Free radical reactions and antioxidant activities of sesamol: Pulse radiolytic and biochemical studies

R. Joshi, M.S. Kumar, K. Satyamoorthy, M.K. Unnikrisnan, T. Mukherjee

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Sesamol (from Sesamum indicum) is a dietary compound, which is soluble in aqueous as well as lipid phases. Free radical scavenging reactions of sesamol, 5-hydroxy-1,3-benzodioxole, have been studied using a nanosecond pulse radiolysis technique. Sesamol efficiently scavenges hydroxyl, one-electron oxidizing, organo-haloperoxyl, lipid peroxyl, and tryptophanyl radicals. Its antioxidant activity has also been evaluated with cyclic voltammetry. In biochemical studies, it has been found to inhibit lipid peroxidation, hydroxyl radical-induced deoxyribose degradation, and DNA cleavage. These antioxidant and free radical scavenging activities of sesamol have been reported in the paper. © 2005 American Chemical Society.
Original languageEnglish
Pages (from-to)2696-2703
Number of pages8
JournalJournal of Agricultural and Food Chemistry
Issue number7
Publication statusPublished - 2005


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