Formulation and in vitro evaluation of centchroman-loaded biodegradable microspheres

B. D. Shenoy, D. Kini, N. Udupa

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Centchroman, a non-steroidal contraceptive was formulated as biodegradable microspheres using alginate, chitosan, albumin and poly (lactic-co-glycolic) acid polymers. They were evaluated for physico-chemical characteristics, in vitro release profile in phosphate buffered saline (pH 7.4) and stability on storage at different conditions. All the formulations exhibited a prolonged drug release with significant (P<0.05) increase in stability at specified conditions of storage. It was observed that PLGA microsphere was the best biodegradable carrier for Centchroman amongst the others studied.

Original languageEnglish
Pages (from-to)41-44
Number of pages4
JournalIndian Journal of Pharmaceutical Sciences
Volume60
Issue number1
Publication statusPublished - 01-1998

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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