Free radical toxicity and antioxidants in Guillain-Barre syndrome, a preliminary study

Kiran T. Kumar, A. Chandrika, Krishna N. Sumanth, P. Sireesha, Suryanarayana Rao, Anjali Rao

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background. The generation of reactive oxygen species (ROS) has been implicated in the pathogenesis of a vast array of disease processes including some neurological disorders. Method. Ten patients with Guillain-Barre syndrome (GBS) and 10 age and sex-matched controls were included in this study. The erythrocyte glutathione (GSH), superoxide dismutase (SOD) and malondialdehyde (MDA) levels, as well as plasma antioxidant vitamins C and E and serum glutathione-S-transferase (GST) levels were estimated spectrophotometrically. Results. The plasma vitamin E and the serum total glutathione-S-transferase levels were markedly increased in both pre- and post-treated cases of GBS when compared to controls. The erythrocyte glutathione and malondialdehyde levels were significantly reduced in GBS cases when compared to normals. However, plasma vitamin C and erythrocyte superoxide dismutase were not altered when compared to controls. Conclusion. Free radical toxicity may have an influence in patients suffering from GBS.

Original languageEnglish
Pages (from-to)205-209
Number of pages5
JournalClinica Chimica Acta
Volume346
Issue number2
DOIs
Publication statusPublished - 16-08-2004
Externally publishedYes

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Guillain-Barre Syndrome
Free Radicals
Toxicity
Antioxidants
Glutathione Transferase
Malondialdehyde
Vitamin E
Plasmas
Ascorbic Acid
Superoxide Dismutase
Glutathione
Erythrocytes
Reactive Oxygen Species
Nervous System Diseases
Serum

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Kumar, K. T., Chandrika, A., Sumanth, K. N., Sireesha, P., Rao, S., & Rao, A. (2004). Free radical toxicity and antioxidants in Guillain-Barre syndrome, a preliminary study. Clinica Chimica Acta, 346(2), 205-209. https://doi.org/10.1016/j.cccn.2004.03.032
Kumar, Kiran T. ; Chandrika, A. ; Sumanth, Krishna N. ; Sireesha, P. ; Rao, Suryanarayana ; Rao, Anjali. / Free radical toxicity and antioxidants in Guillain-Barre syndrome, a preliminary study. In: Clinica Chimica Acta. 2004 ; Vol. 346, No. 2. pp. 205-209.
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Kumar, KT, Chandrika, A, Sumanth, KN, Sireesha, P, Rao, S & Rao, A 2004, 'Free radical toxicity and antioxidants in Guillain-Barre syndrome, a preliminary study', Clinica Chimica Acta, vol. 346, no. 2, pp. 205-209. https://doi.org/10.1016/j.cccn.2004.03.032

Free radical toxicity and antioxidants in Guillain-Barre syndrome, a preliminary study. / Kumar, Kiran T.; Chandrika, A.; Sumanth, Krishna N.; Sireesha, P.; Rao, Suryanarayana; Rao, Anjali.

In: Clinica Chimica Acta, Vol. 346, No. 2, 16.08.2004, p. 205-209.

Research output: Contribution to journalArticle

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