Free radical scavenging activity of aqueous extract of Sphaeranthus indicus (LINN)

K.S. Prabhu, R. Lobo, A. Shirwaikar

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

The free radical scavenging potential of the plant Sphaeranthus indicus Linn. was studied by using different antioxidant models of screening. The aqueous extract at 1000 μg/ml showed maximum scavenging of the radical cation, 2,2-azinobis-(3-ethylbenzothiazoline-6-sulphonate) (ABTS) observed upto 26.21 % followed by the scavenging of the stable radical 1,1-diphenyl, 2-picryl hydrazyl (DPPH) (24.95 %), superoxide dismutase (17.74 %) and nitric oxide radical (10.63 %) at the same concentration. However, the extract showed only moderate scavenging activity of iron chelation (9.62 %). Total antioxidant capacity of the extract was found to be 127.85 nmol/g ascorbic acid. The findings justify the therapeutic applications of the plant in the indigenous system of medicine, augmenting its therapeutic value.
Original languageEnglish
Pages (from-to)468-476
Number of pages9
JournalPharmacologyonline
Volume2
Publication statusPublished - 2009

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