Free radical reactions and antioxidant activities of sesamol: Pulse radiolytic and biochemical studies

R. Joshi, M.S. Kumar, K. Satyamoorthy, M.K. Unnikrisnan, T. Mukherjee

Research output: Contribution to journalArticle

107 Citations (Scopus)

Abstract

Sesamol (from Sesamum indicum) is a dietary compound, which is soluble in aqueous as well as lipid phases. Free radical scavenging reactions of sesamol, 5-hydroxy-1,3-benzodioxole, have been studied using a nanosecond pulse radiolysis technique. Sesamol efficiently scavenges hydroxyl, one-electron oxidizing, organo-haloperoxyl, lipid peroxyl, and tryptophanyl radicals. Its antioxidant activity has also been evaluated with cyclic voltammetry. In biochemical studies, it has been found to inhibit lipid peroxidation, hydroxyl radical-induced deoxyribose degradation, and DNA cleavage. These antioxidant and free radical scavenging activities of sesamol have been reported in the paper. © 2005 American Chemical Society.
Original languageEnglish
Pages (from-to)2696-2703
Number of pages8
JournalJournal of Agricultural and Food Chemistry
Volume53
Issue number7
DOIs
Publication statusPublished - 2005

Fingerprint

Free radical reactions
Free Radicals
Antioxidants
antioxidant activity
Scavenging
Sesamum indicum
Lipids
Hydroxyl Radical
hydroxyl radicals
lipids
Pulse Radiolysis
Sesamum
Deoxyribose
lipid peroxidation
Radiolysis
DNA Cleavage
electrons
antioxidants
degradation
Lipid Peroxidation

