Formulation and evaluation of sustained release microspheres of rosin containing aceclofenac

S. Lakshmana Prabu, A. Shirwaikar, A. Shirwaikar, A. Kumar

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Aceclofenac was microencapsulated using rosin by o/w emulsion solvent evaporation technique. The effect of three formulation variables including the drug:polymer ratio, emulsifier (polyvinyl alcohol) concentration and organic solvent (dichloromethane) volume were examined. The prepared batches were characterized for microspheres particle size distribution, encapsulation efficiency and in vitro release behavior. The study reveals that drug:polymer ratio had a considerable effect on the entrapment efficiency, however particle size distribution of microspheres was more dependent on the volume of dichloromethane and polyvinyl alcohol concentration rather than on the drug: polymer ratio. Drug, polymer concentrations were varied to obtain optimum release profile for sustaining the action of the drug.
Original languageEnglish
Pages (from-to)1-12
Number of pages12
JournalArs Pharmaceutica
Volume50
Issue number2
Publication statusPublished - 2009

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Microspheres
Polymers
Polyvinyl Alcohol
Pharmaceutical Preparations
Methylene Chloride
Particle Size
Emulsions
rosin
aceclofenac
Drugs
Evaluation
Alcohol

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Lakshmana Prabu, S., Shirwaikar, A., Shirwaikar, A., & Kumar, A. (2009). Formulation and evaluation of sustained release microspheres of rosin containing aceclofenac. Ars Pharmaceutica, 50(2), 1-12.
Lakshmana Prabu, S. ; Shirwaikar, A. ; Shirwaikar, A. ; Kumar, A. / Formulation and evaluation of sustained release microspheres of rosin containing aceclofenac. In: Ars Pharmaceutica. 2009 ; Vol. 50, No. 2. pp. 1-12.
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abstract = "Aceclofenac was microencapsulated using rosin by o/w emulsion solvent evaporation technique. The effect of three formulation variables including the drug:polymer ratio, emulsifier (polyvinyl alcohol) concentration and organic solvent (dichloromethane) volume were examined. The prepared batches were characterized for microspheres particle size distribution, encapsulation efficiency and in vitro release behavior. The study reveals that drug:polymer ratio had a considerable effect on the entrapment efficiency, however particle size distribution of microspheres was more dependent on the volume of dichloromethane and polyvinyl alcohol concentration rather than on the drug: polymer ratio. Drug, polymer concentrations were varied to obtain optimum release profile for sustaining the action of the drug.",
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note = "Cited By :15 Export Date: 10 November 2017 Correspondence Address: Lakshmana Prabu, S.; Dept. of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal University, Madhav Nagar, Manipal - 576 104, Karnataka, India; email: slaxmanvel@gmail.com Chemicals/CAS: aceclofenac, 89796-99-6; dichloromethane, 75-09-2; polyvinyl alcohol, 37380-95-3, 9002-89-5; rosin, 8050-09-7 Manufacturers: Micro Labs, India; SD, India; yucca, India References: Jayakrishnan, A., Latha, M.S., Biodegradable