Formulation development and evaluation of glyburide beads for controlled release

D. Lohithasu, I. N S Harsha, K. Krishna Swaroop, G. Madhu, S. Bhagyalakshmi, K. Lavanya

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Oral controlled drug delivery systems represent the most popular form of controlled drug delivery systems for the advantages of oral route of drug administration. In certain conditions conventional drug release pattern is not suitable like Diabetes mellitus, Asthma, cardiovascular diseases Arthritis, Peptic ulcer etc. this present study an attempt was made to formulate controlled release beads of Glyburide by using Sodium alginate, HPMC K100M, Carbopol 940 and Calcium Chloride(fused).Beads were successfully prepared by Ionotropic Gelation Method. The prepared beads evaluated for various parameters lke encapsulation efficacy, swelling index, Mean particle size, flow properties and in vitro release. The yields were varies from 88-93.8% and encapsulation efficacy is up to 91.2% which encourage the investigation. The in-vitro dissolution profile of optimized formulation batch i.e., F4 is resulted up 12 hours. The various parameters of model equation of beads containing Glyburide in vitro kinetic release were thoroughly investigated and it was seen that the statistically significant confined to Zero- order, Higuchi and Korsmeyer- Peppas model. To establish the release kinetic, Korsmeyer- Peppas model shows the prominent release characteristics.

Original languageEnglish
Pages (from-to)170-177
Number of pages8
JournalDer Pharmacia Lettre
Volume5
Issue number3
Publication statusPublished - 20-08-2013

Fingerprint

Glyburide
carbopol 940
Drug Delivery Systems
Calcium Chloride
Peptic Ulcer
Particle Size
Arthritis
Oral Administration
Diabetes Mellitus
Cardiovascular Diseases
Asthma
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

Lohithasu, D., Harsha, I. N. S., Krishna Swaroop, K., Madhu, G., Bhagyalakshmi, S., & Lavanya, K. (2013). Formulation development and evaluation of glyburide beads for controlled release. Der Pharmacia Lettre, 5(3), 170-177.
Lohithasu, D. ; Harsha, I. N S ; Krishna Swaroop, K. ; Madhu, G. ; Bhagyalakshmi, S. ; Lavanya, K. / Formulation development and evaluation of glyburide beads for controlled release. In: Der Pharmacia Lettre. 2013 ; Vol. 5, No. 3. pp. 170-177.
@article{8b99ba58c9d1497d8c443e290cda607b,
title = "Formulation development and evaluation of glyburide beads for controlled release",
abstract = "Oral controlled drug delivery systems represent the most popular form of controlled drug delivery systems for the advantages of oral route of drug administration. In certain conditions conventional drug release pattern is not suitable like Diabetes mellitus, Asthma, cardiovascular diseases Arthritis, Peptic ulcer etc. this present study an attempt was made to formulate controlled release beads of Glyburide by using Sodium alginate, HPMC K100M, Carbopol 940 and Calcium Chloride(fused).Beads were successfully prepared by Ionotropic Gelation Method. The prepared beads evaluated for various parameters lke encapsulation efficacy, swelling index, Mean particle size, flow properties and in vitro release. The yields were varies from 88-93.8{\%} and encapsulation efficacy is up to 91.2{\%} which encourage the investigation. The in-vitro dissolution profile of optimized formulation batch i.e., F4 is resulted up 12 hours. The various parameters of model equation of beads containing Glyburide in vitro kinetic release were thoroughly investigated and it was seen that the statistically significant confined to Zero- order, Higuchi and Korsmeyer- Peppas model. To establish the release kinetic, Korsmeyer- Peppas model shows the prominent release characteristics.",
author = "D. Lohithasu and Harsha, {I. N S} and {Krishna Swaroop}, K. and G. Madhu and S. Bhagyalakshmi and K. Lavanya",
year = "2013",
month = "8",
day = "20",
language = "English",
volume = "5",
pages = "170--177",
journal = "Der Pharmacia Lettre",
issn = "0975-5071",
publisher = "Scholars Research Library",
number = "3",

}

Lohithasu, D, Harsha, INS, Krishna Swaroop, K, Madhu, G, Bhagyalakshmi, S & Lavanya, K 2013, 'Formulation development and evaluation of glyburide beads for controlled release', Der Pharmacia Lettre, vol. 5, no. 3, pp. 170-177.