Cite this

@article{7164c6b4313e4670bd7f1d231ad90ede,
title = "Free radical reactions and antioxidant activities of sesamol: Pulse radiolytic and biochemical studies",
abstract = "Sesamol (from Sesamum indicum) is a dietary compound, which is soluble in aqueous as well as lipid phases. Free radical scavenging reactions of sesamol, 5-hydroxy-1,3-benzodioxole, have been studied using a nanosecond pulse radiolysis technique. Sesamol efficiently scavenges hydroxyl, one-electron oxidizing, organo-haloperoxyl, lipid peroxyl, and tryptophanyl radicals. Its antioxidant activity has also been evaluated with cyclic voltammetry. In biochemical studies, it has been found to inhibit lipid peroxidation, hydroxyl radical-induced deoxyribose degradation, and DNA cleavage. These antioxidant and free radical scavenging activities of sesamol have been reported in the paper. {\circledC} 2005 American Chemical Society.",
author = "R. Joshi and M.S. Kumar and K. Satyamoorthy and M.K. Unnikrisnan and T. Mukherjee",
note = "Cited By :91 Export Date: 10 November 2017 CODEN: JAFCA Correspondence Address: Joshi, R.; Radiat. Chem. and Chem. Dynam. Div., Chemistry Group, Bhabha Atomic Research Centre, Mumbai 400085, India; email: rjudrin@yahoo.com Chemicals/CAS: deoxyribose, 533-67-5; hydroxyl radical, 3352-57-6; sesamol, 533-31-3; tryptophan, 6912-86-3, 73-22-3; Antioxidants; DNA, 9007-49-2; Deoxyribose, 533-67-5; Ferric Compounds; Free Radicals; Peroxides; Phenols; perhydroxyl radical, 3170-83-0; sesamol, 533-31-3 References: Ames, B.N., Dietary carcinogens and anticarcinogens (1983) Science, 227, pp. 1256-1264; Cadenas, E., Packer, L., (1996) Handbook of Antioxidants, , Marcel Dekker: New York; Aruoma, O.I., Nutrition and health aspects of free radical and antioxidants (1994) Free Radical Toxicol., 32, pp. 671-683; Proctor, P.H., Free radicals and human disease (1989) Handbook of Free Radicals and Antioxidants in Biomedicine, 1, pp. 209-221. , Miquel, J., Quintanilha, A. T., Weber, H., Eds.; CRC Press: Boca Raton, FL; Stocker, R., Frie, B., Endogenous antioxidant defense in human blood plasma (1991) Oxidative Stress: Oxidants and Antioxidants, pp. 213-243. , Sies, H., Ed.; Academic Press: London; Halliwell, B., Gutteridge, J.M.C., (1989) Free Radicals in Biology and Medicine, , Oxford University Press: Oxford; Cerutti, P.A., Prooxidant states and tumor promotion (1985) Science, 227, pp. 375-381; Budowski, P., Sesame oil III. Antioxidant properties of sesamol (1950) J. Am. Oil Chem. Soc., 27, pp. 264-270; Budowski, P., Menezes, F.G.T., Dollear, F.G., Sesame oil IV. The stability of sesame oil (1950) J. Am. Oil Chem. Soc., 27, pp. 377-380; Kikugawa, K., Arai, M., Kurechi, T., Participation of sesamol in stability of sesame oil (1983) J. Am. Oil Chem. Soc., 60, pp. 1528-1533; Kim, J.Y., Choi, D.S., Jung, M.Y., Antiphotooxidative activity of sesamol in methyleneblue- and chlorophyll-sensitized photooxidation of oil (2003) J. Agric. Food Chem., 51, pp. 3460-3465; Wright, J.S., Johnson, E.R., DiLabio, G.A., Predicting the activity of phenolic antioxidants: Theoretical method, analysis of substituent effects, and application to major families of antioxidants (2001) J. Am. Chem. Soc., 123, pp. 1173-1183; Joshi, R., Adhikari, S., Patro, B.S., Chattopadhyay, S., Mukherjee, T., Free radical scavenging behavior of folic acid: Evidence for possible antioxidant activity (2001) Free Radical Biol. Med., 30, pp. 1390-1399; Joshi, R., Kapoor, S., Mukherjee, T., Free radical reactions of pyridoxal (Vitamin B6): A pulse radiolysis study (2002) Res. Chem. Intermed., 28, pp. 505-515; McPhail, D.B., Hartley, R.C., Gardner, P.T., Duthie, G.G., Kinetic and stoichiometric assessment of the antioxidant activity of flavanoids by electron spin resonance spectroscopy (2003) J. Agric. Food Chem., 51, pp. 1684-1690; Mazziao, E.A., Harris, N., Soliman, K.F., Food constituents attenuate monoamine oxidase activity and peroxide levels in C6 astrocyte cells (1998) Planta Med., 64, pp. 603-606; Tseng, T.H., Tsheng, Y.M., Lee, Y.J., Cytotoxicity effects of di- and tri-hydroxybenzaldehydes as a chemopreventive potential agent on tumor cells (2001) Toxicology, 161, pp. 179-187; Tagashira, M., Ohtake, Y., A new antioxidant 1.3-benzodioxole from Melissa officinalis (1998) Planta Med., 64, pp. 555-558; Jurd, L., Narayana, V.L., Pauli, K.D., In vivo antitumor activity of 6-benzyl-1,3-benzodioxolederivatives against the P388, L1210, B16, and M5076 murine models (1987) J. Med. Chem., 30, pp. 1752-1756; Kumagai, Y., Lin, L.Y., Schmilz, D.A., Cho, A.K., Hydroxyl radical mediated demethylenation of (methlenedioxyl)phenyl compounds (1991) Chem. Res. Toxicol., 4, pp. 330-334; Chen, X., Ahn, D.U., Antioxidant activities of six natural phenolics against lipid peroxidation induced by Fe2+ or ultraviolet light (1998) J. Am. Oil Chem. Soc., 75, pp. 1717-1721; Kaur, I.P., Saini, A., Sesamol