polymeric microspheres as drug carriers (1997) Controlled and Novel drug delivery, pp. 236-255. , Jain NK, Editor, New Delhi: CBS publishers; Vyas, S.P., Khar, R.K., Proteins and peptides delivery considerations (2002) Controlled drug delivery concepts and advances, p. 549. , Vyas SP, Khar RK, Editor, 1 st ed. New Delhi: CBS publisher and Distributor; Fu, X., Ping, Q., Gao, Y., Effects of formulation factors on encapsulation efficiency and release behavior in vitro of huperzine A-PLGA microspheres (2005) J Microencap, 22 (7), pp. 705-714; Jalil, R., Nixon, J.R., Biodegradable poly(lactic acid) and poly(lactide-co-glycocide) microcapsules: Problems associated with preparative techniques and release properties (1990) J Microencap, 7, pp. 297-325; Kawaguchi, H., Functional polymer microspheres (2000) Prog Polym Sci, 25, pp. 1171-1210; Mueller, R.H., Jacobs, C., Kayser, O., Nanosuspensions as particulate drug formulations in therapy rationale for development and what we can expect for the future (2001) Adv Drug Deliv Review, 47, pp. 3-19; Edlund, U., Albertsson, A.C., Degradable polymer microspheres for controlled drug delivery (2002) Adv Polymeric Science, 157, pp. 67-112; Vasir, J.K., Tambwekar, K., Garg, G.S., Bioadhesive microspheres as a controlled drug delivery system (2003) Int J Pharm, 255, pp. 13-32; O'Donnell, P.B., McGinity, J.W., Preparation of microspheres by the solvent evaporatin technique (1997) Adv Drug Deliv Reviews, 28, pp. 25-42; Leelarasamee, N., Howard, S.A., Malanga, C.J., Ma, J.K.H., A method for the preparation of poly(lactic acid) microcapsules of controlled particle size and drug loading (1988) J Microencap, 52, pp. 147-157; Bain, D.F., Munday, D.L., Smith, A., Solvent influence on spray dried biodegradable microspheres (1999) J Microencap, 16, pp. 453-474; Jalil, R., Nixon, J.R., Microencapsulation using poly(l-lactic acid) I: Microcapsul properties affected by the preparative technique (1989) J Microencap, 6, pp. 473-484; Huang, Y.Y., Chung, T.W., Tzeng, T.W., Drug release from PLA/PEG microparticulates (1997) Int J Pharm, 156, pp. 9-15; Edlund, U., Albertsson, A.C., Novel drug delivery microspheres from poly(1,5-dioxepan-2-one-co-l-lactide) (1999) J Poly sci: Part A: Poly che, 37, pp. 1877-1884; Oh JE, Nam YS, Lee KH, Park TG. Conjugation of drug poly(d,l-lactic-co- glycolic acid) for controlled release from biodegradable microspheres. J Con Release 1999; 57: 269-280; Pistel KF, Bittner B, Koll H, Winter G, Kissel T. Biodegradable recombinant human erythropoietin loaded microspheres prepared from linear and start-branched block copolymers: influence of encapsulation technique and polymer composition on particle characteristics. J Con Release 1999; 59: 309-325; Bai, X.L., Yang, Y.Y., Chung, T.S., Ng, S., Heller, J., Effect of polymer compositions on the fabrication of poly(ortho-ester) microspheres for controlled release of protein (2001) J Appl Poly Sci, 80, pp. 1630-1642",
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Lakshmana Prabu, S, Shirwaikar, A, Shirwaikar, A & Kumar, A 2009, 'Formulation and evaluation of sustained release microspheres of rosin containing aceclofenac', Ars Pharmaceutica, vol. 50, no. 2, pp. 1-12.

