Fusion of spatial gray level dependency and fractal texture features for the characterization of thyroid lesions

U. Raghavendra, U. Rajendra Acharya, Anjan Gudigar, Jen Hong Tan, Hamido Fujita, Yuki Hagiwara, Filippo Molinari, Pailin Kongmebhol, Kwan Hoong Ng

Research output: Contribution to journalArticle

16 Citations (Scopus)


Thyroid is a small gland situated at the anterior side of the neck and one of the largest glands of the endocrine system. The abrupt cell growth or malignancy in the thyroid gland may cause thyroid cancer. Ultrasound images distinctly represent benign and malignant lesions, but accuracy may be poor due to subjective interpretation. Computer Aided Diagnosis (CAD) can minimize the errors created due to subjective interpretation and assists to make fast accurate diagnosis. In this work, fusion of Spatial Gray Level Dependence Features (SGLDF) and fractal textures are used to decipher the intrinsic structure of benign and malignant thyroid lesions. These features are subjected to graph based Marginal Fisher Analysis (MFA) to reduce the number of features. The reduced features are subjected to various ranking methods and classifiers. We have achieved an average accuracy, sensitivity and specificity of 97.52%, 90.32% and 98.57% respectively using Support Vector Machine (SVM) classifier. The achieved maximum Area Under Curve (AUC) is 0.9445. Finally, Thyroid Clinical Risk Index (TCRI) a single number is developed using two MFA features to discriminate the two classes. This prototype system is ready to be tested with huge diverse database.

Original languageEnglish
Pages (from-to)110-120
Number of pages11
Publication statusPublished - 01-05-2017


All Science Journal Classification (ASJC) codes

  • Acoustics and Ultrasonics

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