exhibits antimutagenic activity against oxygen species mediated mutagenicity (2000) Muta. Res., 470, pp. 71-76; Nakagawa, K., Photochemical reactions of antioxidant sesamol in aqueous solution (2000) J. Am. Oil Chem. Soc., 77, pp. 1205-1208; Nakagawa, K., Tero-Kuboto, S., Ikegami, Y., Tsuchihashi, N., EPR and TREPR studies of antioxidant sesamolyl and related phenoxyl radicals (1994) Photochem. Photobiol., 60, pp. 199-204; Tsutao, K., Kiyomi, K., Tetsuta, K., Studies on antioxidants. XIII. Hydrogen donating capability of antioxidants to 2,2-diphenyl-1-picrylhydrazyl (1980) Chem. Pharm. Bull., 28, pp. 2089-2093; Suja, K.P., Jayalekshmy, A., Arumughan, C., Free radical scavenging behavior of antioxidant compounds of sesame (Sesamum indicum L.) in DPPH system (2004) J. Agric. Food Chem., 52, pp. 912-915; Kato, T., Harashima, T., Moriya, N., Kikugawa, K., Hiramoto, K., Formation of the mutagenic/carcinogenic imidazoqunoxaline-type heterocyclic amines through the unstable free radical Maillard intermediates and its inhibition by phenolic antioxidants (1996) Carcinogenesis, 17, pp. 2469-2476; Hiramoto, K., Ojima, N., Sako, K., Kikugawa, K., Effect of plant phenolics on the formation of the spin-adduct of hydroxyl radical and the DNA strand breaking by hydroxyl radical (1996) Biol. Pharm. Bull., 19, pp. 558-563; Baxendale, J.H., Busi, F., (1982) The Study of Fast Processes and Transient Species by Electron Pulse Radiolysis, , D. Reidel Publishing Company: Dordrecht, The Netherlands; Mukherjee, T., Some recent studies of molecular dynamics at BARC (1997) Atomic, Molecular and Cluster Physics, pp. 299-316. , Ahmad, S. A., Ed.; Narosa: New Delhi; Buxton, G.V., Stuart, C.R., Reevaluation of the thiocyanate dosimeter for pulse radiolysis (1995) J. Chem. Soc., Faraday Trans., 97, pp. 279-281; Rajkumar, D.V., Rao, M.N.A., Antioxidant properties of phenyl styryl ketones (1995) Free Radical Res., 22, pp. 309-317; Braughler, J.M., Duncan, L.A., Chase, R.L., The involvement of iron in lipid peroxidation (1986) J. Biol. Chem., 261, pp. 10282-10289; Kunchandy, E., Rao, M.N.A., Effect of curcumin on hydroxyl radical generation through Fenton reaction (1989) Int. J. Pharm., 57, pp. 173-176; Buxton, G.V., Greenstock, C.L., Helman, W.P., Ross, A.B., Critical review of rate constants of hydrated electrons, hydrogen atoms and hydroxyl radicals (·OH/O.-) in aqueous solution (1988) J. Phys. Chem. Ref. Data, 77, pp. 513-886; Alfassi, Z.B., Schuler, R.H., Reaction of azide radicals with aromatic compounds. Azide as a selective oxidant (1985) J. Phys. Chem., 89, pp. 3359-3363; Neta, P., Huie, R.E., Ross, A.B., Rate constants for reactions of inorganic radicals in aqueous solution (1988) J. Phys. Chem. Ref. Data, 17, pp. 1027-1284; Das, T.N., Dhanasekaran, T., Alfassi, Z.B., Neta, P., Reduction potential of the tert-butyl peroxyl radical in aqueous solutions (1998) J. Phys. Chem. A, 702, pp. 280-284; Chevion, S., Roberts, M.A., Chevion, M., The use of cyclic voltammetry for the evaluation of antioxidant capacity (2000) Free Radical Biol. Med., 28, pp. 860-870; Steenken, S., Neta, P., One-electron redox potentials of phenols. Hydroxy and aminophenols and related compounds of biological interest (1982) J. Phys. Chem., 86, pp. 3661-3667; Sousa, W.R., DaRocha, C., Cardoso, C.L., Silva, D.H.S., Zanoni, M.V.B., Determination of the relative contribution of phenolic antioxidants in orange juice by voltammetric methods (2004) J. Food Compos. Anal., 17, pp. 619-633; Priyadarsini, K.I., Maity, D.K., Naik, G.H., Kumar, M.S., Unnikrishnan, M.K., Satav, J.G., Mohan, H., Role of phenolic O-H and methylene hydrogen on the free radical reactions and antioxidant activity of curcumin (2003) Free Radical Biol. Med., 55, pp. 475-484; Joshi, R., Mukherjee, T., Charge transfer between tryptophan and tyrosine in casein: A pulse radiolysis study (2002) Biophys. Chem., 96, pp. 15-19; Joshi, R., Mukherjee, T., Effect of solvent viscosity, polarity and pH on the charge transfer between tryptophan radical and tyrosine in bovine serum albumin: A pulse radiolysis study (2003) Biophys. Chem., 705, pp. 89-98; Schuler, R.H., Oxidation of ascorbate anion by electron transfer to phenoxyl radicals (1977) Radiat. Res., 69, pp. 417-433; Halliwell, B., How to characterize a biological antioxidant (1990) Free Radical Res. Commun., 9, pp. 1-32; Bindoli, A., Cavallini, L., Jocelyn, P., Mitochondrial lipid peroxidation by cumene hydroperoxide and its prevention by succinate (1982) Biochim. Biophys. Acta, 681, pp. 496-503; Sreejayan, Rao, M.N.A., Curcumin inhibits iron-dependent lipid peroxidation (1993) Int. J. Pharm., 100, pp. 93-97",
year = "2005",
doi = "10.1021/jf0489769",
language = "English",
volume = "53",
pages = "2696--2703",
journal = "Journal of Agricultural and Food Chemistry",
issn = "0021-8561",
publisher = "American Chemical Society",
number = "7",

