Function and regulation of melanoma-stromal fibroblast interactions: When seeds meet soil

Gang Li, Kapaettu Satyamoorthy, Friedegund Meier, Carola Berking, Thomas Bogenrieder, Meenhard Herlyn

    Research output: Contribution to journalReview article

    126 Citations (Scopus)

    Abstract

    Melanoma development and progression not only involve genetic and epigenetic changes that take place within the melanocytic cells, hut also involve processes that are determined collectively by contextual factors including intercellular adhesions and communications. In this review, we focus on melanoma-stromal fibroblast cross-talk by direct cell-cell contact and by growth factors/cytokines/chemokines interacting with their respective receptors. The interactions between melanoma cells and stromal fibroblasts create a context that promotes tumor growth, migration/invasion, and angiogenesis. An understanding of this process and developing new experimental and screening models are of great importance for the development of effective therapeutical strategies to treat melanoma.

    Original languageEnglish
    Pages (from-to)3162-3171
    Number of pages10
    JournalOncogene
    Volume22
    Issue number20
    DOIs
    Publication statusPublished - 19-05-2003

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    All Science Journal Classification (ASJC) codes

    • Molecular Biology
    • Genetics
    • Cancer Research

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