Formulation and in vitro evaluation of centchroman-loaded biodegradable microspheres

B. D. Shenoy, D. Kini, N. Udupa

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Centchroman, a non-steroidal contraceptive was formulated as biodegradable microspheres using alginate, chitosan, albumin and poly (lactic-co-glycolic) acid polymers. They were evaluated for physico-chemical characteristics, in vitro release profile in phosphate buffered saline (pH 7.4) and stability on storage at different conditions. All the formulations exhibited a prolonged drug release with significant (P<0.05) increase in stability at specified conditions of storage. It was observed that PLGA microsphere was the best biodegradable carrier for Centchroman amongst the others studied.

Original languageEnglish
Pages (from-to)41-44
Number of pages4
JournalIndian Journal of Pharmaceutical Sciences
Volume60
Issue number1
Publication statusPublished - 01-1998

Fingerprint

Centchroman
Microspheres
Chitosan
Contraceptive Agents
Albumins
Polymers
Phosphates
In Vitro Techniques
polylactic acid-polyglycolic acid copolymer

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

@article{9ad565288c2546399094f0338f0a0507,
title = "Formulation and in vitro evaluation of centchroman-loaded biodegradable microspheres",
abstract = "Centchroman, a non-steroidal contraceptive was formulated as biodegradable microspheres using alginate, chitosan, albumin and poly (lactic-co-glycolic) acid polymers. They were evaluated for physico-chemical characteristics, in vitro release profile in phosphate buffered saline (pH 7.4) and stability on storage at different conditions. All the formulations exhibited a prolonged drug release with significant (P<0.05) increase in stability at specified conditions of storage. It was observed that PLGA microsphere was the best biodegradable carrier for Centchroman amongst the others studied.",
author = "Shenoy, {B. D.} and D. Kini and N. Udupa",
note = "cited By 2",
year = "1998",
month = "1",
language = "English",
volume = "60",
pages = "41--44",
journal = "Indian Journal of Pharmaceutical Sciences",
issn = "0250-474X",
publisher = "Medknow Publications and Media Pvt. Ltd",
number = "1",

}

Formulation and in vitro evaluation of centchroman-loaded biodegradable microspheres. / Shenoy, B. D.; Kini, D.; Udupa, N.

In: Indian Journal of Pharmaceutical Sciences, Vol. 60, No. 1, 01.1998, p. 41-44.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Formulation and in vitro evaluation of centchroman-loaded biodegradable microspheres

AU - Shenoy, B. D.

AU - Kini, D.

AU - Udupa, N.

N1 - cited By 2

PY - 1998/1

Y1 - 1998/1

N2 - Centchroman, a non-steroidal contraceptive was formulated as biodegradable microspheres using alginate, chitosan, albumin and poly (lactic-co-glycolic) acid polymers. They were evaluated for physico-chemical characteristics, in vitro release profile in phosphate buffered saline (pH 7.4) and stability on storage at different conditions. All the formulations exhibited a prolonged drug release with significant (P<0.05) increase in stability at specified conditions of storage. It was observed that PLGA microsphere was the best biodegradable carrier for Centchroman amongst the others studied.

AB - Centchroman, a non-steroidal contraceptive was formulated as biodegradable microspheres using alginate, chitosan, albumin and poly (lactic-co-glycolic) acid polymers. They were evaluated for physico-chemical characteristics, in vitro release profile in phosphate buffered saline (pH 7.4) and stability on storage at different conditions. All the formulations exhibited a prolonged drug release with significant (P<0.05) increase in stability at specified conditions of storage. It was observed that PLGA microsphere was the best biodegradable carrier for Centchroman amongst the others studied.

UR - http://www.scopus.com/inward/record.url?scp=0031843511&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031843511&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0031843511

VL - 60

SP - 41

EP - 44

JO - Indian Journal of Pharmaceutical Sciences

JF - Indian Journal of Pharmaceutical Sciences

SN - 0250-474X

IS - 1

ER -