}

Free radical reactions and antioxidant activities of sesamol: Pulse radiolytic and biochemical studies. / Joshi, R.; Kumar, M.S.; Satyamoorthy, K.; Unnikrisnan, M.K.; Mukherjee, T.

In: Journal of Agricultural and Food Chemistry, Vol. 53, No. 7, 2005, p. 2696-2703.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Free radical reactions and antioxidant activities of sesamol: Pulse radiolytic and biochemical studies

AU - Joshi, R.

AU - Kumar, M.S.

AU - Satyamoorthy, K.

AU - Unnikrisnan, M.K.

AU - Mukherjee, T.

N1 - Cited By :91 Export Date: 10 November 2017 CODEN: JAFCA Correspondence Address: Joshi, R.; Radiat. Chem. and Chem. Dynam. Div., Chemistry Group, Bhabha Atomic Research Centre, Mumbai 400085, India; email: rjudrin@yahoo.com Chemicals/CAS: deoxyribose, 533-67-5; hydroxyl radical, 3352-57-6; sesamol, 533-31-3; tryptophan, 6912-86-3, 73-22-3; Antioxidants; DNA, 9007-49-2; Deoxyribose, 533-67-5; Ferric Compounds; Free Radicals; Peroxides; Phenols; perhydroxyl radical, 3170-83-0; sesamol, 533-31-3 References: Ames, B.N., Dietary carcinogens and anticarcinogens (1983) Science, 227, pp. 1256-1264; Cadenas, E., Packer, L., (1996) Handbook of Antioxidants, , Marcel Dekker: New York; Aruoma, O.I., Nutrition and health aspects of free radical and antioxidants (1994) Free Radical Toxicol., 32, pp. 671-683; Proctor, P.H., Free radicals and human disease (1989) Handbook of Free Radicals and Antioxidants in Biomedicine, 1, pp. 209-221. , Miquel, J., Quintanilha, A. T., Weber, H., Eds.; CRC Press: Boca Raton, FL; Stocker, R., Frie, B., Endogenous antioxidant defense in human blood plasma (1991) Oxidative Stress: Oxidants and Antioxidants, pp. 213-243. , Sies, H., Ed.; Academic Press: London; Halliwell, B., Gutteridge, J.M.C., (1989) Free Radicals in Biology and Medicine, , Oxford University Press: Oxford; Cerutti, P.A., Prooxidant states and tumor promotion (1985) Science, 227, pp. 375-381; Budowski, P., Sesame oil III. Antioxidant properties of sesamol (1950) J. Am. Oil Chem. Soc., 27, pp. 264-270; Budowski, P., Menezes, F.G.T., Dollear, F.G., Sesame oil IV. The stability of sesame oil (1950) J. Am. Oil Chem. Soc., 27, pp. 377-380; Kikugawa, K., Arai, M., Kurechi, T., Participation of sesamol in stability of sesame oil (1983) J. Am. Oil Chem. Soc., 60, pp. 1528-1533; Kim, J.Y., Choi, D.S., Jung, M.Y., Antiphotooxidative activity of sesamol in methyleneblue- and chlorophyll-sensitized photooxidation of oil (2003) J. Agric. Food Chem., 51, pp. 3460-3465; Wright, J.S., Johnson, E.R., DiLabio, G.A., Predicting the activity of phenolic antioxidants: Theoretical method, analysis of substituent effects, and application to major families of antioxidants (2001) J. Am. Chem. Soc., 123, pp. 1173-1183; Joshi, R., Adhikari, S., Patro, B.S., Chattopadhyay, S., Mukherjee, T., Free radical scavenging behavior of folic acid: Evidence for possible antioxidant activity (2001) Free Radical Biol. Med., 30, pp. 1390-1399; Joshi, R., Kapoor, S., Mukherjee, T., Free radical reactions of pyridoxal (Vitamin B6): A pulse radiolysis study (2002) Res. Chem. Intermed., 28, pp. 505-515; McPhail, D.B., Hartley, R.C., Gardner, P.T., Duthie, G.G., Kinetic and stoichiometric assessment of the antioxidant activity of flavanoids by electron spin resonance spectroscopy (2003) J. Agric. Food Chem., 51, pp. 1684-1690; Mazziao, E.A., Harris, N., Soliman, K.F., Food constituents attenuate monoamine oxidase activity and peroxide levels in C6 astrocyte cells (1998) Planta Med., 64, pp. 603-606; Tseng, T.H., Tsheng, Y.M., Lee, Y.J., Cytotoxicity effects of di- and tri-hydroxybenzaldehydes as a chemopreventive potential agent on tumor cells (2001) Toxicology, 161, pp. 179-187; Tagashira, M., Ohtake, Y., A new antioxidant 1.3-benzodioxole from Melissa officinalis (1998) Planta Med., 64, pp. 555-558; Jurd, L., Narayana, V.L., Pauli, K.D., In vivo antitumor activity of 6-benzyl-1,3-benzodioxolederivatives against the P388, L1210, B16, and M5076 murine models (1987) J. Med. Chem., 30, pp. 1752-1756; Kumagai, Y., Lin, L.Y., Schmilz, D.A., Cho, A.K., Hydroxyl radical mediated demethylenation of (methlenedioxyl)phenyl compounds (1991) Chem. Res. Toxicol., 4, pp. 330-334; Chen, X., Ahn, D.U., Antioxidant activities of six natural phenolics against lipid peroxidation induced by Fe2+ or ultraviolet light (1998) J. Am. Oil Chem. Soc., 75, pp. 1717-1721; Kaur, I.P., Saini, A., Sesamol exhibits antimutagenic activity against oxygen species mediated mutagenicity (2000) Muta. Res., 470, pp. 