Free radical toxicity and antioxidants in Guillain-Barre syndrome, a preliminary study

Kiran T. Kumar, A. Chandrika, Krishna N. Sumanth, P. Sireesha, Suryanarayana Rao, Anjali Rao

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Background. The generation of reactive oxygen species (ROS) has been implicated in the pathogenesis of a vast array of disease processes including some neurological disorders. Method. Ten patients with Guillain-Barre syndrome (GBS) and 10 age and sex-matched controls were included in this study. The erythrocyte glutathione (GSH), superoxide dismutase (SOD) and malondialdehyde (MDA) levels, as well as plasma antioxidant vitamins C and E and serum glutathione-S-transferase (GST) levels were estimated spectrophotometrically. Results. The plasma vitamin E and the serum total glutathione-S-transferase levels were markedly increased in both pre- and post-treated cases of GBS when compared to controls. The erythrocyte glutathione and malondialdehyde levels were significantly reduced in GBS cases when compared to normals. However, plasma vitamin C and erythrocyte superoxide dismutase were not altered when compared to controls. Conclusion. Free radical toxicity may have an influence in patients suffering from GBS.

Original languageEnglish
Pages (from-to)205-209
Number of pages5
JournalClinica Chimica Acta
Issue number2
Publication statusPublished - 16-08-2004
Externally publishedYes


All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Kumar, K. T., Chandrika, A., Sumanth, K. N., Sireesha, P., Rao, S., & Rao, A. (2004). Free radical toxicity and antioxidants in Guillain-Barre syndrome, a preliminary study. Clinica Chimica Acta, 346(2), 205-209.