Free radical toxicity and antioxidants in Parkinson's disease

K. Sudha, Anjali V. Rao, S. Rao, A. Rao

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Erythrocyte lipid peroxidation, oxidative hemolysis, erythrocyte antioxidant enzymes, viz. superoxide dismutase, glutathione reductase, glutathione peroxidase, catalase and plasma antioxidants, viz. vitamin A, vitamin E, vitamin C and ceruloplasmin have been determined by spectrophotometric methods in 15 patients with Parkinson's disease (PD) and in 50 controls. Lipid peroxidation, oxidative hemolysis and plasma ceruloplasmin were significantly higher in PD patients as compared to normals. Erythrocyte antioxidants in PD patients were not significantly different from the controls. However, plasma vitamin C in PD patients was significantly lower than the controls. It is concluded that these patients are under oxidative stress which points to a possible involvement of free radicals in PD.

Original languageEnglish
Pages (from-to)60-62
Number of pages3
JournalNeurology India
Volume51
Issue number1
Publication statusPublished - 01-03-2003

Fingerprint

Free Radicals
Parkinson Disease
Antioxidants
Ceruloplasmin
Erythrocytes
Hemolysis
Lipid Peroxidation
Ascorbic Acid
Glutathione Reductase
Glutathione Peroxidase
Catalase
Superoxide Dismutase
Oxidative Stress
Enzymes

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Sudha, K., Rao, A. V., Rao, S., & Rao, A. (2003). Free radical toxicity and antioxidants in Parkinson's disease. Neurology India, 51(1), 60-62.
Sudha, K. ; Rao, Anjali V. ; Rao, S. ; Rao, A. / Free radical toxicity and antioxidants in Parkinson's disease. In: Neurology India. 2003 ; Vol. 51, No. 1. pp. 60-62.
@article{acca50e27d8c45d5accecfffb75f028c,
title = "Free radical toxicity and antioxidants in Parkinson's disease",
abstract = "Erythrocyte lipid peroxidation, oxidative hemolysis, erythrocyte antioxidant enzymes, viz. superoxide dismutase, glutathione reductase, glutathione peroxidase, catalase and plasma antioxidants, viz. vitamin A, vitamin E, vitamin C and ceruloplasmin have been determined by spectrophotometric methods in 15 patients with Parkinson's disease (PD) and in 50 controls. Lipid peroxidation, oxidative hemolysis and plasma ceruloplasmin were significantly higher in PD patients as compared to normals. Erythrocyte antioxidants in PD patients were not significantly different from the controls. However, plasma vitamin C in PD patients was significantly lower than the controls. It is concluded that these patients are under oxidative stress which points to a possible involvement of free radicals in PD.",
author = "K. Sudha and Rao, {Anjali V.} and S. Rao and A. Rao",
year = "2003",
month = "3",
day = "1",
language = "English",
volume = "51",
pages = "60--62",
journal = "Neurology India",
issn = "0028-3886",
publisher = "Medknow Publications and Media Pvt. Ltd",
number = "1",

}

Sudha, K, Rao, AV, Rao, S & Rao, A 2003, 'Free radical toxicity and antioxidants in Parkinson's disease', Neurology India, vol. 51, no. 1, pp. 60-62.

Free radical toxicity and antioxidants in Parkinson's disease. / Sudha, K.; Rao, Anjali V.; Rao, S.; Rao, A.

In: Neurology India, Vol. 51, No. 1, 01.03.2003, p. 60-62.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Free radical toxicity and antioxidants in Parkinson's disease

AU - Sudha, K.

AU - Rao, Anjali V.

AU - Rao, S.

AU - Rao, A.

PY - 2003/3/1

Y1 - 2003/3/1

N2 - Erythrocyte lipid peroxidation, oxidative hemolysis, erythrocyte antioxidant enzymes, viz. superoxide dismutase, glutathione reductase, glutathione peroxidase, catalase and plasma antioxidants, viz. vitamin A, vitamin E, vitamin C and ceruloplasmin have been determined by spectrophotometric methods in 15 patients with Parkinson's disease (PD) and in 50 controls. Lipid peroxidation, oxidative hemolysis and plasma ceruloplasmin were significantly higher in PD patients as compared to normals. Erythrocyte antioxidants in PD patients were not significantly different from the controls. However, plasma vitamin C in PD patients was significantly lower than the controls. It is concluded that these patients are under oxidative stress which points to a possible involvement of free radicals in PD.

AB - Erythrocyte lipid peroxidation, oxidative hemolysis, erythrocyte antioxidant enzymes, viz. superoxide dismutase, glutathione reductase, glutathione peroxidase, catalase and plasma antioxidants, viz. vitamin A, vitamin E, vitamin C and ceruloplasmin have been determined by spectrophotometric methods in 15 patients with Parkinson's disease (PD) and in 50 controls. Lipid peroxidation, oxidative hemolysis and plasma ceruloplasmin were significantly higher in PD patients as compared to normals. Erythrocyte antioxidants in PD patients were not significantly different from the controls. However, plasma vitamin C in PD patients was significantly lower than the controls. It is concluded that these patients are under oxidative stress which points to a possible involvement of free radicals in PD.

UR - http://www.scopus.com/inward/record.url?scp=0041803095&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0041803095&partnerID=8YFLogxK

M3 - Article

VL - 51

SP - 60

EP - 62

JO - Neurology India

JF - Neurology India

SN - 0028-3886

IS - 1

ER -