Centchroman, a non-steroidal contraceptive was formulated as biodegradable microspheres using alginate, chitosan, albumin and poly (lactic-co-glycolic) acid polymers. They were evaluated for physico-chemical characteristics, in vitro release profile in phosphate buffered saline (pH 7.4) and stability on storage at different conditions. All the formulations exhibited a prolonged drug release with significant (P<0.05) increase in stability at specified conditions of storage. It was observed that PLGA microsphere was the best biodegradable carrier for Centchroman amongst the others studied.
|Number of pages||4|
|Journal||Indian Journal of Pharmaceutical Sciences|
|Publication status||Published - 01-1998|
All Science Journal Classification (ASJC) codes
- Pharmaceutical Science