The plant Hybanthus enneaspermus have been widely used traditionally to treat variety of common and stress related disorders. In the present investigation, the ethanol and aqueous extracts of Hybanthus enneaspermus were studied for its nephroprotective activity in cisplatin induced renal injury in rats. The extracts at dose levels of 250 and 500mg/kg showed dose- dependent reduction in the elevated blood urea and serum creatinine. Treatment with the alcoholic and aqueous extracts of Hybanthus enneaspermus increased GSH, GST and SOD level and inhibited the lipid peroxidation induced by cisplatin in the kidney homogenate. Cisplatin administration resulted in increased blood urea and serum creatinine levels which were reversed by the alcoholic and aqueous extracts of Hybanthus enneaspermus. The results suggest that the alcoholic and aqueous extracts of the Hybanthus enneaspermus possesses significant curative and preventive nephroprotective activity. Furthermore, the extract was studied for free radical scavenging potential to correlate its nephroprotective activity.
|Number of pages||14|
|Publication status||Published - 2007|
Manjunath Setty, M., Narayanaswamy, V. B., Sreenivasan, K. K., & Shirwaikar, A. (2007). Free radical scavenging and nephroprotective activity of Hybanthus enneaspermus (L) F.Muell. Pharmacologyonline, 2, 158-171.