Formulation and evaluation of sustained release microspheres of rosin containing aceclofenac. / Lakshmana Prabu, S.; Shirwaikar, A.; Shirwaikar, A.; Kumar, A.

In: Ars Pharmaceutica, Vol. 50, No. 2, 2009, p. 1-12.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Formulation and evaluation of sustained release microspheres of rosin containing aceclofenac

AU - Lakshmana Prabu, S.

AU - Shirwaikar, A.

AU - Shirwaikar, A.

AU - Kumar, A.

N1 - Cited By :15 Export Date: 10 November 2017 Correspondence Address: Lakshmana Prabu, S.; Dept. of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal University, Madhav Nagar, Manipal - 576 104, Karnataka, India; email: slaxmanvel@gmail.com Chemicals/CAS: aceclofenac, 89796-99-6; dichloromethane, 75-09-2; polyvinyl alcohol, 37380-95-3, 9002-89-5; rosin, 8050-09-7 Manufacturers: Micro Labs, India; SD, India; yucca, India References: Jayakrishnan, A., Latha, M.S., Biodegradable polymeric microspheres as drug carriers (1997) Controlled and Novel drug delivery, pp. 236-255. , Jain NK, Editor, New Delhi: CBS publishers; Vyas, S.P., Khar, R.K., Proteins and peptides delivery considerations (2002) Controlled drug delivery concepts and advances, p. 549. , Vyas SP, Khar RK, Editor, 1 st ed. New Delhi: CBS publisher and Distributor; Fu, X., Ping, Q., Gao, Y., Effects of formulation factors on encapsulation efficiency and release behavior in vitro of huperzine A-PLGA microspheres (2005) J Microencap, 22 (7), pp. 705-714; Jalil, R., Nixon, J.R., Biodegradable poly(lactic acid) and poly(lactide-co-glycocide) microcapsules: Problems associated with preparative techniques and release properties (1990) J Microencap, 7, pp. 297-325; Kawaguchi, H., Functional polymer microspheres (2000) Prog Polym Sci, 25, pp. 1171-1210; Mueller, R.H., Jacobs, C., Kayser, O., Nanosuspensions as particulate drug formulations in therapy rationale for development and what we can expect for the future (2001) Adv Drug Deliv Review, 47, pp. 3-19; Edlund, U., Albertsson, A.C., Degradable polymer microspheres for controlled drug delivery (2002) Adv Polymeric Science, 157, pp. 67-112; Vasir, J.K., Tambwekar, K., Garg, G.S., Bioadhesive microspheres as a controlled drug delivery system (2003) Int J Pharm, 255, pp. 13-32; O'Donnell, P.B., McGinity, J.W., Preparation of microspheres by the solvent evaporatin technique (1997) Adv Drug Deliv Reviews, 28, pp. 25-42; Leelarasamee, N., Howard, S.A., Malanga, C.J., Ma, J.K.H., A method for the preparation of poly(lactic acid) microcapsules of controlled particle size and drug loading (1988) J Microencap, 52, pp. 147-157; Bain, D.F., Munday, D.L., Smith, A., Solvent influence on spray dried biodegradable microspheres (1999) J Microencap, 16, pp. 453-474; Jalil, R., Nixon, J.R., Microencapsulation using poly(l-lactic acid) I: Microcapsul properties affected by the preparative technique (1989) J Microencap, 6, pp. 473-484; Huang, Y.Y., Chung, T.W., Tzeng, T.W., Drug release from PLA/PEG microparticulates (1997) Int J Pharm, 156, pp. 9-15; Edlund, U., Albertsson, A.C., Novel drug delivery microspheres from poly(1,5-dioxepan-2-one-co-l-lactide) (1999) J Poly sci: Part A: Poly che, 37, pp. 1877-1884; Oh JE, Nam YS, Lee KH, Park TG. Conjugation of drug poly(d,l-lactic-co- glycolic acid) for controlled release from biodegradable microspheres. J Con Release 1999; 57: 269-280; Pistel KF, Bittner B, Koll H, Winter G, Kissel T. Biodegradable recombinant human erythropoietin loaded microspheres prepared from linear and start-branched block copolymers: influence of encapsulation technique and polymer composition on particle characteristics. J Con Release 1999; 59: 309-325; Bai, X.L., Yang, Y.Y., Chung, T.S., Ng, S., Heller, J., Effect of polymer compositions on the fabrication of poly(ortho-ester) microspheres for controlled release of protein (2001) J Appl Poly Sci, 80, pp. 1630-1642

PY - 2009

Y1 - 2009

N2 - Aceclofenac was microencapsulated using rosin by o/w emulsion solvent evaporation technique. The effect of three formulation variables including the drug:polymer ratio, emulsifier (polyvinyl alcohol) concentration and organic solvent (dichloromethane) volume were examined. The prepared batches were characterized for microspheres particle size distribution, encapsulation efficiency and in vitro release behavior. The study reveals that drug:polymer ratio had a considerable effect on the entrapment efficiency, however particle size distribution of microspheres was more dependent on the volume of dichloromethane and polyvinyl alcohol concentration rather than on the drug: polymer ratio. Drug, polymer concentrations were varied to obtain optimum release profile for sustaining the action of the drug.

AB - Aceclofenac was microencapsulated using rosin by o/w emulsion solvent evaporation technique. The effect of three formulation variables including the drug:polymer ratio, emulsifier (polyvinyl alcohol) concentration and organic solvent (dichloromethane) volume were examined. The prepared batches were characterized for microspheres particle size distribution, encapsulation efficiency and in vitro release behavior. The study reveals that drug:polymer ratio had a considerable effect on the entrapment efficiency, however particle size distribution of microspheres was more dependent on the volume of dichloromethane and polyvinyl alcohol concentration rather than on the drug: polymer ratio. Drug, polymer concentrations were varied to obtain optimum release profile for sustaining the action of the drug.

M3 - Article

VL - 50

SP - 1

EP - 12

JO - Ars Pharmaceutica

JF - Ars Pharmaceutica

SN - 0004-2927

IS - 2

ER -

Lakshmana Prabu S, Shirwaikar A, Shirwaikar A, Kumar A. Formulation and evaluation of sustained release microspheres of rosin containing aceclofenac. Ars Pharmaceutica. 2009;50(2):1-12.