusion obeying first order rate kinetics.
Original languageUndefined/Unknown
Pages (from-to)33-36
Number of pages4
JournalIndian Journal of Pharmaceutical Sciences
Volume62
Issue number1
Publication statusPublished - 2000

Cite this

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abstract = "Combination of aliphatic alcohol (cetyl alcohol) and partially hydrated methylcellulose was investigated as a sustained release matrix. Theophylline is used as a model drug for evaluating the matrix system. Cetyl alcohol and methyl cellulose were used in different proportions i.e., 2:1, 3:1, and 4:1 along with usual tablet additives, lactose and talc. The matrix component was varied from 20, 25 and 30{\%} w/w of total tablet weight. The in vitro release data showed that 30{\%} w/w total matrix component gave extended release of theophylline for more than 8 h. Analysis of drug release rate from the matrix system indicated that the drug was released by anomalous diffusion obeying first order rate kinetics.",
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Formulation and evaluation of sustained release dosage form of theophylline using a combined hydrophobic and hydrophilic matrix. / Venkatesh, B.S.N.; Hiremath, D.

In: Indian Journal of Pharmaceutical Sciences, Vol. 62, No. 1, 2000, p. 33-36.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Formulation and evaluation of sustained release dosage form of theophylline using a combined hydrophobic and hydrophilic matrix

AU - Venkatesh, B.S.N.

AU - Hiremath, D.

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N2 - Combination of aliphatic alcohol (cetyl alcohol) and partially hydrated methylcellulose was investigated as a sustained release matrix. Theophylline is used as a model drug for evaluating the matrix system. Cetyl alcohol and methyl cellulose were used in different proportions i.e., 2:1, 3:1, and 4:1 along with usual tablet additives, lactose and talc. The matrix component was varied from 20, 25 and 30% w/w of total tablet weight. The in vitro release data showed that 30% w/w total matrix component gave extended release of theophylline for more than 8 h. Analysis of drug release rate from the matrix system indicated that the drug was released by anomalous diffusion obeying first order rate kinetics.

AB - Combination of aliphatic alcohol (cetyl alcohol) and partially hydrated methylcellulose was investigated as a sustained release matrix. Theophylline is used as a model drug for evaluating the matrix system. Cetyl alcohol and methyl cellulose were used in different proportions i.e., 2:1, 3:1, and 4:1 along with usual tablet additives, lactose and talc. The matrix component was varied from 20, 25 and 30% w/w of total tablet weight. The in vitro release data showed that 30% w/w total matrix component gave extended release of theophylline for more than 8 h. Analysis of drug release rate from the matrix system indicated that the drug was released by anomalous diffusion obeying first order rate kinetics.

M3 - Article

VL - 62

SP - 33

EP - 36

JO - Indian Journal of Pharmaceutical Sciences

JF - Indian Journal of Pharmaceutical Sciences

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