Free radical scavenging activity of curcuminoids

N. Sreejayan, M.N.A. Rao

Research output: Contribution to journalArticle

419 Citations (Scopus)

Abstract

Three natural curcuminoids (curcumin (CAS 458-37-7), demethoxycurcumin, bisdemethoxycurcumin) and acetylcurcumin were compared for their ability to scavenge superoxide radicals and to interact with 1,1-diphenyl-2-picryl-hydrazyl (DPPH) stable free radicals. The results showed that curcumin is the most potent scavenger of superoxide radicals followed by demethoxycurcumin and bisdemethoxycurcumin. Acetylcurcumin was inactive. Interaction with DPPH showed a similar activity profile. The study indicates that the phenolic group is essential for the free radical scavenging activity and presence of methoxy group further increases the activity.
Original languageUndefined/Unknown
Pages (from-to)169-171
Number of pages3
JournalArzneimittel-Forschung/Drug Research
Volume46
Issue number2
Publication statusPublished - 1996

Cite this

Sreejayan, N., & Rao, M. N. A. (1996). Free radical scavenging activity of curcuminoids. Arzneimittel-Forschung/Drug Research, 46(2), 169-171.
Sreejayan, N. ; Rao, M.N.A. / Free radical scavenging activity of curcuminoids. In: Arzneimittel-Forschung/Drug Research. 1996 ; Vol. 46, No. 2. pp. 169-171.
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Sreejayan, N & Rao, MNA 1996, 'Free radical scavenging activity of curcuminoids', Arzneimittel-Forschung/Drug Research, vol. 46, no. 2, pp. 169-171.

Free radical scavenging activity of curcuminoids. / Sreejayan, N.; Rao, M.N.A.

In: Arzneimittel-Forschung/Drug Research, Vol. 46, No. 2, 1996, p. 169-171.

Research output: Contribution to journalArticle

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T1 - Free radical scavenging activity of curcuminoids

AU - Sreejayan, N.

AU - Rao, M.N.A.

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PY - 1996

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AB - Three natural curcuminoids (curcumin (CAS 458-37-7), demethoxycurcumin, bisdemethoxycurcumin) and acetylcurcumin were compared for their ability to scavenge superoxide radicals and to interact with 1,1-diphenyl-2-picryl-hydrazyl (DPPH) stable free radicals. The results showed that curcumin is the most potent scavenger of superoxide radicals followed by demethoxycurcumin and bisdemethoxycurcumin. Acetylcurcumin was inactive. Interaction with DPPH showed a similar activity profile. The study indicates that the phenolic group is essential for the free radical scavenging activity and presence of methoxy group further increases the activity.

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JF - Drug Research

SN - 2194-9379

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