71-76; Nakagawa, K., Photochemical reactions of antioxidant sesamol in aqueous solution (2000) J. Am. Oil Chem. Soc., 77, pp. 1205-1208; Nakagawa, K., Tero-Kuboto, S., Ikegami, Y., Tsuchihashi, N., EPR and TREPR studies of antioxidant sesamolyl and related phenoxyl radicals (1994) Photochem. Photobiol., 60, pp. 199-204; Tsutao, K., Kiyomi, K., Tetsuta, K., Studies on antioxidants. XIII. Hydrogen donating capability of antioxidants to 2,2-diphenyl-1-picrylhydrazyl (1980) Chem. Pharm. Bull., 28, pp. 2089-2093; Suja, K.P., Jayalekshmy, A., Arumughan, C., Free radical scavenging behavior of antioxidant compounds of sesame (Sesamum indicum L.) in DPPH system (2004) J. Agric. Food Chem., 52, pp. 912-915; Kato, T., Harashima, T., Moriya, N., Kikugawa, K., Hiramoto, K., Formation of the mutagenic/carcinogenic imidazoqunoxaline-type heterocyclic amines through the unstable free radical Maillard intermediates and its inhibition by phenolic antioxidants (1996) Carcinogenesis, 17, pp. 2469-2476; Hiramoto, K., Ojima, N., Sako, K., Kikugawa, K., Effect of plant phenolics on the formation of the spin-adduct of hydroxyl radical and the DNA strand breaking by hydroxyl radical (1996) Biol. Pharm. Bull., 19, pp. 558-563; Baxendale, J.H., Busi, F., (1982) The Study of Fast Processes and Transient Species by Electron Pulse Radiolysis, , D. Reidel Publishing Company: Dordrecht, The Netherlands; Mukherjee, T., Some recent studies of molecular dynamics at BARC (1997) Atomic, Molecular and Cluster Physics, pp. 299-316. , Ahmad, S. A., Ed.; Narosa: New Delhi; Buxton, G.V., Stuart, C.R., Reevaluation of the thiocyanate dosimeter for pulse radiolysis (1995) J. Chem. Soc., Faraday Trans., 97, pp. 279-281; Rajkumar, D.V., Rao, M.N.A., Antioxidant properties of phenyl styryl ketones (1995) Free Radical Res., 22, pp. 309-317; Braughler, J.M., Duncan, L.A., Chase, R.L., The involvement of iron in lipid peroxidation (1986) J. Biol. Chem., 261, pp. 10282-10289; Kunchandy, E., Rao, M.N.A., Effect of curcumin on hydroxyl radical generation through Fenton reaction (1989) Int. J. Pharm., 57, pp. 173-176; Buxton, G.V., Greenstock, C.L., Helman, W.P., Ross, A.B., Critical review of rate constants of hydrated electrons, hydrogen atoms and hydroxyl radicals (·OH/O.-) in aqueous solution (1988) J. Phys. Chem. Ref. Data, 77, pp. 513-886; Alfassi, Z.B., Schuler, R.H., Reaction of azide radicals with aromatic compounds. Azide as a selective oxidant (1985) J. Phys. Chem., 89, pp. 3359-3363; Neta, P., Huie, R.E., Ross, A.B., Rate constants for reactions of inorganic radicals in aqueous solution (1988) J. Phys. Chem. Ref. Data, 17, pp. 1027-1284; Das, T.N., Dhanasekaran, T., Alfassi, Z.B., Neta, P., Reduction potential of the tert-butyl peroxyl radical in aqueous solutions (1998) J. Phys. Chem. A, 702, pp. 280-284; Chevion, S., Roberts, M.A., Chevion, M., The use of cyclic voltammetry for the evaluation of antioxidant capacity (2000) Free Radical Biol. Med., 28, pp. 860-870; Steenken, S., Neta, P., One-electron redox potentials of phenols. Hydroxy and aminophenols and related compounds of biological interest (1982) J. Phys. Chem., 86, pp. 3661-3667; Sousa, W.R., DaRocha, C., Cardoso, C.L., Silva, D.H.S., Zanoni, M.V.B., Determination of the relative contribution of phenolic antioxidants in orange juice by voltammetric methods (2004) J. Food Compos. Anal., 17, pp. 619-633; Priyadarsini, K.I., Maity, D.K., Naik, G.H., Kumar, M.S., Unnikrishnan, M.K., Satav, J.G., Mohan, H., Role of phenolic O-H and methylene hydrogen on the free radical reactions and antioxidant activity of curcumin (2003) Free Radical Biol. Med., 55, pp. 475-484; Joshi, R., Mukherjee, T., Charge transfer between tryptophan and tyrosine in casein: A pulse radiolysis study (2002) Biophys. Chem., 96, pp. 15-19; Joshi, R., Mukherjee, T., Effect of solvent viscosity, polarity and pH on the charge transfer between tryptophan radical and tyrosine in bovine serum albumin: A pulse radiolysis study (2003) Biophys. Chem., 705, pp. 89-98; Schuler, R.H., Oxidation of ascorbate anion by electron transfer to phenoxyl radicals (1977) Radiat. Res., 69, pp. 417-433; Halliwell, B., How to characterize a biological antioxidant (1990) Free Radical Res. Commun., 9, pp. 1-32; Bindoli, A., Cavallini, L., Jocelyn, P., Mitochondrial lipid peroxidation by cumene hydroperoxide and its prevention by succinate (1982) Biochim. Biophys. Acta, 681, pp. 496-503; Sreejayan, Rao, M.N.A., Curcumin inhibits iron-dependent lipid peroxidation (1993) Int. J. Pharm., 100, pp. 93-97

