Formulation and Evaluation of Topical Drug Delivery Systems containing Ciprofloxacin and Tinidazole

Different topical formulations containing ciprofloxacin and tinidazole in lanolin petrolatum base, emulsion (water washable) base and PEG (water soluble) base were prepared and evaluated for drug release in phosphate buffer (pH 6.0). Antimicrobial activity of these formulations were compared against marketed formulation containing 1% w/w silver sulfadiazine USP. It was found that release of ciprofloxacin and tinidazole from the PEG base was maximum through sigma membrane in phosphate buffer (pH 6.0) and also observed that the release of tinidazole was more than that of ciprofloxacin. The formulations exhibited significant antimicrobial activity both against aerobic and anaerobic bacteria compared to the marketed formulation.The antimicrobial activity of formulation containing PEG was found to be higher than other formulations.