Free radical scavenging and anticancer activity of clerodendron paniculatum

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Oxidative stress has been implicated in numerous pathophysiological conditions including cancer. Conventional medical treatment has its own side effects besides the high cost. A simple but effective way of preventing cancer may be to prevent oxidative damage. In the recent years, several antioxidant phenolic compounds have been recognized to have ability to induce apoptosis in various tumour cells of human origin. By virtue of their antioxidant property, they also prevent cell growth by inhibiting the proteins responsible for cell growth. Ethno botanical search reveals use of many traditional herbs in treatment of cancer, which are usually free from side effects, are economical and also easily accessible to humans. However, their mechanism of action is not known. The plant Clerodendron paniculatum is a plant widely found in Udupi district of Karnataka, India. The present study was undertaken to evaluate the possible anticancer effects of alcoholic extract of the plant. Although, plants of the same genus were reported to possess potent anticancer activity, no reports were available on this plant. The plants of the genus Clerodendron were reported to have antioxidant and anti-inflammatory activities also. The extract was also studied for free radical scavenging potential. Although the extract showed significant antioxidant activity, its anticancer potential was not significant.
Original languageEnglish
Pages (from-to)730-743
Number of pages14
JournalPharmacologyonline
Volume3
Publication statusPublished - 2008

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Clerodendrum
Free Radicals
Antioxidants
Neoplasms
Plant Extracts
Growth
India
Oxidative Stress
Anti-Inflammatory Agents
Apoptosis
Costs and Cost Analysis
Proteins

Cite this

@article{e712cfb668c646c9a6729d506e500af8,
title = "Free radical scavenging and anticancer activity of clerodendron paniculatum",
abstract = "Oxidative stress has been implicated in numerous pathophysiological conditions including cancer. Conventional medical treatment has its own side effects besides the high cost. A simple but effective way of preventing cancer may be to prevent oxidative damage. In the recent years, several antioxidant phenolic compounds have been recognized to have ability to induce apoptosis in various tumour cells of human origin. By virtue of their antioxidant property, they also prevent cell growth by inhibiting the proteins responsible for cell growth. Ethno botanical search reveals use of many traditional herbs in treatment of cancer, which are usually free from side effects, are economical and also easily accessible to humans. However, their mechanism of action is not known. The plant Clerodendron paniculatum is a plant widely found in Udupi district of Karnataka, India. The present study was undertaken to evaluate the possible anticancer effects of alcoholic extract of the plant. Although, plants of the same genus were reported to possess potent anticancer activity, no reports were available on this plant. The plants of the genus Clerodendron were reported to have antioxidant and anti-inflammatory activities also. The extract was also studied for free radical scavenging potential. Although the extract showed significant antioxidant activity, its anticancer potential was not significant.",
author = "J. John and {Jesil Mathew}, A. and {Manjunath Setty}, M.",
note = "Cited By :2 Export Date: 10 November 2017 Correspondence Address: Manjunath Setty, M.; Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal 576104, India; email: mm.setty@manipal.edu Chemicals/CAS: ascorbic acid, 134-03-2, 15421-15-5, 50-81-7; cisplatin, 15663-27-1, 26035-31-4, 96081-74-2 References: Sreejayan, N., Rao, M.N.A., Free radical scavenging activity of curcuminoids (1996) Drug Research, 46, p. 169; Miller, N.J., Rice, C.A., Total antioxidant status in plasma and body fluids (1994) Methods in enzymology, 234, p. 279; Echardt, A.E., Malone, B.N., Goldstein, I., Inhibition of Ehrlich Ascites Tumor Cell Growth by Griffonia simplicifolia I Lectin in Vivo (1982) Cancer Res, 42, pp. 2977-2979; Atia, M.A., Weiss, D.W., Immunology of spontaneous mammary carcinomas in mice (1996) Cancer Research, 26, pp. 1787-1900; http://www.epa.gov/scipoly/sap/meeting/2001/december/12/upanddown.pdf, OECD Guidelines for acute toxicity studies; Chen, P.M., Yung, L.L., Hsiao, K.I., Chen, C.M., Yeh, H.M., Chuang, M.H., Tzeng, C.H., In vitro induction of differentiation in HL-60 leukemic cell line by clerodendron fragrans (1988) Am J Chin Med, 16, pp. 139-144; Manoharan, S., Kavitha, K., Senthil, N., Renju, G.L., Evaluation of anticarcinogenic effects of Clerodendron inerme on 7, 12-dimethylbenz (a) anthracene-induced hamster buccal pouch carcinogenesis (2006) Singapore Med J, 47, pp. 1038-1043; Panthong A, Kanjanapothi D, Taesotikul T, Wongcome T, Reutrakul VJ. Anti-inflammatory and antipyretic properties of Clerodendrum petasites S. Moore Ethnopharmacol 2003; 85; 151-6; Choi, J.H., Whang, W.K., Kim, H.J., Studies on the anti-inflammatory effects of Clerodendron trichotomum Thunberg leaves (2004) Arch Pharm Res, 27, pp. 189-193; Chae S, Kim JS, Kang KA, Bu HD, Lee Y, Seo YR, Hyun JW, Kang SS. Trichotomoside: a new antioxidative phenylpropanoid glycoside from Clerodendron trichotomum. Chem Biodivers 2006; 3; 41-8UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-58149260182&partnerID=40&md5=1a6d099ad87aa67586ff5e98d8558e71",
year = "2008",
language = "English",
volume = "3",
pages = "730--743",
journal = "Pharmacologyonline",
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Free radical scavenging and anticancer activity of clerodendron paniculatum. / John, J.; Jesil Mathew, A.; Manjunath Setty, M.