PY - 2005

Y1 - 2005

N2 - Sesamol (from Sesamum indicum) is a dietary compound, which is soluble in aqueous as well as lipid phases. Free radical scavenging reactions of sesamol, 5-hydroxy-1,3-benzodioxole, have been studied using a nanosecond pulse radiolysis technique. Sesamol efficiently scavenges hydroxyl, one-electron oxidizing, organo-haloperoxyl, lipid peroxyl, and tryptophanyl radicals. Its antioxidant activity has also been evaluated with cyclic voltammetry. In biochemical studies, it has been found to inhibit lipid peroxidation, hydroxyl radical-induced deoxyribose degradation, and DNA cleavage. These antioxidant and free radical scavenging activities of sesamol have been reported in the paper. © 2005 American Chemical Society.

AB - Sesamol (from Sesamum indicum) is a dietary compound, which is soluble in aqueous as well as lipid phases. Free radical scavenging reactions of sesamol, 5-hydroxy-1,3-benzodioxole, have been studied using a nanosecond pulse radiolysis technique. Sesamol efficiently scavenges hydroxyl, one-electron oxidizing, organo-haloperoxyl, lipid peroxyl, and tryptophanyl radicals. Its antioxidant activity has also been evaluated with cyclic voltammetry. In biochemical studies, it has been found to inhibit lipid peroxidation, hydroxyl radical-induced deoxyribose degradation, and DNA cleavage. These antioxidant and free radical scavenging activities of sesamol have been reported in the paper. © 2005 American Chemical Society.

U2 - 10.1021/jf0489769

DO - 10.1021/jf0489769

M3 - Article

VL - 53

SP - 2696

EP - 2703

JO - Journal of Agricultural and Food Chemistry

JF - Journal of Agricultural and Food Chemistry

SN - 0021-8561

IS - 7

ER -