Free radical scavenging activity of extracts of young prop roots of ficus bengalensis

Research output: Contribution to journalArticle

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Abstract

The various parts of Indian medicinal plant Ficus bengalensis Linn. (Moraceae) is used in the Indigenous System of Medicine and known for its wide therapeutic benefits. The extracts of young prop roots of Ficus bengalensis was evaluated for its free radical scavenging activity in different methods viz. DPPH (2,2-diphenyl-1-picrylhydrazyl) assay, ABTS [2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid)] radical scavenging assay and iron chelation activity using orthophenathroline. The results were analyzed statistically by regression method. In all the methods the alcoholic and aqueous extracts showed concentration dependent radical scavenging activity and the IC50 values were 50.87 and 95.7 μg/ml for DPPH assay, 49.23 and 103.08 μg/ml for iron chelating activity, 19.89 and 392 μg/ml for ABTS scavenging. The alcoholic extract exhibited promising antioxidant activity compared to aqueous extracts and the results were comparable with standard antioxidant ascorbic acid.

Original languageEnglish
Pages (from-to)299-307
Number of pages9
JournalPharmacologyonline
Volume2
Publication statusPublished - 2010

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Ficus
Free Radicals
Iron
Antioxidants
Moraceae
Traditional Medicine
Medicinal Plants
Systems Analysis
Ascorbic Acid
Inhibitory Concentration 50
2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid
2,2-diphenyl-1-picrylhydrazyl
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery

Cite this

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abstract = "The various parts of Indian medicinal plant Ficus bengalensis Linn. (Moraceae) is used in the Indigenous System of Medicine and known for its wide therapeutic benefits. The extracts of young prop roots of Ficus bengalensis was evaluated for its free radical scavenging activity in different methods viz. DPPH (2,2-diphenyl-1-picrylhydrazyl) assay, ABTS [2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid)] radical scavenging assay and iron chelation activity using orthophenathroline. The results were analyzed statistically by regression method. In all the methods the alcoholic and aqueous extracts showed concentration dependent radical scavenging activity and the IC50 values were 50.87 and 95.7 μg/ml for DPPH assay, 49.23 and 103.08 μg/ml for iron chelating activity, 19.89 and 392 μg/ml for ABTS scavenging. The alcoholic extract exhibited promising antioxidant activity compared to aqueous extracts and the results were comparable with standard antioxidant ascorbic acid.",
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Free radical scavenging activity of extracts of young prop roots of ficus bengalensis. / Nidhiya, I. S.R.; Pai, K.S.R.; Mallikarjuna Rao, C.

In: Pharmacologyonline, Vol. 2, 2010, p. 299-307.

Research output: Contribution to journalArticle

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