Function and regulation of melanoma-stromal fibroblast interactions

When seeds meet soil

Gang Li, Kapaettu Satyamoorthy, Friedegund Meier, Carola Berking, Thomas Bogenrieder, Meenhard Herlyn

    Research output: Contribution to journalReview article

    122 Citations (Scopus)

    Abstract

    Melanoma development and progression not only involve genetic and epigenetic changes that take place within the melanocytic cells, hut also involve processes that are determined collectively by contextual factors including intercellular adhesions and communications. In this review, we focus on melanoma-stromal fibroblast cross-talk by direct cell-cell contact and by growth factors/cytokines/chemokines interacting with their respective receptors. The interactions between melanoma cells and stromal fibroblasts create a context that promotes tumor growth, migration/invasion, and angiogenesis. An understanding of this process and developing new experimental and screening models are of great importance for the development of effective therapeutical strategies to treat melanoma.

    Original languageEnglish
    Pages (from-to)3162-3171
    Number of pages10
    JournalOncogene
    Volume22
    Issue number20
    DOIs
    Publication statusPublished - 19-05-2003

    Fingerprint

    Melanoma
    Seeds
    Soil
    Fibroblasts
    Stromal Cells
    Chemokines
    Epigenomics
    Intercellular Signaling Peptides and Proteins
    Theoretical Models
    Cytokines
    Growth
    Neoplasms

    All Science Journal Classification (ASJC) codes

    • Molecular Biology
    • Genetics
    • Cancer Research

    Cite this

    Li, Gang ; Satyamoorthy, Kapaettu ; Meier, Friedegund ; Berking, Carola ; Bogenrieder, Thomas ; Herlyn, Meenhard. / Function and regulation of melanoma-stromal fibroblast interactions : When seeds meet soil. In: Oncogene. 2003 ; Vol. 22, No. 20. pp. 3162-3171.
    @article{0462ac24c624497bb4bdbfbbfecfd328,
    title = "Function and regulation of melanoma-stromal fibroblast interactions: When seeds meet soil",
    abstract = "Melanoma development and progression not only involve genetic and epigenetic changes that take place within the melanocytic cells, hut also involve processes that are determined collectively by contextual factors including intercellular adhesions and communications. In this review, we focus on melanoma-stromal fibroblast cross-talk by direct cell-cell contact and by growth factors/cytokines/chemokines interacting with their respective receptors. The interactions between melanoma cells and stromal fibroblasts create a context that promotes tumor growth, migration/invasion, and angiogenesis. An understanding of this process and developing new experimental and screening models are of great importance for the development of effective therapeutical strategies to treat melanoma.",
    author = "Gang Li and Kapaettu Satyamoorthy and Friedegund Meier and Carola Berking and Thomas Bogenrieder and Meenhard Herlyn",
    year = "2003",
    month = "5",
    day = "19",
    doi = "10.1038/sj.onc.1206455",
    language = "English",
    volume = "22",
    pages = "3162--3171",
    journal = "Oncogene",
    issn = "0950-9232",
    publisher = "Nature Publishing Group",
    number = "20",

    }

    Function and regulation of melanoma-stromal fibroblast interactions : When seeds meet soil. / Li, Gang; Satyamoorthy, Kapaettu; Meier, Friedegund; Berking, Carola; Bogenrieder, Thomas; Herlyn, Meenhard.

    In: Oncogene, Vol. 22, No. 20, 19.05.2003, p. 3162-3171.

    Research output: Contribution to journalReview article

    TY - JOUR

    T1 - Function and regulation of melanoma-stromal fibroblast interactions

    T2 - When seeds meet soil

    AU - Li, Gang

    AU - Satyamoorthy, Kapaettu

    AU - Meier, Friedegund

    AU - Berking, Carola

    AU - Bogenrieder, Thomas

    AU - Herlyn, Meenhard

    PY - 2003/5/19

    Y1 - 2003/5/19

    N2 - Melanoma development and progression not only involve genetic and epigenetic changes that take place within the melanocytic cells, hut also involve processes that are determined collectively by contextual factors including intercellular adhesions and communications. In this review, we focus on melanoma-stromal fibroblast cross-talk by direct cell-cell contact and by growth factors/cytokines/chemokines interacting with their respective receptors. The interactions between melanoma cells and stromal fibroblasts create a context that promotes tumor growth, migration/invasion, and angiogenesis. An understanding of this process and developing new experimental and screening models are of great importance for the development of effective therapeutical strategies to treat melanoma.

    AB - Melanoma development and progression not only involve genetic and epigenetic changes that take place within the melanocytic cells, hut also involve processes that are determined collectively by contextual factors including intercellular adhesions and communications. In this review, we focus on melanoma-stromal fibroblast cross-talk by direct cell-cell contact and by growth factors/cytokines/chemokines interacting with their respective receptors. The interactions between melanoma cells and stromal fibroblasts create a context that promotes tumor growth, migration/invasion, and angiogenesis. An understanding of this process and developing new experimental and screening models are of great importance for the development of effective therapeutical strategies to treat melanoma.

    UR - http://www.scopus.com/inward/record.url?scp=0038456148&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=0038456148&partnerID=8YFLogxK

    U2 - 10.1038/sj.onc.1206455

    DO - 10.1038/sj.onc.1206455

    M3 - Review article

    VL - 22

    SP - 3162

    EP - 3171

    JO - Oncogene

    JF - Oncogene

    SN - 0950-9232

    IS - 20

    ER -