@article{24b86c1203c949f2b9238ba895c313cb,
title = "Free radical scavenging activity of aqueous extract of Sphaeranthus indicus (LINN)",
abstract = "The free radical scavenging potential of the plant Sphaeranthus indicus Linn. was studied by using different antioxidant models of screening. The aqueous extract at 1000 μg/ml showed maximum scavenging of the radical cation, 2,2-azinobis-(3-ethylbenzothiazoline-6-sulphonate) (ABTS) observed upto 26.21 % followed by the scavenging of the stable radical 1,1-diphenyl, 2-picryl hydrazyl (DPPH) (24.95 %), superoxide dismutase (17.74 %) and nitric oxide radical (10.63 %) at the same concentration. However, the extract showed only moderate scavenging activity of iron chelation (9.62 %). Total antioxidant capacity of the extract was found to be 127.85 nmol/g ascorbic acid. The findings justify the therapeutic applications of the plant in the indigenous system of medicine, augmenting its therapeutic value.",
author = "K.S. Prabhu and R. Lobo and A. Shirwaikar",
note = "Cited By :3 Export Date: 10 November 2017 Correspondence Address: Shirwaikar, A.; Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal 576 104, India; email: annieshirwaikar@yahoo.com Chemicals/CAS: 1,1 diphenyl 2 picrylhydrazyl, 1898-66-4; 2,2' azinobis(3 ethylbenzothiazoline 6 sulfonic acid), 28752-68-3; ascorbic acid, 134-03-2, 15421-15-5, 50-81-7; nitric oxide, 10102-43-9; superoxide dismutase, 37294-21-6, 9016-01-7, 9054-89-1; water, 7732-18-5 References: Cross, C.E., Oxygen radicals and human disease (1987) Annal Int Med, 107, pp. 526-545; Marx, J.L., Oxygen free radicals linked to many diseases (1987) Science, 235, pp. 529-531; Ajay, A., Sairam, R.K., Srivastava, G.C., Oxidative stress and antioxidative system in plants (2002) Curr Sci, 82, pp. 1227-1238; Geesin, J.G., Gordon, J.S., Berg, R.A., Retinoids affect collagen synthesis through inhibition of ascorbate-induced lipid peroxidation in cultured human dermal fibroblasts (1990) Arch Biochem Biophys, 278, pp. 352-355; Warrier, P.K., Nambiar, V.P.K., Raman Kutty, C., (2004) Indian Medicinal Plants, 1, p. 180. , Orient Longman, Hyderabad, India; Prabhu, K.S., Lobo, R., Dinesh, K., Rajendran, K., Annie, S., Pharmacognostical evaluation of Sphaeranthus indicus (Linn) (2006) Natural Product Sciences, 12, pp. 85-89; Gupta, N.S., (1984) Ayurvedic system of medicine, 2. , In The, Logas Press, New Delhi, India; Paranjape, P., In Indian medicinal plants (2001) Forgotten healer: A guide to Ayurvedic herbal medicine. Chaukhamba Sanskrit Pratisthan, p. 148. , Delhi, India; Baslas, K.K., Essential oil from Sphaeranthus indicus (1959) Perf Ess Oil Rec, 50, pp. 765-768; Basu, N.K., Lamsal, P.P., Chemical investigation of Sphaeranthus indicus Linn (1946) J Am Pharm Asso, 29, pp. 274-280; Gupta, R.K., Chandra, S., Mahandevan, V., Chemical composition of Sphaeranthus indicus Linn (1967) Indian J Pharm, 29, pp. 47-48; Gogate, M.G., Ananthasubramanian, L., Nargund, K.S., Bhattacharyya, S.C., Some interesting sesquiterpinoids from Sphaeranthus indicus Linn. (Compositae) (1986) Indian J Chem, 25, pp. 233-240; Shekhani, M.S., Shah, P.M., Yasmin, A., Siddiqui, R., Perveen, S., Khan, K.M., An immunostimulant sesquiterpene glycoside from Sphaeranthus indicus (1990) Phytochem, 29, pp. 2573-2576; Yadav RN, Kumar S. 7-Hydroxy-3′, 4′, 5, 6-tetramethoxy flavone 