Three natural curcuminoids (curcumin (CAS 458-37-7), demethoxycurcumin, bisdemethoxycurcumin) and acetylcurcumin were compared for their ability to scavenge superoxide radicals and to interact with 1,1-diphenyl-2-picryl-hydrazyl (DPPH) stable free radicals. The results showed that curcumin is the most potent scavenger of superoxide radicals followed by demethoxycurcumin and bisdemethoxycurcumin. Acetylcurcumin was inactive. Interaction with DPPH showed a similar activity profile. The study indicates that the phenolic group is essential for the free radical scavenging activity and presence of methoxy group further increases the activity.
|Number of pages||3|
|Publication status||Published - 1996|
Sreejayan, N., & Rao, M. N. A. (1996). Free radical scavenging activity of curcuminoids. Arzneimittel-Forschung/Drug Research, 46(2), 169-171. https://www.scopus.com/inward/record.uri?eid=2-s2.0-0029935490&partnerID=40&md5=94f625d7d1414bf1efb557f773e53fc2