Abstract
Centchroman, a non-steroidal contraceptive was formulated as biodegradable microspheres using alginate, chitosan, albumin and poly (lactic-co-glycolic) acid polymers. They were evaluated for physico-chemical characteristics, in vitro release profile in phosphate buffered saline (pH 7.4) and stability on storage at different conditions. All the formulations exhibited a prolonged drug release with significant (P<0.05) increase in stability at specified conditions of storage. It was observed that PLGA microsphere was the best biodegradable carrier for Centchroman amongst the others studied.
| Original language | English |
|---|---|
| Pages (from-to) | 41-44 |
| Number of pages | 4 |
| Journal | Indian Journal of Pharmaceutical Sciences |
| Volume | 60 |
| Issue number | 1 |
| Publication status | Published - 01-1998 |
All Science Journal Classification (ASJC) codes
- Pharmaceutical Science