Free radicals and antioxidant therapy in clinical practice: To be or not to be?

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Abstract

Free radicals and antioxidant therapy haw attracted a great deal of attention in recent years. Current research reveals the potential applications of antioxidants in prevention or control of disease. However, controversy still exists due to lack of well controlled clinical trials and definitive conclusion on efficacy/safety. This article highlights the debatable issues related to this. Based on the available literature and clinician's experience, recommendation on antioxidant usage is mentioned at the end. There is a need to assimilate the known available informalion with extensive research to establish a positive role of antioxidant therapy In clinical practice and to use an evidence-based approach for summarizing data, drawing conclusions and making recommendations about antioxidant usage and efficacy. A substantial gap still exists between the claims and the efficacy/safety in this area of research.
Original languageEnglish
Pages (from-to)173-174
Number of pages2
JournalJournal of the College of Physicians and Surgeons--Pakistan : JCPSP
Volume17
Issue number3
Publication statusPublished - 2007

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Free Radicals
Antioxidants
Research
Therapeutics
Safety
Controlled Clinical Trials

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@article{1809b55f5bba47cc846e0f1630dcb92e,
title = "Free radicals and antioxidant therapy in clinical practice: To be or not to be?",
abstract = "Free radicals and antioxidant therapy haw attracted a great deal of attention in recent years. Current research reveals the potential applications of antioxidants in prevention or control of disease. However, controversy still exists due to lack of well controlled clinical trials and definitive conclusion on efficacy/safety. This article highlights the debatable issues related to this. Based on the available literature and clinician's experience, recommendation on antioxidant usage is mentioned at the end. There is a need to assimilate the known available informalion with extensive research to establish a positive role of antioxidant therapy In clinical practice and to use an evidence-based approach for summarizing data, drawing conclusions and making recommendations about antioxidant usage and efficacy. A substantial gap still exists between the claims and the efficacy/safety in this area of research.",
author = "S. Carnelio and S.A. Khan and G.S. Rodrigues",
note = "Cited By :3 Export Date: 10 November 2017 CODEN: JSPJE Correspondence Address: Rodrigues, G. S.; Department of Surgery, 157, KMC Quarters, Madhav Nagar, Manipal - 576 104. Karnataka, India; email: rodricksgaby@yahoo.co.in Chemicals/CAS: Antioxidants; Free Radicals References: Howes, R.M., The free radical fantasy: Panoply of paradoxes (2006) Ann NY Acad Sci, 1067, pp. 22-26; Valko, M., Leibfritz, D., Moncol, J., Cronin, M.T., Mazur, M., Telser, J., Free radicals and antioxidants in normal physiological functions and human disease (2006) Int J Biochem Cell Biol, 39, pp. 44-84; Thompson, H.J., DNA oxidation products, antioxidant status and cancer presentation (2004) J Nutr, 134, pp. 3186S-3187S; Conklin, K., Cancer chemotherapy and antioxidants: An overview (2006) Free Radicals: The Pros and Cons of Antioxidants, , 29th Oct; Borek, C., Antioxidants and radiation therapy (2004) J Nutr, 134, pp. 3207S-3209S; Meyers, D.G., Maloley, P.A., Weeks, D., Safety of antioxidant vitamins (1996) Arch Intern Med, 156, pp. 925-935; Skibsted, L.H., Dragsted, L.O., Dyerberg, J., Hansen, H.S., Kiens, B., Ovesen, L.F., Antioxidants and health (2006) Ugeskr Laeger, 168, pp. 2787-2789; Devasagayam, T., Tilak, J.C., Boloor, K.K., Sane, K., Ghaskadbi, S., Lele, R.D., Free radicals and antioxidants in human health: Current status and future prospects (2004) J Assoc Pbysicians India, 52, pp. 794-804; Sharda, B., Free radicals: Emerging challenge in environmental health research in childhood and neonatal disorders (2006) Int J Environ Res Public Health, 3, pp. 286-291; Marlin-Du Pan, R.C., Sakkas, D., Is antioxidant therapy a promising strategy to improve human reproduction? Are antioxidants useful in the treatment of male infertility? (1998) Hum Reprod, 13, pp. 2984-2985",
year = "2007",
language = "English",
volume = "17",
pages = "173--174",
journal = "Journal of the College of Physicians and Surgeons--Pakistan : JCPSP",
issn = "1022-386X",
publisher = "College of Physicians and Surgeons Pakistan",
number = "3",

}

TY - JOUR

T1 - Free radicals and antioxidant therapy in clinical practice: To be or not to be?