7-O-b-D-(14)-diglucoside, a new flavone glycoside from the stem of Sphaeranthus indicus. J Inst Chem. 1998; 70:164-166; Marx, J.L., Oxygen free radicals linked to many diseases (1987) Science, 235, pp. 529-531; Shirwaikar, A., Rajendran, K., Dinesh, K., In vitro antioxidant studies of Annona squamosa (2004) Indian J Exp Biol, 142, pp. 803-807; Sreejayan, N., Rao, M.N.A., Free radical scavenging activity of curcuminoids (1996) Drug Res, 46, pp. 169-171; Sanchez-Moreno, C., Methods used to evaluate the free radical scavenging activity in foods and biological systems (2002) Food Sci Tech Int, 8, pp. 122-128; Henry, L.E.A., Halliwell, B., Hall, D.O., The superoxide dismutase activity of various photosynthetic organisms measured by a new and a rapid assay technique (1976) FEBS Lett, 66, pp. 303-306; Sreejayan, N., Rao, M.N.A., Nitric oxide scavenging by curcuminoids (1997) J Pharm Pharmacol, 49, pp. 105-107; Shirwaikar, A., Somashekar, A.P., Antiinflammatory activity and free radical scavenging studies of Aristolochia bracteolata Lam (2003) Indian J Pharm Sci, 65, pp. 67-69; Green, L.C., Wagner, D.A., Glogowski, J., Skipper, P.L., Wishnok, J.S., Tannenbaum, S.R., Analysis of nitrate and 15N in biological fluids (1982) Anal Biochem, 126, pp. 131-138; Marcocci, L., Maguire, J.J., Droy-Lefaix, M.T., Packer, L., The nitric oxide scavenging property of Ginko biloba extract EGB 761 (1994) Biochem Biophys Res Commun, 201, pp. 748-755; Benzie IFF, Strain JT. The Ferric reducing ability of plasma (FRAP) as a measure of Antioxidant Power: The FRAP assay. Anal. Biochem. 1996; 239:70-76; Benzie, I.F.F., Szeto, Y.T., Total antioxidant capacity of Teas by the Ferric Reducing/Antioxidant power assay (1999) J Agric Food Chem, 47, pp. 633-636; Annie, S., Govindrajan, R., Rastogi, S., Vijaykumar, M., Rawat, A.K.S., Mehlotra, S., Pushpangadan, P., Studies on the Antioxidant activities of Desmodium gangeticum (2003) Biol Pharm Bull, 26, p. 1424; Youdim, K.A., Joseph, J.A., A possible emerging role of phytochemicals in improving age-related neurological dysfunctions: A multiplicity of effects (2001) Free Rad Biol Med, 30, pp. 583-594; Rice-Evans, C., Miller, N.J., Factors influencing the antioxidant activity determined by the ABTS.+ radical cation assay (1997) Free Rad Res, 26, pp. 195-199; Blois, M.S., Antioxidant determinations by the use of stable free radical (1958) Nature, 26, pp. 1199-1200; Kamalakkannan, N., Stanley, Mainzen Prince, P., Effect of Aegle marmelos fruit extract on tissue antioxidants in streptozotocin diabetic rats (2003) Indian J Exp Biol, 41, p. 1288; Ray, G., Akhtar Husain, S., Oxidents, antioxidants and carcinogenesis (2002) Indian J Exp Biol, 40, p. 1214; Ialenti, A., Moncada, S., Di Rosa, M., Modulation of adjuvant arthritis by endogenous nitric oxide (1993) Brit J Pharmacol, 110, pp. 701-706; Marcocci, L., Packer, L., Droy-Lefaiz, M.T., Sekaki, A., Gardes-Albert, M., Antioxidant action of Ginko biloba extract Egb 761 (1994) Meth Enzymol, 234, p. 462; Sanchez, M.C., Methods used to evaluate the free radical scavenging activity in foods and biological systems (2002) Food-Sci. Tech. Int, 8, p. 122",
year = "2009",
language = "English",
volume = "2",
pages = "468--476",
journal = "Pharmacologyonline",
issn = "1827-8620",
publisher = "SILAE (Italo-Latin American Society of Ethnomedicine)",
}