In: Pharmacologyonline, Vol. 3, 2008, p. 730-743.

Research output: Contribution to journalArticle

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T1 - Free radical scavenging and anticancer activity of clerodendron paniculatum

AU - John, J.

AU - Jesil Mathew, A.

AU - Manjunath Setty, M.

N1 - Cited By :2 Export Date: 10 November 2017 Correspondence Address: Manjunath Setty, M.; Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal 576104, India; email: mm.setty@manipal.edu Chemicals/CAS: ascorbic acid, 134-03-2, 15421-15-5, 50-81-7; cisplatin, 15663-27-1, 26035-31-4, 96081-74-2 References: Sreejayan, N., Rao, M.N.A., Free radical scavenging activity of curcuminoids (1996) Drug Research, 46, p. 169; Miller, N.J., Rice, C.A., Total antioxidant status in plasma and body fluids (1994) Methods in enzymology, 234, p. 279; Echardt, A.E., Malone, B.N., Goldstein, I., Inhibition of Ehrlich Ascites Tumor Cell Growth by Griffonia simplicifolia I Lectin in Vivo (1982) Cancer Res, 42, pp. 2977-2979; Atia, M.A., Weiss, D.W., Immunology of spontaneous mammary carcinomas in mice (1996) Cancer Research, 26, pp. 1787-1900; http://www.epa.gov/scipoly/sap/meeting/2001/december/12/upanddown.pdf, OECD Guidelines for acute toxicity studies; Chen, P.M., Yung, L.L., Hsiao, K.I., Chen, C.M., Yeh, H.M., Chuang, M.H., Tzeng, C.H., In vitro induction of differentiation in HL-60 leukemic cell line by clerodendron fragrans (1988) Am J Chin Med, 16, pp. 139-144; Manoharan, S., Kavitha, K., Senthil, N., Renju, G.L., Evaluation of anticarcinogenic effects of Clerodendron inerme on 7, 12-dimethylbenz (a) anthracene-induced hamster buccal pouch carcinogenesis (2006) Singapore Med J, 47, pp. 1038-1043; Panthong A, Kanjanapothi D, Taesotikul T, Wongcome T, Reutrakul VJ. Anti-inflammatory and antipyretic properties of Clerodendrum petasites S. Moore Ethnopharmacol 2003; 85; 151-6; Choi, J.H., Whang, W.K., Kim, H.J., Studies on the anti-inflammatory effects of Clerodendron trichotomum Thunberg leaves (2004) Arch Pharm Res, 27, pp. 189-193; Chae S, Kim JS, Kang KA, Bu HD, Lee Y, Seo YR, Hyun JW, Kang SS. Trichotomoside: a new antioxidative phenylpropanoid glycoside from Clerodendron trichotomum. Chem Biodivers 2006; 3; 41-8UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-58149260182&partnerID=40&md5=1a6d099ad87aa67586ff5e98d8558e71

PY - 2008

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N2 - Oxidative stress has been implicated in numerous pathophysiological conditions including cancer. Conventional medical treatment has its own side effects besides the high cost. A simple but effective way of preventing cancer may be to prevent oxidative damage. In the recent years, several antioxidant phenolic compounds have been recognized to have ability to induce apoptosis in various tumour cells of human origin. By virtue of their antioxidant property, they also prevent cell growth by inhibiting the proteins responsible for cell growth. Ethno botanical search reveals use of many traditional herbs in treatment of cancer, which are usually free from side effects, are economical and also easily accessible to humans. However, their mechanism of action is not known. The plant Clerodendron paniculatum is a plant widely found in Udupi district of Karnataka, India. The present study was undertaken to evaluate the possible anticancer effects of alcoholic extract of the plant. Although, plants of the same genus were reported to possess potent anticancer activity, no reports were available on this plant. The plants of the genus Clerodendron were reported to have antioxidant and anti-inflammatory activities also. The extract was also studied for free radical scavenging potential. Although the extract showed significant antioxidant activity, its anticancer potential was not significant.

AB - Oxidative stress has been implicated in numerous pathophysiological conditions including cancer. Conventional medical treatment has its own side effects besides the high cost. A simple but effective way of preventing cancer may be to prevent oxidative damage. In the recent years, several antioxidant phenolic compounds have been recognized to have ability to induce apoptosis in various tumour cells of human origin. By virtue of their antioxidant property, they also prevent cell growth by inhibiting the proteins responsible for cell growth. Ethno botanical search reveals use of many traditional herbs in treatment of cancer, which are usually free from side effects, are economical and also easily accessible to humans. However, their mechanism of action is not known. The plant Clerodendron paniculatum is a plant widely found in Udupi district of Karnataka, India. The present study was undertaken to evaluate the possible anticancer effects of alcoholic extract of the plant. Although, plants of the same genus were reported to possess potent anticancer activity, no reports were available on this plant. The plants of the genus Clerodendron were reported to have antioxidant and anti-inflammatory activities also. The extract was also studied for free radical scavenging potential. Although the extract showed significant antioxidant activity, its anticancer potential was not significant.

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