Formulation, Release Characteristics and Evaluation of Nimesulide Suppositories

Mohammed Gulzar Ahmed, Venkatesh, G. Khaksa, N. Udupa, K. L.K. Paranjyothy

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4 Citations (Scopus)

Abstract

Suppositories of nimesulide were formulated using cocoa butter and different polyethylene glycol (PEG) bases. PEG base suppositories showed a better permeation of drug with faster dissolution rate in vitro than cocoa butter base suppositories. The results of in vivo antiinflammatory activity of nimesulide suppositories in Wistar rats showed that suppositories of cocoa butter base exhibited better antiinflammatory activity than PEG bases.

Original languageEnglish
Pages (from-to)196-199
Number of pages4
JournalIndian Journal of Pharmaceutical Sciences
Volume62
Issue number3
Publication statusPublished - 05-2000

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All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Cite this

Ahmed, M. G., Venkatesh, Khaksa, G., Udupa, N., & Paranjyothy, K. L. K. (2000). Formulation, Release Characteristics and Evaluation of Nimesulide Suppositories. Indian Journal of Pharmaceutical Sciences, 62(3), 196-199.