AU - Carnelio, S.

AU - Khan, S.A.

AU - Rodrigues, G.S.

N1 - Cited By :3 Export Date: 10 November 2017 CODEN: JSPJE Correspondence Address: Rodrigues, G. S.; Department of Surgery, 157, KMC Quarters, Madhav Nagar, Manipal - 576 104. Karnataka, India; email: rodricksgaby@yahoo.co.in Chemicals/CAS: Antioxidants; Free Radicals References: Howes, R.M., The free radical fantasy: Panoply of paradoxes (2006) Ann NY Acad Sci, 1067, pp. 22-26; Valko, M., Leibfritz, D., Moncol, J., Cronin, M.T., Mazur, M., Telser, J., Free radicals and antioxidants in normal physiological functions and human disease (2006) Int J Biochem Cell Biol, 39, pp. 44-84; Thompson, H.J., DNA oxidation products, antioxidant status and cancer presentation (2004) J Nutr, 134, pp. 3186S-3187S; Conklin, K., Cancer chemotherapy and antioxidants: An overview (2006) Free Radicals: The Pros and Cons of Antioxidants, , 29th Oct; Borek, C., Antioxidants and radiation therapy (2004) J Nutr, 134, pp. 3207S-3209S; Meyers, D.G., Maloley, P.A., Weeks, D., Safety of antioxidant vitamins (1996) Arch Intern Med, 156, pp. 925-935; Skibsted, L.H., Dragsted, L.O., Dyerberg, J., Hansen, H.S., Kiens, B., Ovesen, L.F., Antioxidants and health (2006) Ugeskr Laeger, 168, pp. 2787-2789; Devasagayam, T., Tilak, J.C., Boloor, K.K., Sane, K., Ghaskadbi, S., Lele, R.D., Free radicals and antioxidants in human health: Current status and future prospects (2004) J Assoc Pbysicians India, 52, pp. 794-804; Sharda, B., Free radicals: Emerging challenge in environmental health research in childhood and neonatal disorders (2006) Int J Environ Res Public Health, 3, pp. 286-291; Marlin-Du Pan, R.C., Sakkas, D., Is antioxidant therapy a promising strategy to improve human reproduction? Are antioxidants useful in the treatment of male infertility? (1998) Hum Reprod, 13, pp. 2984-2985

PY - 2007

Y1 - 2007

N2 - Free radicals and antioxidant therapy haw attracted a great deal of attention in recent years. Current research reveals the potential applications of antioxidants in prevention or control of disease. However, controversy still exists due to lack of well controlled clinical trials and definitive conclusion on efficacy/safety. This article highlights the debatable issues related to this. Based on the available literature and clinician's experience, recommendation on antioxidant usage is mentioned at the end. There is a need to assimilate the known available informalion with extensive research to establish a positive role of antioxidant therapy In clinical practice and to use an evidence-based approach for summarizing data, drawing conclusions and making recommendations about antioxidant usage and efficacy. A substantial gap still exists between the claims and the efficacy/safety in this area of research.

AB - Free radicals and antioxidant therapy haw attracted a great deal of attention in recent years. Current research reveals the potential applications of antioxidants in prevention or control of disease. However, controversy still exists due to lack of well controlled clinical trials and definitive conclusion on efficacy/safety. This article highlights the debatable issues related to this. Based on the available literature and clinician's experience, recommendation on antioxidant usage is mentioned at the end. There is a need to assimilate the known available informalion with extensive research to establish a positive role of antioxidant therapy In clinical practice and to use an evidence-based approach for summarizing data, drawing conclusions and making recommendations about antioxidant usage and efficacy. A substantial gap still exists between the claims and the efficacy/safety in this area of research.

M3 - Article

VL - 17

SP - 173

EP - 174

JO - Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

JF - Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

SN - 1022-386X

IS - 3

ER -