@article{fc08f532beee4523a8033930c87bbef0,
title = "Formulation and evaluation of sustained release tablets using an insoluble rosin matrix system",
abstract = "Rosin, a natural resin, was used as an insoluble matrix forming material for studying the release of diltiazem HCl, which was taken as a model drug.The granules prepared were free flowing with good compressibility.The tablets prepared were flat faced, which retained their shape throughout. The method of preparation of matrix system and its concentration were found to have a pronounced effect on the release of diltiazem HCl. Various physical parameters of the granules and the tablets were evaluated. The release mechanisms and the release rate kinetics of the tablets were examined using different release models.The release was found to follow both the first order kinetics and Fickian diffusion. Marked differences in the release rate of the drug from different formulations were observed when % cumulative release was plotted against time.The drug delivery was analyzed using the paddle method according to USP XXIII. All the studies were done in distilled water.",
author = "A.A. Shirwaikar and S. Jacob and V. Grover",
note = "Cited By :9 Export Date: 10 November 2017 CODEN: IJSID Correspondence Address: Shirwaikar, A. A.; Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, MAHE, Manipal- 576 104, India; email: arunshirwaikar@yahoo.co.in References: Baveja, S.R., Ranga, R.K.V., Arora, J., (1989) Int. J. Pharm, 51, p. 115; Bhalla, H.L., Piyush, C.R., (1991) Indian Drugs, 28, p. 519; Kakkar, A.P., Singh, M., Medirrata, A., (1997) Drug. Develop. Ind. Pharm, 23, p. 1055; Dabbagh, M.A.., Ford, J.L.,Rubinstein, M.H. and Hogan, J.E., Int. J. Pharm., 1996 ,140; Gupta, P.K., Robinson, J.R., (1992) Treatise on Controlled Drug Delivery: Fundamentals, Optimization, and Applications, p. 255. , Marcel Dekker, New York; Chaffman, M., Brogden, R.N., (1985) Drugs, 29, p. 387; Kim, H., Fassihi, R., (1997) Pharm. Res, 14, p. 1415; Joseph, R.R., Eds, C.S.L.C., (1995) Remington: The Science and Practice of Pharmacy, 2. , 19th Edn, Mack Publishing Company, Easton, Pennsylvania, 1665; U.S.Food and Drug Administration, Centre for Food Safety and Applied Nutrition, Agency Response Letter, GRAS Notice No.GRN 000108(21 CFR 172.615,178.38,172.315); Dorle, A.K., Satturwar, P.M., Fulzule, S.V., (2003) AAPS Pharm Sci. Tech, 4, p. 55; Ansel, H.C., Popovich, N.G. and Allen, L.V., Eds.,In ; Pharmaceutical Dosage Forms and Drug Delivery Systems,6th Edn., B.I. Waverly Pvt.Ltd, New Delhi 1995,213; (1987) The Theory and Practice of Industrial Pharmacy, p. 431. , Lachman, L, Liebermann, A.H. and Kanig, L. J, Eds, 3rd Edn, Varghese Publishing Company, Mumbai; Indian Pharmacoepoeia, II, Controller of Publications, Government of India, New Delhi, 1996,736; Desai, S.J., Singh, P., Simonelli, A.P., Higuchi, W.I., (1996) J. Pharm. Sci, 55, p. 1230; Singh, P., Desai, S.J., Simonelli, A.P., Higuchi, W.I., (1967) J. Pharm. Sci, 56, p. 1542; Sujja-areevath, J., Munday, D.L., Cox, P.J., Khan, K.A., (1996) Int. J. Pharm, 139, p. 53; Panchagnula, R., Sood, A., (1998) Int. J.Pharm, 175, p. 95; Higuchi, T., (1963) J. Pharm. Sci, 52, p. 1145; Peppas, N.A., (1985) Pharm. Acta Helv, 60, p. 110; Shirwaikar, A.A., Srinatha, A., (2004) Indian J. Pharm. Sci, 66 (4), pp. 433-437",
year = "2005",
language = "English",
volume = "67",
pages = "80--83",
journal = "Indian Journal of Pharmaceutical Sciences",
issn = "0250-474X",
publisher = "Medknow Publications and Media Pvt. Ltd",
number = "1",
}