Formulation development and evaluation of glyburide beads for controlled release. / Lohithasu, D.; Harsha, I. N S; Krishna Swaroop, K.; Madhu, G.; Bhagyalakshmi, S.; Lavanya, K.

In: Der Pharmacia Lettre, Vol. 5, No. 3, 20.08.2013, p. 170-177.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Formulation development and evaluation of glyburide beads for controlled release

AU - Lohithasu, D.

AU - Harsha, I. N S

AU - Krishna Swaroop, K.

AU - Madhu, G.

AU - Bhagyalakshmi, S.

AU - Lavanya, K.

PY - 2013/8/20

Y1 - 2013/8/20

N2 - Oral controlled drug delivery systems represent the most popular form of controlled drug delivery systems for the advantages of oral route of drug administration. In certain conditions conventional drug release pattern is not suitable like Diabetes mellitus, Asthma, cardiovascular diseases Arthritis, Peptic ulcer etc. this present study an attempt was made to formulate controlled release beads of Glyburide by using Sodium alginate, HPMC K100M, Carbopol 940 and Calcium Chloride(fused).Beads were successfully prepared by Ionotropic Gelation Method. The prepared beads evaluated for various parameters lke encapsulation efficacy, swelling index, Mean particle size, flow properties and in vitro release. The yields were varies from 88-93.8% and encapsulation efficacy is up to 91.2% which encourage the investigation. The in-vitro dissolution profile of optimized formulation batch i.e., F4 is resulted up 12 hours. The various parameters of model equation of beads containing Glyburide in vitro kinetic release were thoroughly investigated and it was seen that the statistically significant confined to Zero- order, Higuchi and Korsmeyer- Peppas model. To establish the release kinetic, Korsmeyer- Peppas model shows the prominent release characteristics.

AB - Oral controlled drug delivery systems represent the most popular form of controlled drug delivery systems for the advantages of oral route of drug administration. In certain conditions conventional drug release pattern is not suitable like Diabetes mellitus, Asthma, cardiovascular diseases Arthritis, Peptic ulcer etc. this present study an attempt was made to formulate controlled release beads of Glyburide by using Sodium alginate, HPMC K100M, Carbopol 940 and Calcium Chloride(fused).Beads were successfully prepared by Ionotropic Gelation Method. The prepared beads evaluated for various parameters lke encapsulation efficacy, swelling index, Mean particle size, flow properties and in vitro release. The yields were varies from 88-93.8% and encapsulation efficacy is up to 91.2% which encourage the investigation. The in-vitro dissolution profile of optimized formulation batch i.e., F4 is resulted up 12 hours. The various parameters of model equation of beads containing Glyburide in vitro kinetic release were thoroughly investigated and it was seen that the statistically significant confined to Zero- order, Higuchi and Korsmeyer- Peppas model. To establish the release kinetic, Korsmeyer- Peppas model shows the prominent release characteristics.

UR - http://www.scopus.com/inward/record.url?scp=84881487862&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84881487862&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84881487862

VL - 5

SP - 170

EP - 177

JO - Der Pharmacia Lettre

JF - Der Pharmacia Lettre

SN - 0975-5071

IS - 3

ER -

Lohithasu D, Harsha INS, Krishna Swaroop K, Madhu G, Bhagyalakshmi S, Lavanya K. Formulation development and evaluation of glyburide beads for controlled release. Der Pharmacia Lettre. 2013 Aug 20;5(3):170-177.